Výsledky vyhledávání - "Hélène Jacquemin-Sablon"

Unr defines a novel class of nucleoplasmic reticulum involved in mRNA translation

Autor: Pierre Costet, Pierre Dubus, Oréda Boussadia, Nathalie Dugot-Senant, Lucile Miquerol, Frédéric Saltel, Harald Wodrich, Alban Giese, Hélène Jacquemin-Sablon, Zakaria Ezzoukhry, Habiba Elatmani, Lamia Azzi

Publikováno v: Journal of Cell Science
Journal of Cell Science, 2017, 130 (10), pp.1796-1808. ⟨10.1242/jcs.198697⟩
Journal of Cell Science, Company of Biologists, 2017, 130 (10), pp.1796-1808. ⟨10.1242/jcs.198697⟩

International audience; Unr (officially known as CSDE1) is a cytoplasmic RNA-binding protein with roles in the regulation of mRNA stability and translation. In this study, we identified a novel function for Unr, which acts as a positive regulator of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e9d4fdc649a8b72fe1fdf890c04625
http://hdl.handle.net/20.500.12278/111802

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Unr, a cytoplasmic RNA-binding protein with cold-shock domains, is involved in control of apoptosis in ES and HuH7 cells

Autor: D Montaudon, P Lagarde, A Jacquemin-Sablon, S Huet, Hélène Jacquemin-Sablon, J Markovits, V Dormoy-Raclet, Y Malato

Publikováno v: Oncogene. 26:2595-2605

Unr (upstream of N-ras) is a cytoplasmic RNA-binding protein involved in the regulation of messenger RNA stability and internal initiation of translation. We have used Unr-deficient murine embryonic stem (ES) cells to analyse Unr role in cell prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe49cc18a4b6025f573991adf5341c1
https://doi.org/10.1038/sj.onc.1210068

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A Mechanism for Translationally Coupled mRNA Turnover

Autor: Christophe Grosset, Ann-Bin Shyu, Nianhua Xu, Hélène Jacquemin-Sablon, Chyi-Ying A. Chen, Nahum Sonenberg

Publikováno v: Cell. 103(1):29-40

mRNA turnover mediated by the major protein-coding-region determinant of instability (mCRD) of the c-fos proto-oncogene transcript illustrates a functional interplay between mRNA turnover and translation. We show that the function of mCRD depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79140d96298ba1ced2f57e4161a2ef1a

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RNA binding specificity of Unr, a protein with five cold shock domains

Autor: Gérard Triqueneaux, Hélène Jacquemin-Sablon, Marion Velten, François Dautry, Pascale Franzon

Publikováno v: Nucleic Acids Research. 27:1926-1934

The human unr gene encodes an 85 kDa protein which contains five cold shock domains (CSD). The capacity of Unr to interact in vitro with RNA and its intracellular localization suggest that Unr could be involved in some aspect of cytoplasmic mRNA meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4327dbb770f7ac00c79e234f813fb4bb
https://doi.org/10.1093/nar/27.8.1926

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A functional screening identifies five micrornas controlling glypican-3: role of mir-1271 down-regulation in hepatocellular carcinoma

Autor: Paulette Bioulac-Sage, Benoît Laloo, Francis Sagliocco, Chantal Combe, Christophe Grosset, Sandra Jalvy, Hélène Jacquemin-Sablon, Vincent Pitard, Yannick Ladeiro, Marion Maurel, Jessica Zucman-Rossi, Laetitia Vachet

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2013, 57 (1), pp.195-204. ⟨10.1002/hep.25994⟩
Hepatology, 2013, 57 (1), pp.195-204. ⟨10.1002/hep.25994⟩

International audience; Hepatocellular carcinoma (HCC) is the major primary liver cancer. Glypican-3 (GPC3), one of the most abnormally expressed genes in HCC, participates in liver carcinogenesis. Based on data showing that GPC3 expression is posttr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24901353343e658fa4b28a30d6bfa17b
https://www.hal.inserm.fr/inserm-02437938/document

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Genomic cloning of human thioredoxin-encoding gene: mapping of the transcription start point and analysis of the promoter

Autor: Mourad Kaghad, Daniel Caput, Emmanuelle E. Wollman, Didier Fradelizi, Hélène Jacquemin-Sablon, Françoise Dessarps

Publikováno v: Gene. 140:273-278

Thioredoxin (TR) is a small ubiquitous dithiol-reductase enzyme first identified in bacteria and plants. In recent years, this protein has been recognized as playing an important role in the growth control of eukaryotic cells, especially in lymphocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30559497ab486f9df0bf124088dcbb39
https://doi.org/10.1016/0378-1119(94)90557-6

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The RNA-Binding Protein Unr Prevents Mouse Embryonic Stem Cells Differentiation Toward the Primitive Endoderm Lineage

Autor: Pierre Dubus, François Dautry, Virginie Dormoy-Raclet, Claire Chazaud, Habiba Elatmani, Hélène Jacquemin-Sablon

Publikováno v: STEM CELLS
STEM CELLS, AlphaMed Press, 2011, 29 (10), pp.1504-1516. ⟨10.1002/stem.712⟩
STEM CELLS, 2011, 29 (10), pp.1504-1516. ⟨10.1002/stem.712⟩

The maintenance of embryonic stem cells (ESCs) pluripotency depends on key transcription factors, chromatin remodeling proteins, and microRNAs. The roles of RNA-binding proteins are however poorly understood. We report that the cytoplasmic RNA-bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeccb3e19850471d14652185c365647
https://hal.archives-ouvertes.fr/hal-01923180

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P3‐335: Upstream of N‐ras (UNR) is involved in translational control of ADAM10 protein expression

Autor: Sonja Zilow, Ann-Katrin Ludwig, Claudia Prinzen, Christian Haass, Falk Fahrenholz, Dominik Büll, Sven Lammich, Hélène Jacquemin-Sablon

Publikováno v: Alzheimer's & Dementia. 4

Background: The amyloid beta peptide (A ) is derived by proteolytic processing of the amyloid precursor protein (APP) by the beta-secretase BACE1 and gamma-secretase. In contrast to this amyloidogenic processing, APP is predominantly cleaved by the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da8c8b92821bf4f4451a8872e7325039
https://doi.org/10.1016/j.jalz.2008.05.1904

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Regulation of Unr expression by 5'- and 3'-untranslated regions of its mRNA through modulation of stability and IRES mediated translation

Autor: Judith Markovits, Virginie Dormoy-Raclet, Alain Jacquemin-Sablon, Hélène Jacquemin-Sablon

Publikováno v: RNA biology. 2(3)

Unr (upstream of N-ras) is a cytoplasmic RNA-binding protein that can act as a regulator of mRNA stability and IRES-mediated translation. Unr, a member of the cold-shock domain (CSD) protein super-family, is ubiquitously expressed, with variable abun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861a5f449ba07966f77bb92e28502aa6
https://pubmed.ncbi.nlm.nih.gov/17114922

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Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus

Autor: Anne-Catherine Prats, François Dautry, Michael Niepmann, Laurent Créancier, Hélène Jacquemin-Sablon, Oréda Boussadia

Publikováno v: Journal of virology. 77(6)

Translation of picornavirus RNAs is mediated by internal ribosomal entry site (IRES) elements and requires both standard eukaryotic translation initiation factors (eIFs) and IRES-specific cellular trans -acting factors (ITAFs). Unr, a cytoplasmic RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807588aed5e07539e5dcdbdffe67e87d
https://pubmed.ncbi.nlm.nih.gov/12610110

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