Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hélène Gouget"'
Autor:
Caroline Passaes, Delphine Desjardins, Anaïs Chapel, Valérie Monceaux, Julien Lemaitre, Adeline Mélard, Federico Perdomo-Celis, Cyril Planchais, Maël Gourvès, Nastasia Dimant, Annie David, Nathalie Dereuddre-Bosquet, Aurélie Barrail-Tran, Hélène Gouget, Céline Guillaume, Francis Relouzat, Olivier Lambotte, Jérémie Guedj, Michaela Müller-Trutwin, Hugo Mouquet, Christine Rouzioux, Véronique Avettand-Fenoël, Roger Le Grand, Asier Sáez-Cirión
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract HIV remission can be achieved in some people, called post-treatment HIV controllers, after antiretroviral treatment discontinuation. Treatment initiation close to the time of infection was suggested to favor post-treatment control, but the c
Externí odkaz:
https://doaj.org/article/661b86229b42429d8450453e606a9ab0
Autor:
Thibaut Gelé, Hélène Gouget, Nathalie Dereuddre-Bosquet, Valérie Furlan, Roger Le Grand, Olivier Lambotte, Delphine Desjardins, Aurélie Barrail-Tran
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2282 (2022)
The development of animal models undergoing long-term antiretroviral treatment (ART) makes it possible to understand a number of immunological, virological, and pharmacological issues, key factors in the management of HIV infection. We aimed to pharm
Externí odkaz:
https://doaj.org/article/c22b7677f8bc4894bae9d1f72940c31a
Autor:
Asier Saez-Cirion, Caroline Passaes, Delphine Desjardins, Anais Chapel, Valérie Monceaux, Julien Lemaitre, Adeline Melard, Veronique Avettand-Fenoel, Federico Perdomo-Celis, Michaela Müller-Trutwin, Hugo Mouquet, Cyril Planchais, Annie David, Roger Le Grand, Nastasia Dimant, Nathalie Bosquet, Aurélie Barrail-Tran, Hélène Gouget, Céline Guillaume, Francis Relouzat, Olivier Lambotte, Jeremie Guedj, Christine Rouzioux
Post-treatment HIV controllers (PTCs) offer evidence that HIV remission can be achieved in some people after antiretroviral treatment (ART) discontinuation. However, the circumstances and mechanisms leading to PTC remain unclear. We evaluated the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::470e372369fcc8b6c2f8fadd7d2bcf6f
https://doi.org/10.21203/rs.3.rs-2777698/v1
https://doi.org/10.21203/rs.3.rs-2777698/v1
Autor:
Laura Labarthe, Thibaut Gelé, Hélène Gouget, Mariam-Sarah Benzemrane, Pauline Le Calvez, Nicolas Legrand, Olivier Lambotte, Roger Le Grand, Christine Bourgeois, Aurélie Barrail-Tran
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:1094-1101
Background Studies of antiretroviral drug (ARV) tissue distribution in preclinical models, such as mice, are key to understanding viral persistence. Objectives To determine the plasma and tissue pharmacokinetics and tissue distributions of tenofovir,
Autor:
Jacques Gasnault, Pierre-Hadrien Becker, Lionelle Nkam, Antoine Cheret, Anne-Marie Taburet, Aurélie Barrail-Tran, Valérie Furlan, Pilartxo Catalan, Cécile Goujard, Thibaut Gelé, Hélène Gouget, Coralie Pallier, Alicia Castro Gordon
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2021, 76 (12), pp.3280-3285. ⟨10.1093/jac/dkab334⟩
Journal of Antimicrobial Chemotherapy, 2021, 76 (12), pp.3280-3285. ⟨10.1093/jac/dkab334⟩
Objectives The penetration of antiretroviral drugs into deep compartments, such as the CNS, is a crucial component of strategies towards an HIV cure. This study aimed to determine CSF concentrations of bictegravir, emtricitabine and tenofovir in pati
Autor:
Clément M. Haeck, Peter Boyd, Nastasia Dimant, Aurélie Barrail-Tran, Hélène Gouget, Roger Le Grand, Delphine Desjardins, R. Karl Malcolm
Publikováno v:
Haeck, C M, Boyd, P, Dimant, N, Barrail-Tran, A, Gouget, H, Le Grand, R, Desjardins, D & Malcolm, R K 2023, ' Preclinical development and pharmacokinetic assessment in macaques of a multipurpose long-acting injectable suspension containing medroxyprogesterone acetate for contraception and rilpivirine for HIV prevention ', Journal of Drug Delivery Science and Technology, vol. 85, 104590 . https://doi.org/10.1016/j.jddst.2023.104590
Depot injections comprising aqueous drug suspensions are widely marketed for long-acting administration of contraceptive progestins and antipsychotics. In recent years, there has been considerable interest in developing similar long-acting injectable
Autor:
Hélène Gouget, Anne-Marie Taburet, Aurélie Barrail-Tran, Thibaut Gelé, Pierre-Hadrien Becker, Olivier Lambotte, Valérie Furlan
Publikováno v:
Antimicrob Agents Chemother
This study aimed to characterize in vitro dolutegravir (DTG) and bictegravir (BIC) binding. They had a preferential binding to human serum albumin (HSA) with two classes of albumin sites. Human alpha-1-acid glycoprotein (HAAG) binding of DTG and BIC
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 181:113057
A sensitive and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for 14 antiretroviral drugs and 2 boosters in human plasma. Plasma (100 μL) was precipitated with a solu