S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases

Autor: Fanny Duguet, Céline Ortega-Ferreira, Benjamin Fould, Hélène Darville, Sylvie Berger, Agnès Chomel, Grégory Leclerc, Kai Kisand, Liis Haljasmägi, Adrian C. Hayday, Emiko Desvaux, Emmanuel Nony, Philippe Moingeon, Frédéric De Ceuninck

Publikováno v: Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100093- (2021)

Increased interferon-α (IFN-α) production is a critical component in the pathophysiology of systemic lupus erythematosus (SLE) and other rheumatic autoimmune diseases. Herein, we report the characterization of S95021, a fully human IgG1 anti–IFN�

Externí odkaz: https://doaj.org/article/5dc19eec2b97490ca0d3a3cdf5238fde

Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome

Autor: Hélène Darville, Aurélie Poulet, Frédérique Rodet-Amsellem, Laure Chatrousse, Julie Pernelle, Claire Boissart, Delphine Héron, Caroline Nava, Anselme Perrier, Margot Jarrige, Francis Cogé, Mark J. Millan, Thomas Bourgeron, Marc Peschanski, Richard Delorme, Alexandra Benchoua

Publikováno v: EBioMedicine, Vol 9, Iss C, Pp 293-305 (2016)

Autism spectrum disorders affect millions of individuals worldwide, but their heterogeneity complicates therapeutic intervention that is essentially symptomatic. A versatile yet relevant model to rationally screen among hundreds of therapeutic option

Externí odkaz: https://doaj.org/article/565244f27fd642b8bb6fb30450b1ca3f

Phase I results of S49076 plus gefitinib in patients with EGFR TKI-resistant non-small cell lung cancer harbouring MET/AXL dysregulation

Autor: Miguel Angel Molina-Vila, Eric Gandossi, Hélène Darville, Santiago Viteri, R.A. Soo, Wan-Teck Lim, Isabelle Sudey, Giuseppe Curigliano, Gee-Chen Chang, Valérie Cattan, Veronika Smutna, Keunchil Park

Publikováno v: Lung cancer (Amsterdam, Netherlands). 155

Background MET and AXL dysregulation is reported as a bypass mechanism driving tumour progression in non-small cell lung cancer (NSCLC) with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). This non-comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0fb31e912be42e0439eb94cd0a8c5b
https://pubmed.ncbi.nlm.nih.gov/33798902

S.12.02 A human pluripotent stem cell-derived neuronal model for characterisation of pathways regulating the autism and schizophrenia-related gene SHANK-3

Autor: Millan Mark, Hélène Darville, Aurélie Poulet, J. Pernelle, Thomas Bourgeron, Richard Delorme, F. Coge, Alexandra Benchoua, Marc Peschanski

Publikováno v: European Neuropsychopharmacology. 25:S127

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aacf919c824ef3c6be32a1b4e9a490df
https://doi.org/10.1016/s0924-977x(15)30062-6

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Autor: Sophie Landron, Audrey Chabrat, Alain Dupront, Rodolphe Billiras, Francois Feron, Clotilde Mannoury la Cour, Francis Cogé, David Piwnica, Emmanuel Nivet, Esther Schenker, Hélène Darville, Amélie Pontisso-Mahout, Emmanuelle Lacassagne

Publikováno v: Stem Cells International
Stem Cells International, 2019, 2019, pp.eCollection 2019. ⟨10.1155/2019/2945435⟩
Stem Cells International, Hindawi Publishing Corporation, 2019, 2019, pp.eCollection 2019. ⟨10.1155/2019/2945435⟩
Stem Cells International, Vol 2019 (2019)

The discovery of novel drugs for neurodegenerative diseases has been a real challenge over the last decades. The development of patient- and/or disease-specificin vitromodels represents a powerful strategy for the development and validation of lead c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9f84bd723dfc451a150640099319f3