Výsledky vyhledávání - "Hélène Couthon"

Akademický článek

Synthesis of ether lipids: natural compounds and analogues

Autor: Marco Antônio G. B. Gomes, Alicia Bauduin, Chloé Le Roux, Romain Fouinneteau, Wilfried Berthe, Mathieu Berchel, Hélène Couthon, Paul-Alain Jaffrès

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1299-1369 (2023)

Ether lipids are compounds present in many living organisms including humans that feature an ether bond linkage at the sn-1 position of the glycerol. This class of lipids features singular structural roles and biological functions. Alkyl ether lipids

Externí odkaz: https://doaj.org/article/06e6abc3844546eab02e1fb8d946abb2

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Akademický článek

Development of a High-Performance Thin-Layer Chromatography Method for the Quantification of Alkyl Glycerolipids and Alkenyl Glycerolipids from Shark and Chimera Oils and Tissues

Autor: Marion Papin, Cyrille Guimaraes, Benoit Pierre-Aue, Delphine Fontaine, Jeoffrey Pardessus, Hélène Couthon, Gaëlle Fromont, Karine Mahéo, Aurélie Chantôme, Christophe Vandier, Michelle Pinault

Publikováno v: Marine Drugs, Vol 20, Iss 4, p 270 (2022)

Ether lipids are composed of alkyl lipids with an ether bond at the sn-1 position of a glycerol backbone and alkenyl lipids, which possess a vinyl ether bond at the sn-1 position of the glycerol. These ether glycerolipids are present either as polar

Externí odkaz: https://doaj.org/article/29f58eb25dad4ae198c61c4bb4f13dd2

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Akademický článek

Phosphonic acid: preparation and applications

Autor: Charlotte M. Sevrain, Mathieu Berchel, Hélène Couthon, Paul-Alain Jaffrès

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2186-2213 (2017)

The phosphonic acid functional group, which is characterized by a phosphorus atom bonded to three oxygen atoms (two hydroxy groups and one P=O double bond) and one carbon atom, is employed for many applications due to its structural analogy with the

Externí odkaz: https://doaj.org/article/acc647b0188648229ec367bf6089abab

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Akademický článek

Singular Interaction between an Antimetastatic Agent and the Lipid Bilayer: The Ohmline Case

Autor: Fernando E. Herrera, Charlotte M. Sevrain, Paul-Alain Jaffrès, Hélène Couthon, Axelle Grélard, Erick J. Dufourc, Aurélie Chantôme, Marie Potier-Cartereau, Christophe Vandier, Ana M. Bouchet

Publikováno v: ACS Omega, Vol 2, Iss 10, Pp 6361-6370 (2017)

Externí odkaz: https://doaj.org/article/0e21c0203d09460484e7d383c8bc90e7

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Akademický článek

Atherton–Todd reaction: mechanism, scope and applications

Autor: Stéphanie S. Le Corre, Mathieu Berchel, Hélène Couthon-Gourvès, Jean-Pierre Haelters, Paul-Alain Jaffrès

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1166-1196 (2014)

Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of carbon tetrachloride. These reaction conditions were subsequently modified with the a

Externí odkaz: https://doaj.org/article/b8d7281fe58d484ab04496faf48daadd

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Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect

Autor: Côme Pasqualin, Véronique Maupoil, Alicia Bauduin, Maxime Guéguinou, Bei Li Zhang, Hélène Couthon, Aurélie Chantôme, Christophe Vandier, Charlotte M. Sevrain, Karine Mahéo, Delphine Fontaine, Paul-Alain Jaffrès

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2021, 19 (12), pp.2753-2766. ⟨10.1039/D1OB00021G⟩

International audience; The modulation of SK3 ion channels can be efficiently and selectively achieved by using the amphiphilic compound Ohmline (a glyco-glycero-ether-lipid). We report herein a series of Ohmline analogues featuring the replacement o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7fcc71aa2e93b9ec878c3bd41d15d1
https://hal.univ-brest.fr/hal-03187829

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Development of pyrene-based fluorescent ether lipid as inhibitor of SK3 ion channels

Autor: Aurélie Chantôme, Marion Papin, Hélène Couthon, Alicia Bauduin, Paul-Alain Jaffrès, Jose Requejo-Isidro, Christophe Vandier, Laure Deschamps

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩
European Journal of Medicinal Chemistry, 2021, 209, pp.112894. ⟨10.1016/j.ejmech.2020.112894⟩

We report the synthesis of three bioactive pyrene-based fluorescent analogues of Ohmline which is the most efficient and selective inhibitor of SK3 ion channel. The interaction of these Ohmline-pyrene (OP1-3) with liposomes of different composition r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be511f0c54c1a46cc00df01dc154d59
https://hal.univ-brest.fr/hal-02997273

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M(H2O)(PO3C10H6OH)·(H2O)0.5 (M = Co, Mn, Zn, Cu): a new series of layered metallophosphonate compoundsobtained from 6-hydroxy-2-naphthylphosphonic acid

Autor: Fabien Veillon, Hélène Couthon, Guillaume Rogez, Félicien Beaubras, Charlotte Jestin, Jean-Michel Rueff, Jean-François Lohier, Olivier Perez, Vincent Caignaert, Julien Cardin, Paul-Alain Jaffrès

Publikováno v: Dalton Transactions
Dalton Transactions, Royal Society of Chemistry, 2020, 49 (12), pp.3877-3891. ⟨10.1039/C9DT03947C⟩
Dalton Transactions, Royal Society of Chemistry, 2020, 49 (12), pp.3877-3891. ⟨10.1039/c9dt03947c⟩
Dalton Transactions, 2020, 49 (12), pp.3877-3891. ⟨10.1039/C9DT03947C⟩

International audience; Four new metallophosphonates M(H2O)(PO3C10H6OH)·(H2O)0.5 (M = Mn, Co, Cu, Zn) were obtained as single crystal and polycrystalline powders by hydrothermal synthesis from the precursors 6-hydroxy-2-naphthylphosphonic acid and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd68928af8a883388af588caa1b2501
https://hal.archives-ouvertes.fr/hal-02413390/file/Beaubras_Dalton_2020_HAL.pdf

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