ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer

Autor: Ankit Pandey, Hélène Cousin, Brett Horr, Dominique Alfandari

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Introduction: Cranial neural crest (CNC) cells are induced at the border of the neural plate by a combination of FGF, Wnt, and BMP4 signaling. CNC then migrate ventrally and invade ventral structures where they contribute to craniofacial development.

Externí odkaz: https://doaj.org/article/f573c0c713a143b79de1810a8f146eaa

Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation

Autor: Ida Signe Bohse Larsen, Adnan Halim, Jill B. Graham, Johan C. Sunryd, Dominque Alfandari, Ketan Mathavan, Daniel N. Hebert, Emma Weir, Hélène Cousin, Henrik Clausen

Publikováno v: Molecular Biology of the Cell
Graham, J B, Sunryd, J C, Mathavan, K, Weir, E, Larsen, I S B, Halim, A, Clausen, H, Cousin, H, Alfandari, D & Hebert, D N 2020, ' Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation ', Molecular Biology of the Cell, vol. 31, no. 3, pp. 167-183 . https://doi.org/10.1091/mbc.E19-07-0408

Protein glycosylation plays essential roles in protein structure, stability, and activity such as cell adhesion. The cadherin superfamily of adhesion molecules carry O-linked mannose glycans at conserved sites and it was recently demonstrated that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3b870848eea9554fa6de1f97dfbb1d
http://europepmc.org/articles/PMC7001481

Cranial Neural Crest Explants

Autor: Hélène Cousin, Dominique Alfandari

Publikováno v: Cold Spring Harbor protocols. 2018(3)

The cranial neural crest (CNC) explant assay was originally designed to assess the basic requirements for CNC migration in vitro. This protocol describes the key parameters of CNC explants in Xenopus laevis, with a focus on how to extirpate CNC cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5ff7af18ba1686ff704eb523e6a6dd
https://pubmed.ncbi.nlm.nih.gov/29321283

Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a

Autor: Hannah S. Szydlo, Hélène Cousin, Dominique Alfandari, Vikram Khedgikar, Ketan Mathavan, Genevieve Abbruzzese

Publikováno v: eLife, Vol 6 (2017)
eLife

Adam13/33 is a cell surface metalloprotease critical for cranial neural crest (CNC) cell migration. It can cleave multiple substrates including itself, fibronectin, ephrinB, cadherin-11, pcdh8 and pcdh8l (this work). Cleavage of cadherin-11 produces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca674984c381a7ebf3f0eaaae0f6991
https://elifesciences.org/articles/26898

Zmym4 is required for early cranial gene expression and craniofacial cartilage formation

Autor: Karyn Jourdeuil, Karen M. Neilson, Helene Cousin, Andre L. P. Tavares, Himani D. Majumdar, Dominique Alfandari, Sally A. Moody

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Introduction: The Six1 transcription factor plays important roles in the development of cranial sensory organs, and point mutations underlie craniofacial birth defects. Because Six1’s transcriptional activity can be modulated by interacting protein

Externí odkaz: https://doaj.org/article/104114d54fb74f9685f062e1854349bc