Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

Autor: Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge

Publikováno v: PLoS Genetics, Vol 13, Iss 3, p e1006593 (2017)

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway ove

Externí odkaz: https://doaj.org/article/0da1b265333b4d3d89cda4194d8f09d6

A New Manganese Superoxide Dismutase Mimetic Improves Oxaliplatin-Induced Neuropathy and Global Tolerance in Mice

Autor: Caroline Prieux-Klotz, Henri Chédotal, Martha Zoumpoulaki, Sandrine Chouzenoux, Charlotte Chêne, Alvaro Lopez-Sanchez, Marine Thomas, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Hélène C. Bertrand, Carole Nicco, Romain Coriat

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12938
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (21), pp.12938. ⟨10.3390/ijms232112938⟩

International audience; Reactive oxygen species (ROS) are produced by every aerobic cell during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Superoxide Dismutases (SOD) are anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579fd4ac5d7aad8981386aa092271a1c
https://doi.org/10.3390/ijms232112938