Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Hélène Bénédetti"'
Autor:
Bojan Žunar, Taiga Ito, Christine Mosrin, Yoshiyuki Sugahara, Hélène Bénédetti, Régis Guégan, Béatrice Vallée
Publikováno v:
Biomaterials Research, Vol 26, Iss 1, Pp 1-15 (2022)
Abstract Background Engineered living materials (ELMs) combine living cells with non-living scaffolds to obtain life-like characteristics, such as biosensing, growth, and self-repair. Some ELMs can be 3D-printed and are called bioinks, and their scaf
Externí odkaz:
https://doaj.org/article/dd034ee33e4f41388ac7845cccdecd00
Autor:
Hélène Bénédetti, Béatrice Vallée
Publikováno v:
Cells, Vol 12, Iss 12, p 1649 (2023)
LIM kinases (LIMKs), LIMK1 and LIMK2, are atypical kinases, as they are the only two members of the LIM kinase family harbouring two LIM domains at their N-terminus and a kinase domain at their C-terminus [...]
Externí odkaz:
https://doaj.org/article/f5cfaaa57a4b4d5b85f68a61ae405fdf
Autor:
Elodie Villalonga, Christine Mosrin, Thierry Normand, Caroline Girardin, Amandine Serrano, Bojan Žunar, Michel Doudeau, Fabienne Godin, Hélène Bénédetti, Béatrice Vallée
Publikováno v:
Cells, Vol 12, Iss 5, p 805 (2023)
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. They play a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtub
Externí odkaz:
https://doaj.org/article/b3b06cb558dc48d3866e0df980021655
Publikováno v:
Cells, Vol 11, Iss 13, p 2090 (2022)
LIM Kinases are important actors in the regulation of cytoskeleton dynamics by controlling microtubule and actin filament turnover. The signaling pathways involving LIM kinases for actin filament remodeling are well established. They are downstream e
Externí odkaz:
https://doaj.org/article/b28c384611024df3a87676a8f1a8312d
Autor:
Frédéric Buron, Nuno Rodrigues, Thibault Saurat, Marie Aude Hiebel, Stéphane Bourg, Pascal Bonnet, Reine Nehmé, Philippe Morin, Nathalie Percina, Justine Corret, Béatrice Vallée, Remy le Guevel, Marie-Lise Jourdan, Hélène Bénédetti, Sylvain Routier
Publikováno v:
Molecules, Vol 26, Iss 17, p 5349 (2021)
This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-d]pyrimidines. The series synthesized offers a chemical diversity in C-7 whereas C
Externí odkaz:
https://doaj.org/article/6a0143f187a1484fb74923056d30d307
Autor:
Mohammed Bergoug, Michel Doudeau, Fabienne Godin, Christine Mosrin, Béatrice Vallée, Hélène Bénédetti
Publikováno v:
Cells, Vol 9, Iss 11, p 2365 (2020)
Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 (NF1). Over the last three decades, studies of neurofibromin structure,
Externí odkaz:
https://doaj.org/article/e87b3ee4bbdf4b3883a5c5c84fc2ec10
Autor:
Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, Marie-Ludivine de Tauzia, Hélène Bénédetti
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47283 (2012)
BACKGROUND: Ras GTPases mediate numerous biological processes through their ability to cycle between an inactive GDP-bound form and an active GTP-bound form. Guanine nucleotide exchange factors (GEFs) favor the formation of the active Ras-GTP, wherea
Externí odkaz:
https://doaj.org/article/9f09953b68e94f839a86b19f8bb87796
Autor:
Mohammed Bergoug, Christine Mosrin, Fabienne Godin, Michel Doudeau, Iva Sosic, Marcin Suskiewicz, Béatrice Vallée, Hélène Bénédetti
Neurofibromin (Nf1) is a large multidomain protein encoded by the tumour-suppressor gene NF1. NF1 is mutated in a frequently occurring genetic disease, neurofibromatosis type I, and in various cancers. The best described function of Nf1 is its Ras-GT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed97e11006e0a18e17e2c012db60dba1
https://doi.org/10.1101/2021.12.09.471973
https://doi.org/10.1101/2021.12.09.471973
Autor:
Pascal Bonnet, Philippe Morin, Marie-Lise Jourdan, Reine Nehmé, Hélène Bénédetti, Marie Aude Hiebel, Sylvain Routier, Rémy Le Guével, Béatrice Vallée, Justine Corret, Nathalie Percina, Frédéric Buron, Stéphane Bourg, Thibault Saurat, Nuno Rodrigues
Publikováno v:
Molecules, Vol 26, Iss 5349, p 5349 (2021)
Molecules
Molecules, MDPI, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Volume 26
Issue 17
Molecules
Molecules, MDPI, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩
Volume 26
Issue 17
International audience; This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-d]pyrimidines. The series synthesized offers a chemical di
Autor:
Sylviane Marouillat, Rose-Anne Thépault, Frédéric Laumonnier, Annick Toutain, Patrick Vourc'h, H. Cubéros, Béatrice Vallée, Hélène Bénédetti, Martine Raynaud, Christian R. Andres, Frédérique Bonnet-Brilhault, Julie Tastet
Publikováno v:
Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩
Neuroscience, Elsevier-International Brain Research Organization, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩
International audience; LIMK2 is involved in neuronal functions by regulating actin dynamics. Different isoforms of LIMK2 are described in databanks. LIMK2a and LIMK2b are the most characterized. A few pieces of evidence suggest that LIMK2 isoforms m