Výsledky vyhledávání - "Hélène, Bachelard"

Akademický článek

Picomolar Sensitivity Analysis of Multiple Bradykinin-Related Peptides in the Blood Plasma of Patients With Hereditary Angioedema in Remission: A Pilot Study

Autor: François Marceau, Georges-Etienne Rivard, Jacques Hébert, Julie Gauthier, Hélène Bachelard, Tanja Gangnus, Bjoern B. Burckhardt

Publikováno v: Frontiers in Allergy, Vol 3 (2022)

BackgroundHereditary angioedema (HAE) is a rare autosomal dominant disease; the most well understood forms concern the haplodeficiency of C1 esterase inhibitor (C1INH) and a gain of function mutation of factor XII (FXII). The acute forms of these con

Externí odkaz: https://doaj.org/article/d6d6984eeddc4df18e7c64ca05824963

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Akademický článek

Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitors

Autor: François Marceau, Hélène Bachelard, Georges-Étienne Rivard, Jacques Hébert

Publikováno v: BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)

Abstract Objective We recently investigated the pathways of immunoreactive bradykinin (iBK) formation in fresh blood of normal volunteers and of patients with hereditary angioedema due to C1-esterase inhibitor deficiency (HAE-1/-2). Herein, we adapte

Externí odkaz: https://doaj.org/article/953d4ec9425f4130bcbfe9fb970da964

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Akademický článek

Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants

Autor: François Marceau, Georges E. Rivard, Julie M. Gauthier, Karen E. Binkley, Arnaud Bonnefoy, Isabelle Boccon-Gibod, Laurence Bouillet, Matthieu Picard, Ghislain Levesque, Hannah Laure Elfassy, Hélène Bachelard, Jacques Hébert, Konrad Bork

Publikováno v: Frontiers in Medicine, Vol 7 (2020)

Bradykinin (BK)-mediated angioedema (AE) states are rare acquired or hereditary conditions involving localized edema of the subcutaneous and submucosal tissues. Citrated plasma from healthy volunteers or patients with hereditary angioedema (HAE) with

Externí odkaz: https://doaj.org/article/8214c6f93a4949ccbb088b8b53b02298

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Akademický článek

A Robust Bioassay of the Human Bradykinin B2 Receptor That Extends Molecular and Cellular Studies: The Isolated Umbilical Vein

Autor: François Marceau, Hélène Bachelard

Publikováno v: Pharmaceuticals, Vol 14, Iss 3, p 177 (2021)

Bradykinin (BK) has various physiological and pathological roles. Medicinal chemistry efforts targeted toward the widely expressed BK B2 receptor (B2R), a G-protein-coupled receptor, were primarily aimed at developing antagonists. The only B2R antago

Externí odkaz: https://doaj.org/article/c8da2586de2541ba8f75ca8f5b284ff9

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Akademický článek

In Vitro Modeling of Bradykinin-Mediated Angioedema States

Autor: François Marceau, Hélène Bachelard, Xavier Charest-Morin, Jacques Hébert, Georges E. Rivard

Publikováno v: Pharmaceuticals, Vol 13, Iss 9, p 201 (2020)

Kinins (peptides related to bradykinin, BK) are formed from circulating substrates, the kininogens, by the action of two proteases, the kallikreins. The only clinical application of a BK receptor ligand, the B2 receptor antagonist icatibant, is the t

Externí odkaz: https://doaj.org/article/de7c23917d4747fbac219d2cbe676707

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Akademický článek

D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases

Autor: Hélène Bachelard, Xavier Charest-Morin, François Marceau

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

We previously reported hypotensive and vasodilator effects from C-terminally extended bradykinin (BK) sequences that behave as B2 receptor (B2R) agonists activated by vascular or plasma peptidases. D-Arg0-BK-Arg-Arg (r-BK-RR) is a novel prodrug pepti

Externí odkaz: https://doaj.org/article/ec948c02ce484ffcbdfaa4461294ca16

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Akademický článek

Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B2 receptor and peptidase resistance in rats

Autor: Xavier Charest-Morin, Hélène Bachelard, Melissa Jean, Francois Marceau

Publikováno v: PeerJ, Vol 5, p e2911 (2017)

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmat

Externí odkaz: https://doaj.org/article/f06d2050ad614c879558085f9e1d9f52

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