Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hélèna L. Denis"'
Autor:
Marie Rieux, Melanie Alpaugh, Shireen Salem, Alberto Siddu, Martine Saint-Pierre, Hélèna L. Denis, Heike Rohweder, Frank Herrmann, Chantal Bazenet, Steve Lacroix, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106289- (2023)
Externí odkaz:
https://doaj.org/article/20374c4117494cd5af4a06381e01cf57
Autor:
Marie Rieux, Melanie Alpaugh, Shireen Salem, Alberto Siddu, Martine Saint-Pierre, Hélèna L. Denis, Heike Rohweder, Frank Herrmann, Chantal Bazenet, Steve Lacroix, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106091- (2023)
In a previous study, we have shown that parabiotic coupling of a knock-in mouse model (zQ175) of Huntington's disease (HD) to wild-type (WT) littermates resulted in a worsening of the normal phenotype as seen by detection of mutant huntingtin protein
Externí odkaz:
https://doaj.org/article/e49ceef186c14eb781f5cade28f1336a
Autor:
Jérôme Lamontagne-Proulx, Isabelle St-Amour, Richard Labib, Jérémie Pilon, Hélèna L. Denis, Nathalie Cloutier, Florence Roux-Dalvai, Antony T. Vincent, Sarah L. Mason, Caroline Williams-Gray, Anne-Claire Duchez, Arnaud Droit, Steve Lacroix, Nicolas Dupré, Mélanie Langlois, Sylvain Chouinard, Michel Panisset, Roger A. Barker, Eric Boilard, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 163-175 (2019)
The production of extracellular vesicles (EV) is a ubiquitous feature of eukaryotic cells but pathological events can affect their formation and constituents. We sought to characterize the nature, profile and protein signature of EV in the plasma of
Externí odkaz:
https://doaj.org/article/8d8cf4f9837744e3b7e12b8b5fafeecf
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
The types of treatments and interventions being developed for chronic neurodegenerative disorders have expanded considerably in recent years. In addition to the variety of targets being pursued, strategies have moved from symptom management to more d
Externí odkaz:
https://doaj.org/article/26878de6e20e4203ada4ee7773602c66
Autor:
Melanie Alpaugh, Maria Masnata, Aurelie de Rus Jacquet, Eva Lepinay, Hélèna L. Denis, Martine Saint-Pierre, Peter Davies, Emmanuel Planel, Francesca Cicchetti
Publikováno v:
Molecular Therapy. 30:1500-1522
Huntington's disease is classically described as a neurodegenerative disorder of monogenic aetiology. The disease is characterized by an abnormal polyglutamine expansion in the huntingtin gene, which drives the toxicity of the mutated form of the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48053239374828bd5c12e84cc44497e4
https://doi.org/10.1016/j.ymthe.2022.01.020
https://doi.org/10.1016/j.ymthe.2022.01.020
Publikováno v:
Mol Psychiatry
Neurodegenerative disorders emerge from the failure of intricate cellular mechanisms, which ultimately lead to the loss of vulnerable neuronal populations. Research conducted across several laboratories has now provided compelling evidence that patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fc52cb77567ada37e1584fc3cfc78a
https://doi.org/10.1038/s41380-020-00999-7
https://doi.org/10.1038/s41380-020-00999-7
Publikováno v:
Molecular psychiatry. 27(1)
If theories postulating that pathological proteins associated with neurodegenerative disorders behave similarly to prions were initially viewed with reluctance, it is now well-accepted that this occurs in several disease contexts. Notably, it has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882953f9da99c3eb162176564308a500
https://pubmed.ncbi.nlm.nih.gov/34711942
https://pubmed.ncbi.nlm.nih.gov/34711942
Autor:
Andrew S. Weyrich, Eric Boilard, Jérôme Lamontagne-Proulx, Isabelle St-Amour, Hélèna L Denis, Marie-Ève Tremblay, Sarah L Mason, Nathalie Cloutier, Peter V Gould, Matthew T. Rondina, Antony T. Vincent, Roger A. Barker, Sylvain Chouinard, Jesse W. Rowley, Francesca Cicchetti
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
Huntington’s disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the production o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a34dbd2658ff98b7b73cf2d4a6a798
https://doi.org/10.1136/jnnp-2018-318854
https://doi.org/10.1136/jnnp-2018-318854
Autor:
Isabelle St-Amour, Eric Boilard, Andreas Weiss, Hélèna L Denis, Roger A. Barker, Jérôme Lamontagne-Proulx, Sylvain Chouinard, Francesca Cicchetti, Sarah L Mason
Publikováno v:
Journal of Neurology. 265:2704-2712
The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222885c8791f5e603f26ff237fa66073
https://doi.org/10.1007/s00415-018-9022-5
https://doi.org/10.1007/s00415-018-9022-5
Publikováno v:
Molecular Psychiatry. 24:364-377
There is compelling evidence that the pathophysiology of many neurodegenerative diseases includes dysregulation of the immune system, with some elements that precede disease onset. However, if these alterations are prominent, why have clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f351fe841948e136ea31343ca5e0ed
https://doi.org/10.1038/s41380-018-0021-9
https://doi.org/10.1038/s41380-018-0021-9