Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Héctor de Lucio"'
Autor:
Juan Carlos García-Soriano, Héctor de Lucio, Daniel Elvira-Blázquez, Mercedes Alcón-Calderón, Natalia Sanz del Olmo, Pedro A. Sánchez-Murcia, Paula Ortega, Francisco Javier de la Mata, Antonio Jiménez-Ruiz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Species of Leishmania and Trypanosoma genera are the causative agents of relevant parasitic diseases. Survival inside their hosts requires the existence of a potent antioxidant enzymatic machinery. Four iron superoxide dismutases have been described
Externí odkaz:
https://doaj.org/article/8b837ee27de94e09b9a3c10679f946f3
Autor:
Alejandro Revuelto, Isabel López-Martín, Héctor de Lucio, Juan Carlos García-Soriano, Nicola Zanda, Sonia de Castro, Federico Gago, Antonio Jiménez-Ruiz, Sonsoles Velázquez, María-José Camarasa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 689 (2021)
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Externí odkaz:
https://doaj.org/article/ae16e1932b9142b884536d0bb5ad011f
Autor:
Héctor de Lucio, Alejandro Revuelto, Alejandra A. Carriles, Sonia de Castro, Sonia García-González, Juan Carlos García-Soriano, Mercedes Alcón-Calderón, Pedro A. Sánchez-Murcia, Juan A. Hermoso, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez
Publikováno v:
European journal of medicinal chemistry. 244
N-methylation of the triazole moiety present in our recently described triazole-phenyl-thiazole dimerization disruptors of Leishmania infantum trypanothione disulfide reductase (LiTryR) led to a new class of potent in- hibitors that target different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef646e59d43fd7ad91c8810435c36267
https://pubmed.ncbi.nlm.nih.gov/36332553
https://pubmed.ncbi.nlm.nih.gov/36332553
Autor:
Andreina Henriquez-Figuereo, Mercedes Alcon, Esther Moreno, Carmen Sanmartín, Socorro Espuelas, Héctor de Lucio, Antonio Jiménez-Ruiz, Daniel Plano
Publikováno v:
Bioorganic Chemistry. :106624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cddccedba215c34d84f56dd0d1a69824
https://doi.org/10.1016/j.bioorg.2023.106624
https://doi.org/10.1016/j.bioorg.2023.106624
Autor:
Mercedes Alcón-Calderón, Héctor de Lucio, Juan Carlos García-Soriano, Alejandro Revuelto, Sonia de Castro, Celia López-Gutiérrez, Ana San-Félix, Ernesto Quesada, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypa- nothione disulfide reductase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb3a98ac776176e5a689cd192aca99
http://hdl.handle.net/10261/279364
http://hdl.handle.net/10261/279364
Autor:
Nicola Zanda, Sonia de Castro, Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Federico Gago, Alejandro Revuelto, María-José Camarasa, Isabel López-Martín, Sonsoles Velázquez
Publikováno v:
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
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Volume 14
Issue 7
Pharmaceuticals, Vol 14, Iss 689, p 689 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously obtained proof of concept th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a9ce634fa455ae08cf88bb33627385
Autor:
Ana Bravo, Paula M. Petrone, Héctor de Lucio, Alvaro Cortes Cabrera, Antonio Jiménez-Ruiz, Federico Gago, Pedro A. Sánchez-Murcia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Lithium ion, commonly used as the carbonate salt in the treatment of bipolar disorders, has been identified as an inhibitor of several kinases, including Glycogen Synthase Kinase-3β, for almost 20 years. However, both the exact mechanism of enzymati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1f6ce768bdc390d96d5d4d45d58aef
https://doi.org/10.1111/cbdd.13487
https://doi.org/10.1111/cbdd.13487
Autor:
Juan Carlos García-Soriano, Antonio Jiménez-Ruiz, Héctor de Lucio, Sonsoles Velázquez, Federico Gago, Alejandro Revuelto, María-José Camarasa, Pedro A. Sánchez-Murcia
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Medicinal Chemistry
instname
Journal of Medicinal Chemistry
Inhibition of Leishmania infantum trypanothione disulfide reductase (LiTryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of concept was firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca5784a0763c514320a850ea5fdb2fc
http://hdl.handle.net/10261/252819
http://hdl.handle.net/10261/252819
Autor:
Miguel A. Toro, Antonio Jiménez-Ruiz, Federico Gago, Sonsoles Velázquez, Héctor de Lucio, María-José Camarasa
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Br J Pharmacol
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Br J Pharmacol
Background and Purpose: Peptide P4 was described as a dimerization disruptor of trypanothione reductase (TryR), a homodimeric enzyme essential for survival of trypanosomatids. Determination of the true inhibitory constant (K) for P4 was not achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089842e6cecff6e9fe99157ffe5c9e6d
http://hdl.handle.net/10261/224929
http://hdl.handle.net/10261/224929
Autor:
Ramón Alajarín, Juan J. Vaquero, Juan Carlos García-Soriano, Federico Gago, Héctor de Lucio, Javier García-Marín, Miguel A. Toro, Antonio Jiménez-Ruiz, Patricia Sánchez-Alonso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Fifteen pyridazino-pyrrolo-quinoxalinium salts were synthesized and tested for their antiprotozoal activity against Leishmania infantum amastigotes. Eleven of them turned out to be leishmanicidal, with EC values in the nanomolar range, and displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82360f923704ae2a98e5746ed1068d9
https://doi.org/10.1016/j.ejmech.2021.113915
https://doi.org/10.1016/j.ejmech.2021.113915