Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Héctor González-Álvarez"'
Autor:
Mark F. Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W. Kimani, Ahmed Mamai, Chiara Krausser, Héctor González-Álvarez, Smriti Srivastava, Mohammed Mohammed, Laurent Hoffer, Manuel Chan, Jamie Avrumutsoae, Alice Shi Ming Li, Taraneh Hajian, Sarah Tucker, Stuart Green, Magdalena Szewczyk, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Suzanne Ackloo, Peter Loppnau, Yanjun Li, Almagul Seitova, Taira Kiyota, Jue George Wang, Gilbert G. Privé, Douglas A. Kuntz, Bhashant Patel, Vaibhavi Rathod, Anand Vala, Bhimsen Rout, Ahmed Aman, Gennady Poda, David Uehling, Jailall Ramnauth, Levon Halabelian, Richard Marcellus, Rima Al-awar, Masoud Vedadi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Proteolysis-targeting chimeras (PROTACs) have been explored for the degradation of drug targets for more than two decades. However, only a handful of E3 ligase substrate receptors have been efficiently used. Downregulation and mutation of th
Externí odkaz:
https://doaj.org/article/3472b510aaa44f048ba5f7afe215f30a
Autor:
Héctor González-Álvarez, Astrid Bravo-Jiménez, Matilda Martínez-Arellanes, Gabriela Odette Gamboa-Osorio, Edwin Chávez-Gutiérrez, Lino A. González-Hernández, Karina Gallardo-Ignacio, Osvaldo J. Quintana-Romero, Armando Ariza-Castolo, Christian Guerra-Araiza, Laura Martino-Roaro, Dulce María Meneses-Ruiz, Rodolfo Pinto-Almazán, Marco A. Loza-Mejía
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 914 (2021)
Metabolic syndrome (MetS) is a complex disease that affects almost a quarter of the world’s adult population. In MetS, diabetes, obesity, hyperglycemia, high cholesterol, and high blood pressure are the most common disorders. Polypharmacy is the mo
Externí odkaz:
https://doaj.org/article/db78b5d3a7034990bd754ae975ddea9b
Autor:
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi
Publikováno v:
Journal of Medicinal Chemistry. 66:5041-5060
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d2380cfc1eda17d3f8edf2cae4eb67
https://doi.org/10.1021/acs.jmedchem.2c02132
https://doi.org/10.1021/acs.jmedchem.2c02132
Autor:
Rachel Harding, M.K. Mann, Ahmed Aman, Carlos Zepeda-Velázquez, Brian J. Wilson, Taira Kiyota, Cheryl H. Arrowsmith, Peter Loppnau, Rima Al-awar, Matthieu Schapira, Héctor González-Álvarez, Yanjun Li, Aiping Dong
Publikováno v:
Journal of Medicinal Chemistry. 64:15017-15036
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f2b58e16e289efc68af8b3a1671546
https://doi.org/10.1021/acs.jmedchem.1c00889
https://doi.org/10.1021/acs.jmedchem.1c00889
Autor:
Armando Ariza-Castolo, Edwin Chávez-Gutiérrez, Marco A. Loza-Mejía, Astrid Bravo-Jiménez, Dulce María Meneses-Ruiz, Christian Guerra-Araiza, Rodolfo Pinto-Almazán, Héctor González-Álvarez, Matilda Martínez-Arellanes, Laura Martino-Roaro, Lino A. González-Hernández, Gabriela Odette Gamboa-Osorio, Karina Gallardo-Ignacio, Osvaldo J. Quintana-Romero
Publikováno v:
Pharmaceuticals
Volume 14
Issue 9
Pharmaceuticals, Vol 14, Iss 914, p 914 (2021)
Volume 14
Issue 9
Pharmaceuticals, Vol 14, Iss 914, p 914 (2021)
Metabolic syndrome (MetS) is a complex disease that affects almost a quarter of the world’s adult population. In MetS, diabetes, obesity, hyperglycemia, high cholesterol, and high blood pressure are the most common disorders. Polypharmacy is the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbe113db4010d9a18b1e67c3ee96c7e
Autor:
Mandeep K. Mann, Carlos A. Zepeda-Velázquez, Héctor González-Álvarez, Aiping Dong, Taira Kiyota, Ahmed M. Aman, Peter Loppnau, Yanjun Li, Brian Wilson, Cheryl H. Arrowsmith, Rima Al-Awar, Rachel J. Harding, Matthieu Schapira
Publikováno v:
Journal of Medicinal Chemistry. 65:889-889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b8a021a6e69d4aee6483892d7535d7a
https://doi.org/10.1021/acs.jmedchem.1c02118
https://doi.org/10.1021/acs.jmedchem.1c02118