Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Héctor García Martín"'
Autor:
Garrett W. Birkel, Amit Ghosh, Vinay S. Kumar, Daniel Weaver, David Ando, Tyler W. H. Backman, Adam P. Arkin, Jay D. Keasling, Héctor García Martín
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Modeling of microbial metabolism is a topic of growing importance in biotechnology. Mathematical modeling helps provide a mechanistic understanding for the studied process, separating the main drivers from the circumstantial ones,
Externí odkaz:
https://doaj.org/article/97efd12eba8047718e7bf3427294a120
Autor:
Christopher M. Shymansky, George Wang, Edward E. K. Baidoo, Jennifer Gin, Amanda Reider Apel, Aindrila Mukhopadhyay, Héctor García Martín, Jay D. Keasling
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 5 (2017)
13C metabolic flux analysis (13C MFA) is an important systems biology technique that has been used to investigate microbial metabolism for decades. The heterotrimer Snf1 kinase complex plays a key role in the preference Saccharomyces cerevisiae exhib
Externí odkaz:
https://doaj.org/article/652dce928a9d4899a61b7c5150920876
Autor:
Garrett W. Birkel, Amit Ghosh, Vinay S. Kumar, Daniel Weaver, David Ando, Tyler W. H. Backman, Adam P. Arkin, Jay D. Keasling, Héctor García Martín
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-2 (2017)
Externí odkaz:
https://doaj.org/article/51aa0b07f1c347cca58e56e7344f22d8
Publikováno v:
Metabolites, Vol 8, Iss 1, p 3 (2018)
Determination of internal metabolic fluxes is crucial for fundamental and applied biology because they map how carbon and electrons flow through metabolism to enable cell function. 13 C Metabolic Flux Analysis ( 13 C MFA) and Two-Scale 13 C Metabolic
Externí odkaz:
https://doaj.org/article/09b648dfe0254dafbf1f20e9a7516c89
Autor:
Héctor García Martín, Vinay Satish Kumar, Daniel Weaver, Amit Ghosh, Victor Chubukov, Aindrila Mukhopadhyay, Adam Arkin, Jay D Keasling
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 9, p e1004363 (2015)
Current limitations in quantitatively predicting biological behavior hinder our efforts to engineer biological systems to produce biofuels and other desired chemicals. Here, we present a new method for calculating metabolic fluxes, key targets in met
Externí odkaz:
https://doaj.org/article/2d21dfd63e974fb58d198764fe40d5fe
Autor:
Amit Ghosh, Jerome Nilmeier, Daniel Weaver, Paul D Adams, Jay D Keasling, Aindrila Mukhopadhyay, Christopher J Petzold, Héctor García Martín
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003827 (2014)
The study of intracellular metabolic fluxes and inter-species metabolite exchange for microbial communities is of crucial importance to understand and predict their behaviour. The most authoritative method of measuring intracellular fluxes, 13C Metab
Externí odkaz:
https://doaj.org/article/daf55b5700b140c5ba608372832823fb
Autor:
Jason Fontana, David Sparkman-Yager, Ian Faulkner, Ryan Cardiff, Cholpisit Kiattisewee, Aria Walls, Tommy G. Primo, Patrick C. Kinnunen, Hector Garcia Martin, Jesse G. Zalatan, James M. Carothers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Engineering metabolism to efficiently produce chemicals from multi-step pathways requires optimizing multi-gene expression programs to achieve enzyme balance. CRISPR-Cas transcriptional control systems are emerging as important tools for pro
Externí odkaz:
https://doaj.org/article/5e3002d716ec47ceb8dca2261e3ce3bb
Autor:
David, Ando, Héctor, García Martín
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1859
Synthetic biology is a rapidly developing field that pursues the application of engineering principles and development approaches to biological engineering. Synthetic biology is poised to change the way biology is practiced, and has important practic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03c38666aeb77d8c93d37eef76137350
https://pubmed.ncbi.nlm.nih.gov/30421239
https://pubmed.ncbi.nlm.nih.gov/30421239
Autor:
Tyler W H Backman, Christina Schenk, Tijana Radivojevic, David Ando, Jahnavi Singh, Jeffrey J Czajka, Zak Costello, Jay D Keasling, Yinjie Tang, Elena Akhmatskaya, Hector Garcia Martin
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011111 (2023)
Metabolic fluxes, the number of metabolites traversing each biochemical reaction in a cell per unit time, are crucial for assessing and understanding cell function. 13C Metabolic Flux Analysis (13C MFA) is considered to be the gold standard for measu
Externí odkaz:
https://doaj.org/article/23460991878e4f2daf19048745ca008c
Autor:
María J. Hernáiz, Alvaro Cortes Cabrera, Héctor García-Martín, J. Vicent Sinisterra, José I. García, María Pérez-Sánchez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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A noticeably increase in activity, keeping total regioselectivity was found in the synthetic behaviour of Escherichia coli β-galactosidase in glycerol-based solvents using a 1:7 molar ratio of donor (pNP-β-Gal): acceptor (GlcNAc). Yields of up to 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2b01af6580fbfb5ec8c8fa5028d05d
https://doi.org/10.1016/j.tet.2011.08.009
https://doi.org/10.1016/j.tet.2011.08.009