Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Héctor G Jasper"'
Autor:
Andrew Dauber, María T Muñoz‐Calvo, Vicente Barrios, Horacio M Domené, Soren Kloverpris, Clara Serra‐Juhé, Vardhini Desikan, Jesús Pozo, Radhika Muzumdar, Gabriel Á Martos‐Moreno, Federico Hawkins, Héctor G Jasper, Cheryl A Conover, Jan Frystyk, Shoshana Yakar, Vivian Hwa, Julie A Chowen, Claus Oxvig, Ron G Rosenfeld, Luis A Pérez‐Jurado, Jesús Argente
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 4, Pp 363-374 (2016)
Abstract Mutations in multiple genes of the growth hormone/IGF‐I axis have been identified in syndromes marked by growth failure. However, no pathogenic human mutations have been reported in the six high‐affinity IGF‐binding proteins (IGFBPs) o
Externí odkaz:
https://doaj.org/article/224828b64cec4bdd98548afe1c5d47d5
Autor:
Estefanía Landi, Liliana Karabatas, Tomás Rodríguez Gomez, Lucía Salatino, Paula Scaglia, Laura Ramírez, Ana Keselman, Débora Braslavsky, Nora Sanguineti, Patricia Pennisi, Rodolfo A Rey, Ignacio Bergadá, Héctor G Jasper, Horacio M Domené, Paola V Plazas, Sabina Domené
Publikováno v:
Human Molecular Genetics.
Growth hormone (GH) binding to GH receptor activates janus kinase 2 (JAK2)-signal transducer and activator of transcription 5b (STAT5b) pathway, which stimulates transcription of insulin-like growth factor-1 (IGF1), insulin-like growth factor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06743fd2ec88849bd672448aeb470936
https://doi.org/10.1093/hmg/ddad078
https://doi.org/10.1093/hmg/ddad078
Autor:
Horacio M, Domené, Vivian, Hwa, Jesús, Argente, Jan M, Wit, Jaan M, Wit, Cecilia, Camacho-Hübner, Héctor G, Jasper, Jesús, Pozo, Hermine A, van Duyvenvoorde, Shoshana, Yakar, Olga V, Fofanova-Gambetti, Ron G, Rosenfeld, Stephen, Rose
Publikováno v:
Hormone research
The majority of insulin-like growth factor (IGF)-I and IGF-II circulate in the serum as a complex with the insulin-like growth factor binding protein (IGFBP)-3 or IGFBP-5, and an acid-labile subunit (ALS). The function of ALS is to prolong the half-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2413cc1875b5b776eb03c8bdb8f5758
https://doi.org/10.1159/000232486
https://doi.org/10.1159/000232486
Autor:
Horacio M, Domené, Paula A, Scaglia, Alicia S, Martínez, Ana C, Keselman, Liliana M, Karabatas, Viviana R, Pipman, Sonia V, Bengolea, María C, Guida, María G, Ropelato, María G, Ballerini, Eva M, Lescano, Miguel A, Blanco, Juan J, Heinrich, Rodolfo A, Rey, Héctor G, Jasper
Publikováno v:
Hormone research in paediatrics. 80(6)
In acid-labile subunit (ALS)-deficient families, heterozygous carriers of IGFALS gene mutations are frequently shorter than their wild-type relatives, suggesting that IGFALS haploinsufficiency could result in short stature. We have characterized IGFA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5425e2a534bf962fb6688ddff6a58e9
https://pubmed.ncbi.nlm.nih.gov/24335034
https://pubmed.ncbi.nlm.nih.gov/24335034
Publikováno v:
Pediatric endocrinology reviews : PER. 7(4)
The acid-labile subunit (ALS) protein is a key component of the circulating 150-kDa IGF ternary complex. The main role of ALS is the extension of IGF-I half life by protecting it from degradation and preventing the passage of IGF-I to the extravascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7e6291705832e3cd0096493d0c2cecf
https://pubmed.ncbi.nlm.nih.gov/20679994
https://pubmed.ncbi.nlm.nih.gov/20679994