Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies

Autor: Durgadevi Parthasarathy, Karunakar Reddy Pothula, Sneha Ratnapriya, Héctor Cervera Benet, Ruth Parsons, Xiao Huang, Salam Sammour, Katarzyna Janowska, Miranda Harris, Joseph Sodroski, Priyamvada Acharya, Alon Herschhorn

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed conformation and infrequently sample open states, limiting access to internal epitopes. Thus, immunogen design aims to mimic the closed Env conformation as pre

Externí odkaz: https://doaj.org/article/586e2ac8dde84379b0e08159c9302824

Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral Entry

Autor: Sneha Ratnapriya, Anthony R. Braun, Héctor Cervera Benet, Danielle Carlson, Shilei Ding, Carolyn N. Paulson, Neeraj Mishra, Jonathan N. Sachs, Courtney C. Aldrich, Andrés Finzi, Alon Herschhorn

Publikováno v: ACS Infectious Diseases. 8:2045-2058

The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells requires binding of the viral spike glycoprotein to the angiotensin-converting enzyme 2 (ACE2) receptor, which triggers subsequent conformational changes to fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5346e498769dac3793e3a1d2b9a34554
https://doi.org/10.1021/acsinfecdis.1c00658

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Slow Receptor Binding of the Noncytopathic HIV-2(UC1) Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity

Autor: Louis M. Mansky, Miranda Harris, Sneha Ratnapriya, Angela Chov, Alisha Block, Joseph Sodroski, Alon Herschhorn, Héctor Cervera, Nathaniel Talledge, Christopher Gu

Publikováno v: Cell Rep

Summary Many HIV strains downregulate the levels of CD4 receptor on the surface of infected cells to prevent superinfection. In contrast, the rare HIV-2UC1 strain is noncytopathic and has no effect on CD4 expression in infected cells but still replic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb4231ac91a7931a64b05e74576d442
https://europepmc.org/articles/PMC7336836/

Viral fitness correlates with the magnitude and direction of the perturbation induced in the host’s transcriptome: the tobacco etch Potyvirus—tobacco case study

Autor: Silvia Ambrós, Guillermo Rodrigo, Héctor Cervera, Santiago F. Elena, Guillermo P. Bernet

Publikováno v: Molecular Biology and Evolution
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
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Digital.CSIC. Repositorio Institucional del CSIC

Determining the fitness of viral genotypes has become a standard practice in virology as it is essential to evaluate their evolutionary potential. Darwinian fitness, defined as the advantage of a given genotype with respect to a reference one, is a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ff0e38a96fafc8b7311552d9debe04
http://hdl.handle.net/10261/184446