Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Hèctor López-Laguna"'
1
Akademický článek
Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids
Autor: Julieta M. Sánchez, Hèctor López‐Laguna, Eloi Parladé, Angela Di Somma, Andrea L. Livieri, Patricia Álamo, Ramón Mangues, Ugutz Unzueta, Antonio Villaverde, Esther Vázquez
Publikováno v: Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Developing time‐sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory granules from the mammalian endocrine system it has generated non‐toxic microscale amyloid materials throug
Externí odkaz: https://doaj.org/article/82a3362efc344234a69090d5067d5d9c
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2
Akademický článek
Enhanced recombinant protein capture, purity and yield from crude bacterial cell extracts by N-Lauroylsarcosine-assisted affinity chromatography
Autor: Jose Vicente Carratalá, Jan Atienza-Garriga, Hèctor López-Laguna, Esther Vázquez, Antonio Villaverde, Julieta M. Sánchez, Neus Ferrer-Miralles
Publikováno v: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Recombinant proteins cover a wide range of biomedical, biotechnological, and industrial needs. Although there are diverse available protocols for their purification from cell extracts or from culture media, many proteins of intere
Externí odkaz: https://doaj.org/article/9713a4788cf54a5b8a92ed1c62cd0932
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3
Akademický článek
Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release
Autor: Laia Bosch-Camós, Carlos Martínez-Torró, Hèctor López-Laguna, Jara Lascorz, Jordi Argilaguet, Antonio Villaverde, Fernando Rodríguez, Esther Vázquez
Publikováno v: Nanomaterials, Vol 14, Iss 5, p 435 (2024)
Developing prolonged antigen delivery systems that mimic long-term exposure to pathogens appears as a promising but still poorly explored approach to reach durable immunities. In this study, we have used a simple technology by which His-tagged protei
Externí odkaz: https://doaj.org/article/276ed246c802422e828eae33267255f0
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4
Akademický článek
Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation
Autor: Naroa Serna, Hèctor López-Laguna, Patricia Aceituno, Mauricio Rojas-Peña, Eloi Parladé, Eric Voltà-Durán, Carlos Martínez-Torró, Julieta M. Sánchez, Angela Di Somma, Jose Vicente Carratalá, Andrea L. Livieri, Neus Ferrer-Miralles, Esther Vázquez, Ugutz Unzueta, Nerea Roher, Antonio Villaverde
Publikováno v: Pharmaceutics, Vol 15, Iss 11, p 2632 (2023)
Both nanostructure and multivalency enhance the biological activities of antimicrobial peptides (AMPs), whose mechanism of action is cooperative. In addition, the efficacy of a particular AMP should benefit from a steady concentration at the local pl
Externí odkaz: https://doaj.org/article/6614a4d6d5cf47b99c1baa1e50c3f41b
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5
Akademický článek
Recombinant Proteins for Assembling as Nano- and Micro-Scale Materials for Drug Delivery: A Host Comparative Overview
Autor: José Luis Corchero, Marianna T. P. Favaro, Merce Márquez-Martínez, Jara Lascorz, Carlos Martínez-Torró, Julieta M. Sánchez, Hèctor López-Laguna, Luís Carlos de Souza Ferreira, Esther Vázquez, Neus Ferrer-Miralles, Antonio Villaverde, Eloi Parladé
Publikováno v: Pharmaceutics, Vol 15, Iss 4, p 1197 (2023)
By following simple protein engineering steps, recombinant proteins with promising applications in the field of drug delivery can be assembled in the form of functional materials of increasing complexity, either as nanoparticles or nanoparticle-leaki
Externí odkaz: https://doaj.org/article/ebb288f008314ec28ce509e30c75cf60
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6
Akademický článek
Ion-dependent slow protein release from in vivo disintegrating micro-granules
Autor: Patricia Álamo, Eloi Parladé, Hèctor López-Laguna, Eric Voltà-Durán, Ugutz Unzueta, Esther Vazquez, Ramon Mangues, Antonio Villaverde
Publikováno v: Drug Delivery, Vol 28, Iss 1, Pp 2383-2391 (2021)
Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be clustered in form of chemically pure and mechanically stable micron-scale particles. Under physiological conditions, these materials act as self-disintegrating
Externí odkaz: https://doaj.org/article/e1e64558485743c29d1660000687a2b5
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7
Akademický článek
The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies
Autor: Julieta María Sánchez, José Vicente Carratalá, Naroa Serna, Ugutz Unzueta, Verónica Nolan, Alejandro Sánchez-Chardi, Eric Voltà-Durán, Hèctor López-Laguna, Neus Ferrer-Miralles, Antonio Villaverde, Esther Vazquez
Publikováno v: Pharmaceutics, Vol 14, Iss 3, p 602 (2022)
The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems. Among them,
Externí odkaz: https://doaj.org/article/3586a23fab1d4a3ab78ac94e6d60dab4
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8
Akademický článek
Artificial Inclusion Bodies for Clinical Development
Autor: Julieta M. Sánchez, Hèctor López‐Laguna, Patricia Álamo, Naroa Serna, Alejandro Sánchez‐Chardi, Verónica Nolan, Olivia Cano‐Garrido, Isolda Casanova, Ugutz Unzueta, Esther Vazquez, Ramon Mangues, Antonio Villaverde
Publikováno v: Advanced Science, Vol 7, Iss 3, Pp n/a-n/a (2020)
Abstract Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow‐protein‐releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these pr
Externí odkaz: https://doaj.org/article/5513d796c3384ddeaffde8c67467fd45
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10
Ion-dependent slow protein release from in vivo disintegrating micro-granules
Autor: Eric Voltà-Durán, Eloi Parladé, Ramon Mangues, Hèctor López-Laguna, Patricia Álamo, Antonio Villaverde, Esther Vázquez, Ugutz Unzueta
Publikováno v: Drug Delivery
article-version (VoR) Version of Record
DRUG DELIVERY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Drug Delivery, Vol 28, Iss 1, Pp 2383-2391 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Through the controlled addition of divalent cations, polyhistidine-tagged proteins can be clustered in form of chemically pure and mechanically stable micron-scale particles. Under physiological conditions, these materials act as self-disintegrating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59e0d0a47ee03657c9eb09b35e5cb12
http://europepmc.org/articles/PMC8584089
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