Výsledky vyhledávání - "Håkan V, Wikström"

Desensitisation of 5-HT autoreceptors upon pharmacokinetically monitored chronic treatment with citalopram

Autor: Thomas I.F.H Cremers, Edwin N Spoelstra, Peter de Boer, Fokko J Bosker, Arne Mørk, Johan A den Boer, Ben H.C Westerink, Håkan V Wikström

Publikováno v: European Journal of Pharmacology, 397(2-3), 351-357. ELSEVIER SCIENCE BV

Rats were chronically treated with the selective serotonin re-uptake inhibitor citalopram [1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phtalancarbonitril], by means of osmotic minipumps. Using an infusion concentration of 50 mg/ml citalopram, stea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090bda730444e26fa717abe75d5f7420
https://hdl.handle.net/11370/0493f831-50e6-40c9-aad6-6eff6bdc47dd

Zobrazit plný text záznamu

The Essential Oil and Valepotriates from Roots of Valeriana javanica Blume Grown in Indonesia

Autor: Herman J. Woerdenbag, Rein Bos, Sidik, Johannes J. C. Scheffer, Håkan V. Wikström, Henk Hendriks

Publikováno v: Flavour and Fragrance Journal, 11(5), 321-326

The volatile constituents isolated from roots of Valeriana javanica Blume, grown in Indonesia, were investigated by GC and GC‐MS (EI) analysis. The roots yielded 0.36% (v/w) essential oil on a dry weight basis. Main constituents of the oil were α�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec70e4d43f51be4f54dd9dc7095511a6
https://doi.org/10.1002/(sici)1099-1026(199609)11:5<321::aid-ffj587>3.0.co

Zobrazit plný text záznamu

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

Autor: Ulrik, Jurva, Håkan V, Wikström, Lars, Weidolf, Andries P, Bruins

Publikováno v: Rapid communications in mass spectrometry : RCM. 17(8)

The extent to which electrochemistry on-line with electrospray mass spectrometry can be used to mimic cytochrome P450 catalyzed oxidations has been investigated. Comparisons on the mechanistic level have been made for most reactions in an effort to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31775c06db35913a5dcde53e7b01c484
https://pubmed.ncbi.nlm.nih.gov/12672134

Zobrazit plný text záznamu

Electrochemically assisted Fenton reaction: reaction of hydroxyl radicals with xenobiotics followed by on-line analysis with high-performance liquid chromatography/tandem mass spectrometry

Autor: Ulrik, Jurva, Håkan V, Wikström, Andries P, Bruins

Publikováno v: Rapid communications in mass spectrometry : RCM. 16(20)

Oxygen radicals are generated in vivo by various processes, often as toxic intermediates in different metabolic transformations, and have been shown to play an important role for a large number of diseases. In this article we introduce an electrochem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::000a9361768feaee3c02dc87c130a871
https://pubmed.ncbi.nlm.nih.gov/12362384

Zobrazit plný text záznamu

A new type of prodrug of catecholamines: An opportunity to improve the treatment of Parkinson's disease

Autor: Bastiaan J, Venhuis, Nienke, Rodenhuis, Håkan V, Wikström, David, Wustrow, Leonard T, Meltzer, Lawrence D, Wise, Stephen J, Johnson, Thomas A, Pugsley, Staffan, Sundell, Durk, Dijkstra

Publikováno v: Journal of Medicinal Chemistry, 45(12), 2349-2351. AMER CHEMICAL SOC
Journal of Medicinal Chemistry, 12(12), 2349-2351. AMER CHEMICAL SOC

After decades of research around dopamine agonists, we have found a promising compound in S-PD148903 that represents a new type of prodrug, which in the rat is bioactivated to the catecholamine S-5,6-diOH-DPAT, known to display mixed dopamine D-1/D-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e4828e586a7f361280cdd648b8de1a
https://research.rug.nl/en/publications/232655e4-3806-4f8b-96e2-10cac83f1b48

Zobrazit plný text záznamu

Stereochemistry-dependent cytotoxicity of some artemisinin derivatives

Autor: Aäron C. Beekman, Adriaan R. W. Barentsen, Herman J. Woerdenbag, Wim Van Uden, Niesko Pras, Antonius W. T. Konings, Farouk S. El-Feraly, Ahmed M. Galal, Håkan V. Wikström

Publikováno v: Journal of natural products. 60(4)

We determined the cytotoxicity of some artemisinin derivatives against EN2 tumor cells using the MTT assay. Artemisinin (1) was clearly more cytotoxic than deoxyartemisinin (2), which lacks the endoperoxide bridge. Ether-linked dimers of dihydroartem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2efea063d124272e1f422c44471788
https://pubmed.ncbi.nlm.nih.gov/9134741

Zobrazit plný text záznamu

Extremely Potent Orally Active Benzo[g]quinoline Analogue of the Dopaminergic Prodrug: 1-Propyl-trans-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo-[g]quinolin-6-one

Autor: Danyang Liu, Håkan V. Wikström, Durk Dijkstra, Jan B. de Vries, Bastiaan J. Venhuis

Publikováno v: Journal of Medicinal Chemistry. 49:6930-6930

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9a9c0d97f662400163739f84e8090fa
https://doi.org/10.1021/jm061084a

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání