Výsledky vyhledávání - "Håkan Norell"

Akademický článek

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

Autor: Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and t

Externí odkaz: https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e6

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Akademický článek

Evaluating in vivo efficacy – toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells

Autor: Inez Johanna, Trudy Straetemans, Sabine Heijhuurs, Tineke Aarts-Riemens, Håkan Norell, Laura Bongiovanni, Alain de Bruin, Zsolt Sebestyen, Jürgen Kuball

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)

Abstract Background γ9δ2T cells, which express Vγ9 and Vδ2 chains of the T cell receptor (TCR), mediate cancer immune surveillance by sensing early metabolic changes in malignant leukemic blast and not their healthy hematopoietic stem counterpart

Externí odkaz: https://doaj.org/article/839223ba97394df696ea6b0bbf9d8090

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Data from DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells

Autor: Karl-Johan Malmberg, Hans-Gustaf Ljunggren, Rolf Kiessling, Kjell Schedvins, Mikael Hanson, Bettina C. Baumann, Thorbald van Hall, Yenan Bryceson, Håkan Norell, Niklas K. Björkström, Mattias Carlsten

Although natural killer (NK) cells are well known for their ability to kill tumors, few studies have addressed the interactions between resting (nonactivated) NK cells and freshly isolated human tumors. Here, we show that human leukocyte antigen clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6893fcffe3ec9639a926bc2cd8718532
https://doi.org/10.1158/0008-5472.c.6495090.v1

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Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

Autor: Nina Schmolka, Maria Gomes da Silva, Tânia Carvalho, Carolina Jardim, Håkan Norell, Bruno Silva-Santos, Francisco Caiado, Ton N. Schumacher, Branka Kolundzija, Cláudia Reforço, Rita Faria, Diogo Maia-Silva, Tuncay Baubec, Christopher R. Vakoc, André E. Simões, Markus G. Manz

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications

Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the complex interplay between altered genetic, epigenetic and transcriptional states in leukemic cells. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8a3b1fd577151236721b50f3ce7348
https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e6

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γδ T cells in cancer

Autor: Karine Serre, Bruno Silva-Santos, Håkan Norell

Publikováno v: Nature Reviews Immunology. 15:683-691

With the promise of T cell-based therapy for cancer finally becoming reality, this Review focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells have well-established protective roles in cancer, largely on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ae62c9a0f8ce1f044e9c583f928394
https://doi.org/10.1038/nri3904

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Author Correction: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

Autor: Tuncay Baubec, Ton N. Schumacher, Cláudia Reforço, Diogo Maia-Silva, Christopher R. Vakoc, Håkan Norell, Carolina Jardim, Tânia Carvalho, Nina Schmolka, Maria Gomes da Silva, Francisco Caiado, André E. Simões, Markus G. Manz, Branka Kolundzija, Rita Faria, Bruno Silva-Santos

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the pape Chemotherapy-resistant cancer recurrence is a major cause of mortality. In acute myeloid leukemia (AML), chemorefractory relapses result from the comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a284508838152efe23d99954a7aaf8a7
https://doaj.org/article/b8f06182e119402593d473bfdd9813b5

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Inhibition of Superoxide Generation upon T-Cell Receptor Engagement Rescues Mart-127-35–Reactive T Cells from Activation-Induced Cell Death

Autor: Christina Voelkel-Johnson, Aaron P. Lesher, Shikhar Mehrotra, Telma Martins da Palma, Navtej Kaur, Nitya G. Chakraborty, Michael I. Nishimura, Håkan Norell, Bijay Mukherji, Osama Naga, Natalie Spivey, Seye Olafimihan, Meenal Mehrotra

Publikováno v: Cancer Research. 69:6282-6289

Cytotoxic T lymphocytes (CTL) may undergo massive expansion upon appropriate antigenic stimulation. Homeostasis is maintained by a subsequent “contraction” of these cells. Activation-induced cell death (AICD) and programmed cell death prevent the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a993e9359f2cb86781901559f1cee812
https://doi.org/10.1158/0008-5472.can-09-1176

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