Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Håkan Mellstedt"'
Autor:
Amineh Ghaderi, Mohammad‐Ali Okhovat, Layung Sekar Sih Wikanthi, Ann Svensson, Marzia Palma, Johan Schultz, Thomas Olin, Anders Österborg, Håkan Mellstedt, Mohammad Hojjat‐Farsangi
Publikováno v:
eJHaem, Vol 2, Iss 3, Pp 498-502 (2021)
Abstract ROR1 – a receptor tyrosine kinase – is overexpressed in CLL. Ibrutinib, a Bruton's tyrosine kinase inhibitor, is clinically effective in CLL but patients may develop resistance. We evaluated the effect of an ROR1 inhibitor, KAN0441571C,
Externí odkaz:
https://doaj.org/article/0aa8be017263486cb8f895e3be923506
Autor:
Jeanette Lundin, Tom A. Mulder, Magdalena Kättström, Tove Wästerlid, Anders Uddevik, Håkan Mellstedt, Kia Heimersson, Lotta Hansson, Marzia Palma, Anders Österborg
Publikováno v:
eJHaem, Vol 2, Iss 3, Pp 525-529 (2021)
Abstract Ibrutinib is used continuously in CLL. This phase 1b/2 study interim analysis explored on‐off‐repeat dosing to reduce toxicity. After 12 months, 16/22 patients (73%) remained in first off‐phase irrespective if initial CR/PR or TP53 abe
Externí odkaz:
https://doaj.org/article/7f328d6a737444259549a86a1865a7f1
Autor:
Amineh Ghaderi, Mohammad-Ali Okhovat, Jemina Lehto, Luigi De Petris, Ehsan Manouchehri Doulabi, Parviz Kokhaei, Wen Zhong, Georgios Z. Rassidakis, Elias Drakos, Ali Moshfegh, Johan Schultz, Thomas Olin, Anders Österborg, Håkan Mellstedt, Mohammad Hojjat-Farsangi
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1148 (2023)
The ROR1 receptor tyrosine kinase is expressed in embryonic tissues but is absent in normal adult tissues. ROR1 is of importance in oncogenesis and is overexpressed in several cancers, such as NSCLC. In this study, we evaluated ROR1 expression in NSC
Externí odkaz:
https://doaj.org/article/1287c54575b8479d88d0bd97b869a154
Autor:
Walter Z. Wang, Konstantin Shilo, Joseph M. Amann, Alyssa Shulman, Mohammad Hojjat-Farsangi, Håkan Mellstedt, Johan Schultz, Carlo M. Croce, David P. Carbone
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-9 (2021)
Abstract Small cell lung cancer (SCLC) remains a deadly form of cancer, with a 5-year survival rate of less than 10 percent, necessitating novel therapies. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein that is emergin
Externí odkaz:
https://doaj.org/article/8e3d803832bd442687414f1eec0b50ef
Autor:
Amineh Ghaderi, Wen Zhong, Mohammad Ali Okhovat, Johanna Aschan, Ann Svensson, Birgitta Sander, Johan Schultz, Thomas Olin, Anders Österborg, Mohammad Hojjat-Farsangi, Håkan Mellstedt
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2238 (2022)
The receptor tyrosine kinase orphan receptor 1 (ROR1) is absent in most normal adult tissues but overexpressed in various malignancies and is of importance for tumor cell survival, proliferation, and metastasis. In this study, we evaluated the apopto
Externí odkaz:
https://doaj.org/article/1ddf361c3275497c927bb40fd3abd27c
Autor:
Amineh Ghaderi, Amir Hossein Daneshmanesh, Ali Moshfegh, Parviz Kokhaei, Jan Vågberg, Johan Schultz, Thomas Olin, Sara Harrysson, Karin E Smedby, Elias Drakos, Georgios Z. Rassidakis, Anders Österborg, Håkan Mellstedt, Mohammad Hojjat-Farsangi
Publikováno v:
Biomedicines, Vol 8, Iss 6, p 170 (2020)
The receptor tyrosine kinase ROR1 is absent in most normal adult tissues, but overexpressed in several malignancies. In this study, we explored clinical and functional inhibitory aspects of ROR1 in diffuse large B-cell lymphoma (DLBCL). ROR1 expressi
Externí odkaz:
https://doaj.org/article/d36a9e454ef446bc87fdc28c52d68ddd
Autor:
Parviz Kokhaei, Mohammad Hojjat-Farsangi, Fariba Mozaffari, Ali Moshfegh, Fatemeh Pak, Ali Rashidy-Pour, Marzia Palma, Lotta Hansson, Anders Österborg, Håkan Mellstedt
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192839 (2018)
Crosstalk between leukemic cells and the tumor microenvironment is of importance in chronic lymphocytic leukemia (CLL). T cells seem to sustain the survival of CLL cells by various mechanisms. The Krüppel-like family of transcription factors (KLFs)
Externí odkaz:
https://doaj.org/article/fcdf895cba0b43c5a53915ce617f4a25
Autor:
Amir Hossein Daneshmanesh, Mohammad Hojjat-Farsangi, Amineh Ghaderi, Ali Moshfegh, Lotta Hansson, Johan Schultz, Jan Vågberg, Styrbjörn Byström, Elisabeth Olsson, Thomas Olin, Anders Österborg, Håkan Mellstedt
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198038 (2018)
There is a great unmet medical need in pancreatic carcinoma (PC) for novel drugs with other mechanisms of action than existing. PC cells express the onco-fetal RTK ROR1, absent on most normal post-partem cells. ROR1 is involved in proliferation, surv
Externí odkaz:
https://doaj.org/article/8743e38417724615841dfe2b2b650da9
Autor:
Richard E Kast, Quentin A Hill, Didier Wion, Håkan Mellstedt, Daniele Focosi, Georg Karpel-Massler, Tim Heiland, Marc-Eric Halatsch
Publikováno v:
Tumor Biology, Vol 39 (2017)
Increased ratio of circulating neutrophils to lymphocytes is a common finding in glioblastoma and other cancers. Data reviewed establish that any damage to brain tissue tends to cause an increase in G-CSF and/or GM-CSF (G(M)-CSF) synthesized by the b
Externí odkaz:
https://doaj.org/article/1f37184334fb4ccbbd7dd8ef9dd87e85
Autor:
Marzia Palma, Giusy Gentilcore, Kia Heimersson, Fariba Mozaffari, Barbro Näsman-Glaser, Emma Young, Richard Rosenquist, Lotta Hansson, Anders Österborg, Håkan Mellstedt
Publikováno v:
Haematologica, Vol 102, Iss 3 (2017)
Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to profound T-cell defects. T-cell functions also depend on co-signaling receptors, inhibitory or stimulatory, known as immune checkpoints, including cytotoxic T-l
Externí odkaz:
https://doaj.org/article/352e8ed1603e4fb9a9631e639b29610e