Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Håkan Hedman"'
Autor:
Emelie Karlsson, Rikard Hanafi, Helena Brisby, Andreas Fors, Mike Kemani, Håkan Hedman, Jo Nijs, Mari Lundberg
Publikováno v:
Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Background Spinal stenosis is the most common reason for elective spine surgery, and the cardinal symptom is leg pain and discomfort when walking. Patients with spinal stenosis have a decreased level of physical activity and thereby an incre
Externí odkaz:
https://doaj.org/article/1897d26b19c44aaca4101f042ca35738
Autor:
Adam Rosenbaum, Anna M. Dahlin, Ulrika Andersson, Benny Björkblom, Wendy Yi-Ying Wu, Håkan Hedman, Carl Wibom, Beatrice Melin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Genome-wide association studies (GWAS) have contributed to our understanding of glioma susceptibility. To date, 25 risk loci for development of any of the glioma subtypes are known. However, GWAS studies reveal little about the molecular pro
Externí odkaz:
https://doaj.org/article/fd0f3a703d9e4e7c89cbe908bd914f26
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0289726 (2023)
Leucine-rich repeats and immunoglobulin-like domains (LRIG) are transmembrane proteins shown to promote bone morphogenetic protein (BMP) signaling in Caenorhabditis elegans, Drosophila melanogaster, and mammals. BMPs comprise a subfamily of the trans
Externí odkaz:
https://doaj.org/article/65602ebf251f43d2b19bd7ce7e413980
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Netrin-1 is a secreted protein that is well known for its involvement in axonal guidance during embryonic development and as an enhancer of cancer cell metastasis. Despite extensive efforts, the molecular mechanisms behind many of the physio
Externí odkaz:
https://doaj.org/article/28591f96dd0a4e8aaa555ae108212a98
Autor:
Carl Herdenberg, Pascal M. Mutie, Ola Billing, Ahmad Abdullah, Rona J. Strawbridge, Ingrid Dahlman, Simon Tuck, Camilla Holmlund, Peter Arner, Roger Henriksson, Paul W. Franks, Håkan Hedman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and
Externí odkaz:
https://doaj.org/article/2dabfe4ef579463aa23b059fe23b8acc
Autor:
Mahmood Faraz, Andreas Tellström, Christina Edwinsdotter Ardnor, Kjell Grankvist, Lukasz Huminiecki, Björn Tavelin, Roger Henriksson, Håkan Hedman, Ingrid Ljuslinder
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) copy number alterations and unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, LRIG1 loss was recently shown to predict ea
Externí odkaz:
https://doaj.org/article/deae4120240c4efd9609f400a550d352
Autor:
Cecilia Ranhem, Gabriella Lillsunde Larsson, Håkan Hedman, David Lindquist, Mats G Karlsson, Ann-Cathrin Hellström, Ellinor Östensson, Bengt Sorbe, Kristina Hellman, Sonia Andersson
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183816 (2017)
Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is k
Externí odkaz:
https://doaj.org/article/d9d637b7ec124c1bbea2263e51cb875e
Autor:
Veronica Rondahl, Camilla Holmlund, Terese Karlsson, Baofeng Wang, Mahmood Faraz, Roger Henriksson, Håkan Hedman
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73635 (2013)
BACKGROUND: The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, and LRIG3. LRIG1 negatively regulates growth factor signaling, but little is kno
Externí odkaz:
https://doaj.org/article/3c27387ff4514007aa178108e3f9034b
Autor:
Beatrice S. Melin, Melissa L. Bondy, Roger Henriksson, Håkan Hedman, Aysegul Sahin, Abenaa Brewster, Spyros Tsavachidis, Ingrid Ljuslinder, Patricia A. Thompson
Gains and losses at chromosome 3p12-21 are common in breast tumors and associated with patient outcomes. We hypothesized that the LRIG1 gene at 3p14.1, whose product functions in ErbB-family member degradation, is a critical tumor modifier at this lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd773a0d50e38a51f13d7f9da607d02
https://doi.org/10.1158/0008-5472.c.6505053.v1
https://doi.org/10.1158/0008-5472.c.6505053.v1
Autor:
Beatrice S. Melin, Melissa L. Bondy, Roger Henriksson, Håkan Hedman, Aysegul Sahin, Abenaa Brewster, Spyros Tsavachidis, Ingrid Ljuslinder, Patricia A. Thompson
The supplemental files provide details on the specific sub-studies used in the expression based replication analysis as well as detailed information on LRIG1 probe location on the MIP array and sensitivity analyses that were conducted relative to tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e95f4388119a095a65f486659f4e38b
https://doi.org/10.1158/0008-5472.22398357
https://doi.org/10.1158/0008-5472.22398357