Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Håkan C. Steen"'
Autor:
Shoko Nogusa, Håkan C. Steen, Michele Y. Harris, Siddharth Balachandran, Kevin P. Kotredes, Ana M. Gamero
Publikováno v:
Journal of Cell Science.
Serine phosphorylation of STAT proteins is an important post-translational modification event that, in addition to tyrosine phosphorylation, is required for strong transcriptional activity. However, we recently showed that phosphorylation of STAT2 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffad030d268b07579a7b7c7c6203cdef
https://doi.org/10.1242/jcs.185421
https://doi.org/10.1242/jcs.185421
Autor:
Ana M. Gamero, Håkan C. Steen
Publikováno v:
Journal of Interferon & Cytokine Research. 32:103-110
The signal transducer and activator of transcription-2 (STAT2) was discovered as a cellular component of the DNA binding complex known as interferon (IFN) stimulated gene factor-3. Numerous studies have confirmed that STAT2 operates as a positive reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a4692789d9d5a55e22872467cf01ab
https://doi.org/10.1089/jir.2011.0099
https://doi.org/10.1089/jir.2011.0099
Autor:
Ana M. Gamero, Håkan C. Steen
Publikováno v:
JAK-STAT
STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015445aa72499a845192655ba29a5809
http://europepmc.org/articles/PMC3876438
http://europepmc.org/articles/PMC3876438
Autor:
Shoko Nogusa, Amanda L. Gill, Suresh H. Basagoudanavar, Salim Merali, Roshan J. Thapa, Håkan C. Steen, Siddharth Balachandran, Carlos A. Barrero, Ana M. Gamero
Publikováno v:
The Journal of biological chemistry. 288(1)
STAT2 is a positive modulator of the transcriptional response to type I interferons (IFNs). STAT2 acquires transcriptional function by becoming tyrosine phosphorylated and imported to the nucleus following type I IFN receptor activation. Although mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91247ddc54bef961b828a0f6ee8c9ff0
https://pubmed.ncbi.nlm.nih.gov/23139419
https://pubmed.ncbi.nlm.nih.gov/23139419
Autor:
Ana M. Gamero, Håkan C. Steen
Publikováno v:
J Interferon Cytokine Res
The discovery that type I interferon (IFN-alpha/beta) inhibited tumor cell growth was welcomed initially with great excitement as it rapidly became a U.S. Food and Drug Administration-approved drug to treat several forms of cancer. In time, this enth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7902435c841cba7088c74114653329c8
https://pubmed.ncbi.nlm.nih.gov/20645876
https://pubmed.ncbi.nlm.nih.gov/20645876
Autor:
Faruk Sheikh, Ana M. Gamero, Raymond P. Donnelly, Hsiang-Wen Wang, Anthony J. Scarzello, Håkan C. Steen, Ana L. Romero-Weaver, Veronica L. Hall
Publikováno v:
Molecular cancer research : MCR. 8(1)
Type I IFNs (IFN-α/β) are pleitropic cytokines widely used in the treatment of certain malignancies, hepatitis B and C, and multiple sclerosis. IFN resistance is a challenging clinical problem to overcome. Hence, understanding the molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be582a65b59e59d10b2bc83e97ae91d
https://pubmed.ncbi.nlm.nih.gov/20068068
https://pubmed.ncbi.nlm.nih.gov/20068068
Autor:
Ana M. Gamero, Håkan C. Steen
Publikováno v:
Cytokine. 48:128-129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a81420d6cbde93971081fcf2f22576ed
https://doi.org/10.1016/j.cyto.2009.07.544
https://doi.org/10.1016/j.cyto.2009.07.544
Autor:
Håkan C. Steen, Ana M. Gamero, Roshan J. Thapa, Suresh H. Basagoudanavar, Siddharth Balachandran
Publikováno v:
Cytokine. 52:31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22a472ed1bcb704d3add5cd602f42d95
https://doi.org/10.1016/j.cyto.2010.07.138
https://doi.org/10.1016/j.cyto.2010.07.138
Autor:
Håkan C. Steen, Ana M. Gamero
Publikováno v:
Journal of Interferon & Cytokine Research; Aug2010, Vol. 30 Issue 8, p597-602, 6p