Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Håkan, Westerblad"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Muscle fiber force production is determined by the excitation frequency of motor nerves, which induce transient increases in cytoplasmic free Ca2+ concentration ([Ca2+]i) and the force-generating capacity of the actomyosin cross-bridges. Pre
Externí odkaz:
https://doaj.org/article/6dfb5485f73b4b6fb19dcf1020b41c03
Autor:
Karl Olsson, Arthur J. Cheng, Mamdoh Al‐Ameri, Nicolas Tardif, Michael Melin, Olav Rooyackers, Johanna T. Lanner, Håkan Westerblad, Thomas Gustafsson, Joseph D. Bruton, Eric Rullman
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 5, Pp 2551-2561 (2022)
Abstract Background Activation of sphingomyelinase (SMase) as a result of a general inflammatory response has been implicated as a mechanism underlying disease‐related loss of skeletal muscle mass and function in several clinical conditions includi
Externí odkaz:
https://doaj.org/article/7fb1498589644ddc99e83f9465b8952c
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102260- (2023)
Summary: Here, we provide a protocol for isolation of mouse primary skeletal muscle fibers using two alternative approaches—enzymatic dissociation or mechanical microdissection. We describe the procedures for surgical removal of muscle of interest
Externí odkaz:
https://doaj.org/article/51845cdcad344350be0a73a7630e3a64
Autor:
Takashi Yamada, Yuki Ashida, Katsuyuki Tamai, Iori Kimura, Nao Yamauchi, Azuma Naito, Nao Tokuda, Håkan Westerblad, Daniel C. Andersson, Koichi Himori
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Muscle weakness and decreased fatigue resistance are key manifestations of systemic autoimmune myopathies (SAMs). We here examined whether high-intensity interval training (HIIT) improves fatigue resistance in the skeletal muscle
Externí odkaz:
https://doaj.org/article/f3a73cf6893a4a8090902e7d6619f96a
Autor:
Charlotte Gineste, Sonia Youhanna, Sabine U. Vorrink, Sara Henriksson, Andrés Hernández, Arthur J. Cheng, Thomas Chaillou, Andreas Buttgereit, Dominik Schneidereit, Oliver Friedrich, Kjell Hultenby, Joseph D. Bruton, Niklas Ivarsson, Linda Sandblad, Volker M. Lauschke, Håkan Westerblad
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105654- (2022)
Summary: Cells rapidly lose their physiological phenotype upon disruption of their extracellular matrix (ECM)-intracellular cytoskeleton interactions. By comparing adult mouse skeletal muscle fibers, isolated either by mechanical dissection or by col
Externí odkaz:
https://doaj.org/article/28a20786507944e29cd08fe6371fe36e
Autor:
Tomas Venckunas, Marius Brazaitis, Audrius Snieckus, Mantas Mickevicius, Nerijus Eimantas, Andrejus Subocius, Dalia Mickeviciene, Håkan Westerblad, Sigitas Kamandulis
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 16 (2022)
Inactivity is known to induce muscle weakness, and chronically increased levels of reactive oxygen species (ROS) are proposed to have a central causative role in this process. Intriguingly, high-intensity interval training (HIIT), which involves burs
Externí odkaz:
https://doaj.org/article/598d01bf77ca44dbac6c14d3671855f1
Autor:
Benjamin Chatel, Sylvie Ducreux, Zeina Harhous, Nadia Bendridi, Isabelle Varlet, Augustin C. Ogier, Monique Bernard, Julien Gondin, Jennifer Rieusset, Håkan Westerblad, David Bendahan, Charlotte Gineste
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 9 (2021)
Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscl
Externí odkaz:
https://doaj.org/article/1d6c38b12e5640108ab99eb5d7016953
Autor:
Sabine Lotteau, PhD, Niklas Ivarsson, PhD, Zhaokang Yang, PhD, Damien Restagno, PhD, John Colyer, PhD, Philip Hopkins, MD, Andrew Weightman, PhD, Koichi Himori, MSc, Takashi Yamada, PhD, Joseph Bruton, PhD, Derek Steele, PhD, Håkan Westerblad, MD, PhD, Sarah Calaghan, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 4, Pp 509-523 (2019)
Summary: This study aimed to identify a mechanism for statin-induced myopathy that explains its prevalence and selectivity for skeletal muscle, and to understand its interaction with moderate exercise. Statin-associated adverse muscle symptoms reduce
Externí odkaz:
https://doaj.org/article/78f53b25bad64710b444c80cfadf25d9
Autor:
Victoria L. Wyckelsma, Ada Trepci, Lilly Schwieler, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Henrikas Paulauskas, Helena Gapeyeva, Mati Pääsuke, Stefano Gastaldello, Sophie Imbeault, Håkan Westerblad, Sophie Erhardt, Daniel C. Andersson
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1443 (2021)
The kynurenine pathway (KP) is gaining attention in several clinical fields. Recent studies show that physical exercise offers a therapeutic way to improve ratios of neurotoxic to neuroprotective KP metabolites. Antioxidant supplementation can blunt
Externí odkaz:
https://doaj.org/article/f760465f5aa14e12a6a0791f064484d8
Autor:
Cecilia Leijding, Ida Viken, Joseph D. Bruton, Daniel C. Andersson, Arthur J. Cheng, Håkan Westerblad
Publikováno v:
The FASEB Journal. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be151951fd81761cd8677f25d728b16c
https://doi.org/10.1096/fj.202300401r
https://doi.org/10.1096/fj.202300401r