miR-16 and miR-103 impact 5-HT 4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

Autor: Wohlfarth C; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Schmitteckert S; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Härtle JD; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Houghton LA; University of Leeds, St. James's University Hospital, LS97TF, Leeds, UK.; Mayo Clinic, Jacksonville, FL, 32224, USA., Dweep H; Medical Research Centre, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, 68167, Germany.; Division of Bioinformatics and Biostatistics, National Centre for Toxicological Research, U.S. Food and Drug Administration (FDA), Jefferson, AR, 72079, USA., Fortea M; Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain., Assadi G; Department of Biosciences and Nutrition, Karolinska Institutet, 17177, Stockholm, Sweden., Braun A; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Mederer T; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Pöhner S; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Becker PP; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Fischer C; Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Granzow M; Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Mönnikes H; Martin-Luther-Hospital, 14193, Berlin-Grunewald, Germany., Mayer EA; Oppenheimer Centre for Neurobiology of Stress, Division of Digestive Diseases, University of California, Los Angeles, CA 90095-7378, USA., Sayuk G; Washington University School of Medicine, St. Louis, MO, 63110, USA., Boeckxstaens G; TARGID, University Hospital Leuven, 3000, Leuven, Belgium., Wouters MM; TARGID, University Hospital Leuven, 3000, Leuven, Belgium., Simrén M; Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345, Gothenburg, Sweden., Lindberg G; Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Huddinge, 17176, Stockholm, Sweden., Ohlsson B; Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, 22241, Lund, Sweden., Schmidt PT; Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, 14186, Stockholm, Sweden., Dlugosz A; Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Huddinge, 17176, Stockholm, Sweden., Agreus L; Division for Family Medicine and Primary Care, Karolinska Institutet, 14183, Huddinge, Sweden., Andreasson A; Department of Medicine, Solna, Karolinska Institutet, 171 76, Solna, Sweden.; Stress Research Institute, Stockholm University, 10691, Stockholm, Sweden., D'Amato M; Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, 171 76, Stockholm, Sweden.; BioDonostia Health Research Institute, San Sebastian and Ikerbasque, Basque Science Foundation, 48013, Bilbao, Spain., Burwinkel B; Molecular Epidemiology Group, German Cancer Research Centre (DKFZ), Heidelberg, Germany.; Division of Molecular Biology of Breast Cancer, Department of Gynaecology and Obstetrics, University Women's Clinic, University of Heidelberg, 69120, Heidelberg, Germany., Bermejo JL; Institute of Medical Biometry and Informatics, University of Heidelberg, 69120, Heidelberg, Germany., Röth R; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.; nCounter Core Facility, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Lasitschka F; Institute of Pathology, University of Heidelberg, 69120, Heidelberg, Germany., Vicario M; Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain., Metzger M; Department Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, 97082, Wuerzburg, Germany.; Translational Centre 'Regenerative Therapies for Oncology and Musculoskeletal Diseases' (TZKME), Branch of the Fraunhofer Institute Interfacial Engineering and Biotechnology (IGB) Wuerzburg, 97082, Wuerzburg, Germany., Santos J; Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain., Rappold GA; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany., Martinez C; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany.; Digestive System Research Unit, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Facultat de Medicina), 08035, Barcelona, Spain., Niesler B; Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany. beate.niesler@med.uni-heidelberg.de.; nCounter Core Facility, Institute of Human Genetics, University of Heidelberg, 69120, Heidelberg, Germany. beate.niesler@med.uni-heidelberg.de.

Publikováno v: Scientific reports [Sci Rep] 2017 Oct 31; Vol. 7 (1), pp. 14680. Date of Electronic Publication: 2017 Oct 31.