Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Hägebarth A"'
Autor:
Gradl, Stefan *, Steuber, Holger, Weiske, Joerg, Szewczyk, Magda M., Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Abbey, Megha, Kennedy, Steven, Chau, Irene, Trush, Viacheslav, Barsyte-Lovejoy, Dalia, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl, Husemann, Manfred, Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo **
Publikováno v:
In SLAS Discovery September 2021 26(8):947-960
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
The lactate transporter SLC16A1/monocarboxylate transporter 1 (MCT1) plays a central role in tumor cell energy homeostasis. In a cell-based screen, we identified a novel class of MCT1 inhibitors, including BAY-8002, which potently suppress bidirectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc176275426db1e8e7d752f623ce531
https://doi.org/10.1158/1535-7163.c.6537978.v1
https://doi.org/10.1158/1535-7163.c.6537978.v1
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
Supplementary Methods: Synthesis and characterization of BAY-8002; Tritium labeling of AZD3965 and BAY-8002; MCT1 and MCT4 14C-lactate uptake measurements in the X. laevis oocytes expression System
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c449390e8d6d58b8fd14c10da3442
https://doi.org/10.1158/1535-7163.22505181
https://doi.org/10.1158/1535-7163.22505181
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
Supplemental Table S1: Selectivity profile of BAY-8002. Supplemental Table S2: Summary table of functional and proliferation IC50 data for BAY-8002 and AZD3965. Supplemental Table S3: Responses to BAY-8002 and AZD3965 of cell lines with acquired resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4b47918c194f9c7b520dda50e82cba
https://doi.org/10.1158/1535-7163.22505184.v1
https://doi.org/10.1158/1535-7163.22505184.v1
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
Supplemental Figure S1: A, SLC16A1 (MCT1), SLC16A7 (MCT2), SLC16A8 (MCT3) and SLC16A3 (MCT4) mRNA expression levels and Effects of BAY-8002 on lactate Export and ECAR. Supplemental Figure S2: Binding affinity of the two MCT1 inhibitors BAY-8002 and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f37e408a23840755a8e7e27d10ad6b
https://doi.org/10.1158/1535-7163.22505187
https://doi.org/10.1158/1535-7163.22505187
Autor:
Andrea Hägebarth, Carl Friedrich Nising, Philip Lienau, Julien Lefranc, Benjamin Bader, Clara D. Christ, Volker K Schulze, Clara Lemos, Simon Holton, Tobias Heinrich, Ulf Bömer, Franz von Nussbaum, Hans Briem, Ekaterina Nevedomskaya, Simon J. Baumgart, Dominik Mumberg, Bernard Haendler, Marcus Bauser, Lara Kuhnke
Publikováno v:
Cellular Oncology. 44:581-594
5′ adenosine monophosphate-activated kinase (AMPK) is an essential regulator of cellular energy homeostasis and has been associated with different pathologies, including cancer. Precisely defining the biological role of AMPK necessitates the availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c3ebc06fe1821f53c3d1ac1c328fe0
https://doi.org/10.1007/s13402-020-00584-8
https://doi.org/10.1007/s13402-020-00584-8
Autor:
Ilya Kovalenko, Andrea Glasauer, Laura Schöckel, Daniel R P Sauter, Alexander Ehrmann, Florian Sohler, Andrea Hägebarth, Ivana Novak, Sven Christian
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160658 (2016)
Pancreatic ductal adenocarcinoma (PDAC) represents the most common form of pancreatic cancer with rising incidence in developing countries and overall 5-year survival rates of less than 5%. The most frequent mutations in PDAC are gain-of-function mut
Externí odkaz:
https://doaj.org/article/e63e7cb8f89e4e568fe964d4b2f09d6a
Autor:
Snippert, Hugo J., Haegebarth, Andrea, Kasper, Maria, Jaks, Viljar, van Es, Johan H., Barker, Nick, van de Wetering, Marc, van den Born, Maaike, Begthel, Harry, Vries, Robert G., Stange, Daniel E., Toftgård, Rune, Clevers, Hans
Publikováno v:
Science, 2010 Mar 01. 327(5971), 1385-1389.
Externí odkaz:
https://www.jstor.org/stable/40544619
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
In Gastroenterology 2009 137(3):945-954