Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Häfner AK"'
Autor:
Ann-Kathrin Häfner, Jasmin Fettel, Estel.la Buscató, Isabelle V. Maucher, Juliana Heidler, Jessica Roos, Anja Vogel, Michael J. Parnham, Ilka Wittig, Camilla Brat, Ewgenij Proschak, Gerd Geisslinger, Marcus Peters, Kai Zacharowski, Thorsten J. Maier, Carmela Matrone, Nadine Hellmuth, Anja Urbschat, Dieter Steinhilber, Benita Sommer, Benjamin Kühn, René Blöcher, Matthias Piesche, Oliver Werz, Carlo Angioni
Publikováno v:
Roos, J, Peters, M, Maucher, I V, Kühn, B, Fettel, J, Hellmuth, N, Brat, C, Sommer, B, Urbschat, A, Piesche, M, Vogel, A, Proschak, E, Blöcher, R, Buscato, E L, Häfner, A-K, Matrone, C, Werz, O, Heidler, J, Wittig, I, Angioni, C, Geisslinger, G, Parnham, M J, Zacharowski, K, Steinhilber, D & Maier, T J 2018, ' Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase : a possible key to future anti-leukotriene therapy ', Antioxidants & Redox Signaling, vol. 28, no. 14, pp. 1265-1285 . https://doi.org/10.1089/ars.2017.7155
AIMS: 5-lipoxygenase (5-LO) is the key enzyme of leukotriene biosynthesis and is critically involved in a number of inflammatory diseases such as arthritis, gout, bronchial asthma, atherosclerosis and cancer. Because 5-LO contains critical nucleophil
Autor:
Carmela Matrone, Vahid Golghalyani, Isabelle V. Maucher, Michael Rühl, Nadine Hellmuth, Jessica Roos, Matthias Piesche, Ann-Katrin Ball, Michael Karas, Simon B.M. Kretschmer, Ann-Kathrin Häfner, Bettina Hofmann, Georg Manolikakes, Anja Vogel, Benjamin Kühn, Gerd Geisslinger, Thorsten J. Maier, Dieter Steinhilber, Karsten T. Flügel, Jasmin Fettel, Michael J. Parnham
Publikováno v:
Maucher, I V, Rühl, M, Bm Kretschmer, S, Hofmann, B, Kühn, B, Fettel, J, Vogel, A, Flügel, K T, Manolikakes, G, Hellmuth, N, Häfner, A-K, Golghalyani, V, Ball, A-K, Piesche, M, Matrone, C, Geisslinger, G, Parnham, M J, Karas, M, Steinhilber, D, Roos, J & Maier, T J 2017, ' Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418 ', Biochemical Pharmacology, vol. 125, no. 1, pp. 55–74 . https://doi.org/10.1016/j.bcp.2016.11.004
Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting with catalytically cysteine residues next to a substrate entry channel. The electrophilicity is derived from an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4ad1c8a0f902beeef1909da6d7f352
https://publica.fraunhofer.de/handle/publica/252024
https://publica.fraunhofer.de/handle/publica/252024
Autor:
Molitor M; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany., Menge A; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany.; Buchmann Institute for Molecular Life Sciences and Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt Am Main, Germany., Mandel S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany., George S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany., Müller S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany.; Buchmann Institute for Molecular Life Sciences and Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt Am Main, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany.; Buchmann Institute for Molecular Life Sciences and Structural Genomics Consortium (SGC), Max-von-Laue-Str. 15, 60438, Frankfurt Am Main, Germany., Hofmann B; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt Am Main, Germany. haefner@pharmchem.uni-frankfurt.de.
Publikováno v:
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Sep 30. Date of Electronic Publication: 2024 Sep 30.
Autor:
Kahnt AS; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany. kahnt@pharmchem.uni-frankfurt.de., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany.
Publikováno v:
Oncogene [Oncogene] 2024 May; Vol. 43 (18), pp. 1319-1327. Date of Electronic Publication: 2024 Apr 04.
Autor:
Weisser H; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany., Göbel T; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany., Melissa Krishnathas G; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany., Kreiß M; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany., Angioni C; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany., Sürün D; Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, 01307, Dresden, Germany., Thomas D; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, ZAFES, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.; Fraunhofer Institute of Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596, Frankfurt/Main, Germany., Schmid T; Institute of Biochemistry I, Faculty of Medicine, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany., Kahnt AS; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438, Frankfurt/Main, Germany. kahnt@pharmchem.uni-frankfurt.de.
Publikováno v:
Cancer gene therapy [Cancer Gene Ther] 2023 Jan; Vol. 30 (1), pp. 108-123. Date of Electronic Publication: 2022 Sep 16.
Autor:
Kreiß M; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Oberlis JH; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Seuter S; Institute for Cardiovascular Physiology, Goethe University, Medical Faculty, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany., Bischoff-Kont I; Institute of Pharmaceutical Biology, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Sürün D; Medical Systems Biology, UCC,TU Dresden, Medical Faculty Carl Gustav Carus, Fetscherstr. 74, 01307 Dresden, Germany., Thomas D; Institute for Clinical Pharmacology, Goethe University, Medical Faculty, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany., Göbel T; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Schmid T; Institute of Biochemistry I, Goethe University, Medical Faculty, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany., Rådmark O; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-17177 Stockholm, Sweden., Brandes RP; Institute for Cardiovascular Physiology, Goethe University, Medical Faculty, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany., Fürst R; Institute of Pharmaceutical Biology, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany. Electronic address: haefner@pharmchem.uni-frankfurt.de., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany. Electronic address: steinhilber@em.uni-frankfurt.de.
Publikováno v:
Biochemical pharmacology [Biochem Pharmacol] 2022 Sep; Vol. 203, pp. 115187. Date of Electronic Publication: 2022 Jul 22.
Autor:
Uebbing S; Department of Biology, Technical University, Darmstadt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany.; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Kreiß M; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany., Scholl F; Department of Biology, Technical University, Darmstadt, Germany.; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany.; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany., Sürün D; Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany., Garscha U; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany., Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, Jena, Germany., Basavarajappa D; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Samuelsson B; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Rådmark O; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Suess B; Department of Biology, Technical University, Darmstadt, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt/Main, Germany.
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21193. Date of Electronic Publication: 2020 Nov 17.
Autor:
Dufrusine B; Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy., Di Francesco A; Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy., Oddi S; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.; European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Rome, Italy., Scipioni L; European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Rome, Italy., Angelucci CB; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy., D'Addario C; Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy., Serafini M; Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany., Maccarrone M; European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Rome, Italy.; Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy., Dainese E; Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy.; European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Rome, Italy.
Publikováno v:
Frontiers in immunology [Front Immunol] 2019 Jun 28; Vol. 10, pp. 1347. Date of Electronic Publication: 2019 Jun 28 (Print Publication: 2019).
Autor:
Häfner AK; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Kahnt AS; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany. Electronic address: steinhilber@em.uni-frankfurt.de.
Publikováno v:
Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2019 Jun; Vol. 142, pp. 24-32. Date of Electronic Publication: 2019 Mar 28.
Autor:
Nejatian N; Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, Frankfurt am Main, Germany. Electronic address: Nojan.Nejatian@kgu.de., Häfner AK; Institute of Pharmaceutical Chemistry, University of Frankfurt, Frankfurt am Main, Germany., Shoghi F; Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, Frankfurt am Main, Germany., Badenhoop K; Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, Frankfurt am Main, Germany., Penna-Martinez M; Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, Frankfurt am Main, Germany.
Publikováno v:
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2019 Mar; Vol. 187, pp. 52-57. Date of Electronic Publication: 2018 Dec 03.