Výsledky vyhledávání - "H»kan Wikström"

Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties

Autor: Kjell Svensson, Nicholas Waters, Clas Sonesson, J. Neil Duncan, Arvid Carlsson, H»kan Wikström, M. W. Smith, Chiu-Hong Lin, Susanne R. Haadsma-Svensson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:689-694

A series of (+)-AJ76 and (+)-UH232 analogs with the C-5 methoxy group modified was synthesized and biologically evaluated. Compounds with a triflate or nitrile group were found to be behavioral stimulants with high metabolic stability. The triflate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::424a5e415ffdb26beddfb35c84ee134c
https://doi.org/10.1016/s0960-894x(01)80181-5

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