Zobrazeno 1 - 10 of 433 pro vyhledávání: '"H, Wilkes"'
1
Akademický článek
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
Autor: Abbie E. Fearon, Edward P. Carter, Natasha S. Clayton, Edmund H. Wilkes, Ann-Marie Baker, Ekaterina Kapitonova, Bakhouche A. Bakhouche, Yasmine Tanner, Jun Wang, Emanuela Gadaleta, Claude Chelala, Kate M. Moore, John F. Marshall, Juliette Chupin, Peter Schmid, J. Louise Jones, Michelle Lockley, Pedro R. Cutillas, Richard P. Grose
Publikováno v: Cell Reports, Vol 22, Iss 9, Pp 2469-2481 (2018)
Summary: Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenan
Externí odkaz: https://doaj.org/article/7789669635aa4bc0b1737b37a1d0838a
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2
Akademický článek
C ∕ N ratio, stable isotope (δ13C, δ15N), and n-alkane patterns of brown mosses along hydrological gradients of low-centred polygons of the Siberian Arctic
Autor: R. Zibulski, F. Wesener, H. Wilkes, B. Plessen, L. A. Pestryakova, U. Herzschuh
Publikováno v: Biogeosciences, Vol 14, Iss 6, Pp 1617-1630 (2017)
Mosses are a major component of the arctic vegetation, particularly in wetlands. We present C ∕ N atomic ratio, δ13C and δ15N data of 400 brown-moss samples belonging to 10 species that were collected along hydrological gradients within polygonal
Externí odkaz: https://doaj.org/article/b081ce8812024e2980a1a2fdbcaa623e
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3
VeRification: an R Shiny application for laboratory method verification and validation
Autor: Edmund H. Wilkes
Publikováno v: Clinical Chemistry and Laboratory Medicine (CCLM).
Objectives According to international standards, clinical laboratories are required to verify the performance of assays prior to their implementation in routine practice. This typically involves the assessment of the assay’s imprecision and truenes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33c1efb6a315c403e4b3d4d49773e743
https://doi.org/10.1515/cclm-2023-0158
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4
A Practical Guide to Bayesian Statistics in Laboratory Medicine
Autor: Edmund H, Wilkes
Publikováno v: Clinical Chemistry. 68:893-905
Statistical analyses form a fundamental part of causal inference in the experimental sciences. The statistical paradigm most commonly taught to science students around the world is that of frequentism, with a particular emphasis on the null hypothesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f56394355683553a603471a3a5914c
https://doi.org/10.1093/clinchem/hvac049
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8
A Machine Learning Approach for the Automated Interpretation of Plasma Amino Acid Profiles
Autor: Erin Emmett, Gary Woodward, Luisa Beltran, Rachel S Carling, Edmund H Wilkes
Publikováno v: Clinical Chemistry. 66:1210-1218
BACKGROUND Plasma amino acid (PAA) profiles are used in routine clinical practice for the diagnosis and monitoring of inherited disorders of amino acid metabolism, organic acidemias, and urea cycle defects. Interpretation of PAA profiles is complex a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8e841e2000cb8b8e88eb0e457b43a1c
https://doi.org/10.1093/clinchem/hvaa134
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9
Akademický článek
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10
Akademický článek
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