Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins

Autor: Reinhard Mentele, Mohsen Khademi, Makbule Senel, Friedrich Lottspeich, Birgit Obermeier, Wolfgang Kristoferitsch, H. Wekerle, Hayrettin Tumani, Klaus Dornmair, Tomas Olsson, Jessica Bruder, Simone M. Brändle, Reinhard Hohlfeld

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmark of multiple sclerosis (MS), a disabling inflammatory disease of the central nervous system (CNS). OCBs are locally produced by clonally expanded antigen-experienced B cells and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc920c2a6b13aa446bf0a090b66baf9
https://doi.org/10.1073/pnas.1522730113

Context-dependent calcium signaling in encephalitogenic T cells – an in vivo two-photon imaging study

Autor: Stephanie Everts, Nikolaos I. Kyratsous, Ingo Bartholomäus, Guokun Zhang, Marija Pesic, Joanna M. Watt, Naoto Kawakami, Miriam Wörner, Ping Fang, Reinhard Hohlfeld, H. Wekerle, Marsilius Mues, Joachim W. Ellwart, Isabel J. Bauer, Barry V. L. Potter

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proc. Natl. Acad. Sci. U.S.A. 114, E6381-E6389 (2017)

In experimental autoimmune encephalitis (EAE), autoimmune T cells are activated in the periphery before they home to the CNS. On their way, the T cells pass through a series of different cellular milieus where they receive signals that instruct them

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b476f2bc673a22acb3cea6e6db102b
http://ora.ox.ac.uk/objects/uuid:

Antigen processing and presentation (PP-026)

Autor: P. A. Gleeson, P. van Endert, C. Hagemeier, M. S. Weber, D. Leclerc, S. Uda, Kajsa E. Prokopec, Y. Abe, M. Boulassel, T. Kim, C. K. Lee, M. Sakuramoto, A. Darabi, W. Pichler, M. Fleck, S. Urban, Y. Reiter, A. Homhuan, A. Respa, N. Itoh, C. Xu, S. Kim, C. C. Bernard, Christopher Linington, Y. C. Song, A. Halenius, M. C. I. Karlsson, T. Yoshikawa, J. Sathish, C. H. Leng, K. Sinik, M. van Lith, D. K. Y. Ang, N. Krug, E. Ross, J. Wagner, Y. Langelier, R. Lapointe, S. Liu, Y. Yang, Y. Sasaki, M. Bolduc, J. Kessler, X. Dai, K. Naumann, W. Schreiner, Y. Wu, F. Ebstein, S. Song, J. Falconer, S. Allen, J. Fu, T. Kanaseki, J. Zhang, M. Bourgeois-Daigneault, A. Kariyone, D. J. Naisbitt, N. Sato, C. E. Hioe, F. Dufour, A. Warnatsch, B. Reimann, W. H'ng, C. Carnrot, S. Xu, D. Bourges, J. Routy, M. Harndahl, M. Weimershaus, S. Matsunaga, Y. Louzoun, Y. Yu, P. M. Kloetzel, S. Barabas, J. Paschke, S. Buus, L. Zou, T. Vider-Shalit, H. Wekerle, K. Skjödt, S. Blais, T. Prod'homme, G. Roder, H. An, L. Hanafi, P. W. Chuang, J. C. Patarroyo, Q. Guo, S. A. Kaba, D. H. Fremont, H. Li, S. J. Liu, O. Kanagawa, H. Kamada, J. Castrejon, U. Omasits, S. Tochigi, M. Glickman, S. Wang, S. Lavergne, T. A. P. F. Pimental, S. Shaw, M. H. Huang, M. Singh, J. Ma, N. Ogawa, J. Fortin, Y. H. Lee, O. Mekler, K. Råsbo, C. Mittelholzer, T. Hirai, M. S. A. Albalushi, T. Imazawa, M. J. Rahman, H. Hengel, D. K. Cole, M. M. Epstein, E. Altman, Y. Tsutsumi, E. Krüger, Y. Bao, Y. Han, M. Park, B. Seliger, G. Patiño-López, K. Paulsson, L. Li, C. Schütz, O. D. Chuquimia, C. Thuring, C. Brando, K. Sawada, J. L. Maravillas-Montero, C. Schafer-Nielsen, C. Fernández, Y. Wan, P. G. Gillespie, H. Nabeshi, J. Han, A. Elsheikh, L. Deml, K. Takatsu, J. Li, K. H. Kim, Z. Guo, S. S. Zamvil, G. Liu, H. Cho, J. Taguchi, Y. Yoshioka, S. Mizukami, C. Qian, N. Molnarfi, L. Geironson, W. Ng, M. Keller, E. Kim, X. Xu, L. M. Hettihewa, M. Lee, T. Akase, N. Shastri, M. Ikutani, N. Nagachar, J. H. Robinson, M. E. McCoy, S. Tsunoda, P. Kloetzel, M. J. Shlomchik, H. Sohn, I. R. van Driel, B. K. Park, X. Cao, H. Udono, M. Laliberté, D. E. Lanar, M. Zhang, S. A. Im, L. Santos-Argumedo, B. Knapp, K. Hashimoto, M. Bouvier, K. Camfield Lind, D. Dasgupta, N. Gaudenzio, P. Burkhard, Y. Nagai, H. Kozono, A. H. Chou, K. Kim, Sandra Kleinau, S. K. Chiang, P. Chong, A. M. Benham, K. Nagano, T. Nakayama, A. Paschen, L. Saveanu, U. Seifert, C. Keller, J. Thibodeau

Publikováno v: International Immunology. 22:ii49-ii56

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e87a7b17349d192adee1ce8b9b88db3d
https://doi.org/10.1093/intimm/dxq113

Gut Microbiota in Multiple Sclerosis

Autor: H. Wekerle, R. Hohlfeld

Strong evidence supports an autoimmune pathogenesis of multiple sclerosis (MS), but the ultimate trigger has remained unknown. In addition to infective agents, recently the commensal gut flora has emerged as suspect. Studies of spontaneous experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47d7440c93e9baff2b182c5c87a65bbe
https://doi.org/10.1016/b978-0-12-801914-6.00009-x

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