Zobrazeno 1 - 10
of 665
pro vyhledávání: '"H, Tobias"'
Autor:
Benjamin G. Faber, Fiona Macrae, Mijin Jung, Benjamin E. Zucker, Rhona A. Beynon, Jonathan H. Tobias
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Recognising sex differences in disease prevalence can lead to clues as to its pathogenesis, for example the role of hormonal factors and related influences such as body composition, as well as forming the basis for new treatments. However, if differe
Externí odkaz:
https://doaj.org/article/bd66c5a2dd6f4b829f115632eb9e465d
Autor:
Jonathan H. Tobias, Katherine Samaras, Richard Ivell, Terry F. Davies, Åke Sjöholm, Iwan Day-Haynes, Jeff M.P. Holly
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/6028853acea34ef2b1048aa051da0b36
Autor:
Rhona A. Beynon, Fiona R. Saunders, Raja Ebsim, Monika Frysz, Benjamin G. Faber, Jennifer S. Gregory, Claudia Lindner, Aliya Sarmanova, Richard M. Aspden, Nicholas C. Harvey, Timothy Cootes, Jonathan H. Tobias
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100468- (2024)
Objective: We aimed to create an imaging biomarker for knee shape using knee dual-energy x-ray absorptiometry (DXA) scans and investigate its potential association with subsequent total knee replacement (TKR), independently of radiographic features o
Externí odkaz:
https://doaj.org/article/c4c3ff415ab44f73aa0ce2a06285f078
Autor:
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bønnelykke, Andre G. Uitterlinden, Unnur Styrkársdóttir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analy
Externí odkaz:
https://doaj.org/article/48a29b7a20594248bc9b5e7eb32dd872
Autor:
Giacomina Brunetti, Jonathan H. Tobias
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/8c00f6734d6e4dacbc73878951b6fec7
Autor:
Benjamin G. Faber, Monika Frysz, Cindy G. Boer, Daniel S. Evans, Raja Ebsim, Kaitlyn A. Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R. Saunders, Claudia Lindner, Jennifer S. Gregory, Richard M. Aspden, Nancy E. Lane, Nicholas C. Harvey, David M. Evans, Eleftheria Zeggini, George Davey Smith, Timothy Cootes, Joyce Van Meurs, John P. Kemp, Jonathan H. Tobias
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104759- (2023)
Summary: Background: Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic determinants of mJSW and (ii) identify which mJ
Externí odkaz:
https://doaj.org/article/e65b32b807094d3195f523dc966a7bd4
Autor:
B. E. Zucker, R. Ebsim, C. Lindner, S. Hardcastle, T. Cootes, J. H. Tobias, M. R. Whitehouse, C. L. Gregson, B. G. Faber, A. E. Hartley
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background High bone mass (HBM, BMD Z-score ≥ + 3.2) and cam morphology (bulging of lateral femoral head) are associated with greater odds of prevalent radiographic hip osteoarthritis (rHOA). As cam morphology is itself a manifestation of
Externí odkaz:
https://doaj.org/article/5b3418039c4846b9a3d29b85f273fba6
Autor:
Sofia Movérare-Skrtic, Jakob Voelkl, Karin H. Nilsson, Maria Nethander, Trang Thi Doan Luong, Ioana Alesutan, Lei Li, Jianyao Wu, Karin Horkeby, Marie K. Lagerquist, Antti Koskela, Juha Tuukkanen, Jon H. Tobias, Ulf H. Lerner, Petra Henning, Claes Ohlsson
Publikováno v:
EBioMedicine, Vol 91, Iss , Pp 104546- (2023)
Summary: Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene
Externí odkaz:
https://doaj.org/article/dcd0ba5afbb847689c3ed1feff4c91de
Autor:
Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen, Pedro P. C. Souza, Jan Tuckermann, Mattias Lorentzon, Linda Engström Ruud, Terho Lehtimäki, Jon H. Tobias, Sirui Zhou, Ulf H. Lerner, J. Brent Richards, Sofia Movérare-Skrtic, Claes Ohlsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone stre
Externí odkaz:
https://doaj.org/article/bb0475854da041a2990d5eeb48bf5cee
Autor:
Jonathan H. Tobias, Giacomina Brunetti
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1f062b7e35ca4f89ba8ccf1aa1655fe3