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Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization

Autor: R D, Schwarz, M J, Callahan, L L, Coughenour, M R, Dickerson, J J, Kinsora, W J, Lipinski, C A, Raby, C J, Spencer, H, Tecle

Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(2)

Milameline (E-1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxaldehyde, O-methyloxime monohydrochloride, CI-979, PD129409, RU35926) was characterized in vitro and evaluated for effects on central and peripheral cholinergic activity in rats and rhesus mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00ccd35c8d9f022cb3f8418b8cbae48a
https://pubmed.ncbi.nlm.nih.gov/10525104

Structural Insights on the Role of Halogen Bonding in Protein MEK Kinase-Inhibitor Complexes.

Autor: Milesi P; Laboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via L. Mancinelli 7, 20131, Milano, Italy.; Laboratory of Innovative approaches for tissue engineering and drug delivery, Joint Research Platform 'ONCO-TECH LAB - Modeling and Applications for Human Health', Politecnico di Milano - IEO 'European Institute of Oncology', IRCCS, Via Adamello 16, 20139, Milano, Italy., Baldelli Bombelli F; Laboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via L. Mancinelli 7, 20131, Milano, Italy.; Laboratory of Innovative approaches for tissue engineering and drug delivery, Joint Research Platform 'ONCO-TECH LAB - Modeling and Applications for Human Health', Politecnico di Milano - IEO 'European Institute of Oncology', IRCCS, Via Adamello 16, 20139, Milano, Italy., Lanfrancone L; Laboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via L. Mancinelli 7, 20131, Milano, Italy.; Laboratory of Innovative approaches for tissue engineering and drug delivery, Joint Research Platform 'ONCO-TECH LAB - Modeling and Applications for Human Health', Politecnico di Milano - IEO 'European Institute of Oncology', IRCCS, Via Adamello 16, 20139, Milano, Italy., Gomila RM; Department of Chemistry, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, 07122, Palma de Mallorca (Baleares), Spain., Frontera A; Department of Chemistry, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, 07122, Palma de Mallorca (Baleares), Spain., Metrangolo P; Laboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via L. Mancinelli 7, 20131, Milano, Italy.; Laboratory of Innovative approaches for tissue engineering and drug delivery, Joint Research Platform 'ONCO-TECH LAB - Modeling and Applications for Human Health', Politecnico di Milano - IEO 'European Institute of Oncology', IRCCS, Via Adamello 16, 20139, Milano, Italy., Terraneo G; Laboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Via L. Mancinelli 7, 20131, Milano, Italy.

Publikováno v: Chemistry, an Asian journal [Chem Asian J] 2024 Apr 02; Vol. 19 (7), pp. e202301033. Date of Electronic Publication: 2024 Mar 19.

Three Component One-Pot Synthesis of Novel 8-Benzyloxy-5-{2-[N′-(1,3-Diphenyl-1H-Pyrazol-4-Ylmethylene)-Hydrazino]-Thiazol-4-yl}-3,4-Dihydro-1H-Quinolin-2-Ones.

Autor: Choudhare, Tukaram S.¹ (AUTHOR), Wagare, Devendra S.² (AUTHOR), Jagrut, Vasant B.³ (AUTHOR), Netankar, Prashant D.¹ (AUTHOR)

Publikováno v: Polycyclic Aromatic Compounds. 2023, Vol. 43 Issue 3, p2672-2679. 8p.

Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat.

Autor: Corner TP; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.; Present Address: Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, 06511, United States of America., Salah E; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Tumber A; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Kaur S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Nakashima Y; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan., Allen MD; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Schnaubelt LI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Fiorini G; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Brewitz L; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Dec 16; Vol. 19 (24), pp. e202400504. Date of Electronic Publication: 2024 Nov 08.