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Autor:
Ilse vom Hofe, Bruno H. Stricker, Meike W. Vernooij, M. Kamran Ikram, M. Arfan Ikram, Frank J. Wolters
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Benzodiazepine use is common, particularly in older adults. Benzodiazepines have well-established acute adverse effects on cognition, but long-term effects on neurodegeneration and dementia risk remain uncertain. Methods We includ
Externí odkaz:
https://doaj.org/article/3e425f59612e433990f8ac8341df49a8
Autor:
Anna Vanoverschelde, Samer R. Khan, Virgil A.S.H. Dalm, Layal Chaker, Guy Brusselle, Bruno H. Stricker, Lies Lahousse
Publikováno v:
Clinical Immunology Communications, Vol 4, Iss , Pp 23-29 (2023)
ABSTRACT: Objectives: Elderly become more susceptible to lower respiratory tract infections, resulting in antibiotic prescriptions. Immunoglobulins (Ig) play an important role in host defense and protection against infections. Therefore, we aimed to
Externí odkaz:
https://doaj.org/article/0b0dfcf52336458c9d92957b5bef0473
Autor:
Christopher M Reid, Rachael Moorin, Sallie-Anne Pearson, Max K Bulsara, David B Preen, Gita Mishra, David Youens, Jeffery David Hughes, Ninh Thi Ha, Bruno H Stricker, Rikje Ruiter, Cameron Wright, Chau Ho, Walter P Abhayaratna, Christobel M Saunders, Frank J A van Rooij
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Introduction Calcium channel blockers (CCB), a commonly prescribed antihypertensive (AHT) medicine, may be associated with increased risk of breast cancer. The proposed study aims to examine whether long-term CCB use is associated with the developmen
Externí odkaz:
https://doaj.org/article/3d0d93f9093c4d2896430d9034b560b1
Autor:
Shiva Najjary, Johan M. Kros, Bruno H. Stricker, Rikje Ruiter, Yu Shuai, Robert Kraaij, Kristel Van Steen, Peter van derSpek, Casper H. J. Van Eijck, M. Arfan Ikram, Shahzad Ahmad
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract The immune response–gut microbiota interaction is implicated in various human diseases, including cancer. Identifying the link between the gut microbiota and systemic inflammatory markers and their association with cancer will be important
Externí odkaz:
https://doaj.org/article/5c6d3b511d7247668c577ceb0cb7ec86
Autor:
Mulugeta Russom, Daniel Y. B. Jeannetot, Araia Berhane, Henok G. Woldu, Bruno H. Stricker, Katia M. C. Verhamme
Publikováno v:
Drugs - Real World Outcomes, Vol 10, Iss 3, Pp 383-394 (2023)
Abstract Introduction A 6-month course of isoniazid, 300 mg daily, was programmatically introduced in Eritrea in 2014 as tuberculosis preventive therapy in people living with human immunodeficiency virus (PLHIV). The rollout of isoniazid preventive t
Externí odkaz:
https://doaj.org/article/9c616b1b01124212abd63f6b409409e9
Autor:
William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, Linda Repetto, Jie Yao, Aaron Isaacs, Andrew R. Harper, Julia Ramirez, Sophie Garnier, Stefan van Duijvenboden, Antoine R. Baldassari, Maria Pina Concas, ThuyVy Duong, Luisa Foco, Jonas L. Isaksen, Hao Mei, Raymond Noordam, Casia Nursyifa, Anne Richmond, Meddly L. Santolalla, Colleen M. Sitlani, Negin Soroush, Sébastien Thériault, Stella Trompet, Stefanie Aeschbacher, Fariba Ahmadizar, Alvaro Alonso, Jennifer A. Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Antonio De Luca, Jean-François Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Christopher Grace, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Rebecca D. Jackson, Jan A. Kors, Maria Fernanda Lima-Costa, Allan Linneberg, Peter W. Macfarlane, Alanna C. Morrison, Pau Navarro, David J. Porteous, Peter P. Pramstaller, Alexander P. Reiner, Lorenz Risch, Ulrich Schotten, Xia Shen, Gianfranco Sinagra, Elsayed Z. Soliman, Monika Stoll, Eduardo Tarazona-Santos, Andrew Tinker, Katerina Trajanoska, Eric Villard, Helen R. Warren, Eric A. Whitsel, Kerri L. Wiggins, Dan E. Arking, Christy L. Avery, David Conen, Giorgia Girotto, Niels Grarup, Caroline Hayward, J.Wouter Jukema, Dennis O. Mook-Kanamori, Morten Salling Olesen, Sandosh Padmanabhan, Bruce M. Psaty, Cristian Pattaro, Antonio Luiz P. Ribeiro, Jerome I. Rotter, Bruno H. Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James G. Wilson, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry J. Lin, James F. Wilson, Jørgen K. Kanters, Nona Sotoodehnia, Borbala Mifsud, Pier D. Lambiase, Larisa G. Tereshchenko, Patricia B. Munroe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.
Externí odkaz:
https://doaj.org/article/dafca92a55c441c48a99162ccb2f3205
Autor:
Elizabeth Benz, Lies Lahousse, Johnmary T. Arinze, Sara Wijnant, Maria de Ridder, Fernando Rivadeneira, Guy Brusselle, Bruno H. Stricker
Publikováno v:
ERJ Open Research, Vol 9, Iss 5 (2023)
Background Sarcopenia is characterised by two major phenotypic components: low handgrip strength (HGS) and appendicular skeletal muscle index (ASMI). Oral corticosteroid (OCS) use is an important medication for acute respiratory exacerbations in pati
Externí odkaz:
https://doaj.org/article/e21ec72434b24ba3be98267edd0018cd
Autor:
Bob A Hersbach, David S Fischer, Giacomo Masserdotti, Deeksha, Karolina Mojžišová, Thomas Waltzhöni, Diego Rodriguez‐Terrones, Matthias Heinig, Fabian J Theis, Magdalena Götz, Stefan H Stricker
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-23 (2022)
Abstract Despite the therapeutic promise of direct reprogramming, basic principles concerning fate erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these fundamental questions, we established a single‐cell pro
Externí odkaz:
https://doaj.org/article/7ee96a824f2445ee879799d35c3bf713
Autor:
Zuolin Lu, Martijn J. Tilly, Elif Aribas, Daniel Bos, Sven Geurts, Bruno H. Stricker, Robert de Knegt, M. Arfan Ikram, Natasja M. S. de Groot, Trudy Voortman, Maryam Kavousi
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Background Obesity is a well-established risk factor for atrial fibrillation (AF). Whether body fat depots differentially associate with AF development remains unknown. Methods In the prospective population-based Rotterdam Study, body compos
Externí odkaz:
https://doaj.org/article/82164a924da34f61808b6fe62fd713bf