Zobrazeno 1 - 10
of 1 792
pro vyhledávání: '"H, Sharp"'
Autor:
Stephanie A. Schubert, Dina Ruano, Sebastien M. Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M. Pinto, Mar Rodríguez-Girondo, Daniela Q. C. M. Barge-Schaapveld, Maartje Nielsen, Bernadette P. M. van Nesselrooij, Arjen R. Mensenkamp, Monique E. van Leerdam, Thomas H. Sharp, Hans Morreau, Jean-Christophe Bourdon, Noel F. C. C. de Miranda, Tom van Wezel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ, are not fully considered in the molecular diagnosis of Li-Fr
Externí odkaz:
https://doaj.org/article/56ab10ecaf2a481fbf606ffec4b57f89
Autor:
L. Fisher, A. Davey, G. Wong, S. Morgan-Trimmer, L. M. Howard, H. Sharp, K. H. Atmore, J. Brook, G. Collins, J. Domoney, E. Makinde, C. McCree, Heather A O’Mahen
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In recognition of the burden of Perinatal Mental Health problems, NHS England invested £365 million to transform women’s access to mental health care, including investment in Community Perinatal Mental Health Services. This stu
Externí odkaz:
https://doaj.org/article/9bbca3bf5a2245c8af81d011d3b81c34
Autor:
Alice R. Phillips, Sarah L. Halligan, Megan Bailey, Marianne Skogbrott Birkeland, Iris Lavi, Richard Meiser-Stedman, Hannah Oram, Susan Robinson, Tamsin H. Sharp, Rachel M. Hiller
Publikováno v:
European Journal of Psychotraumatology, Vol 15, Iss 1 (2024)
Objective: Young people with post-traumatic stress disorder experience difficulties in social and interpersonal domains. We examined whether the best-evidenced treatments of PTSD for children and young people (Trauma-focussed Cognitive Behavioural Th
Externí odkaz:
https://doaj.org/article/76cf5c547f3c47d68ce886546959911b
Autor:
Natalia E. Fares-Otero, Tamsin H. Sharp, Stefanie R. Balle, Sarah M. Quaatz, Eduard Vieta, Fredrik Åhs, Antje-Kathrin Allgaier, Adrián Arévalo, Rahel Bachem, Habte Belete, Tilahun Belete Mossie, Azi Berzengi, Necip Capraz, Deniz Ceylan, Daniel Dukes, Aziz Essadek, Naved Iqbal, Laura Jobson, Einat Levy-Gigi, Antonia Lüönd, Chantal Martin-Soelch, Tanja Michael, Misari Oe, Miranda Olff, Helena Örnkloo, Krithika Prakash, Muniarajan Ramakrishnan, Vijaya Raghavan, Vedat Şar, Soraya Seedat, Georgina Spies, Vandhana SusilKumar, Dany Laure Wadji, Rachel Wamser-Nanney, Shilat Haim-Nachum, Ulrich Schnyder, Marie R. Sopp, Monique C. Pfaltz, Sarah L. Halligan
Publikováno v:
European Journal of Psychotraumatology, Vol 15, Iss 1 (2024)
Background: Perceived social support is an established predictor of post-traumatic stress disorder (PTSD) after exposure to a traumatic event. Gender is an important factor that could differentiate responses to social support, yet this has been littl
Externí odkaz:
https://doaj.org/article/5a7456b4d03b4df8945746ee8a30ca55
Autor:
Mark Tomlinson, Cathy Creswell, Xanthe Hunt, Soraya Seedat, Sarah L Halligan, Richard Meiser-Stedman, Pasco Fearon, Catherine Hamilton-Giachritsis, Jackie Stewart, Rachel Hiller, Stefani Du Toit, Tamsin H Sharp, Yeukai Chideya, Alessandra Giuliani
Publikováno v:
BMJ Open, Vol 14, Iss 7 (2024)
Introduction Children exposed to trauma are vulnerable to developing post-traumatic stress disorder (PTSD) and other adverse mental health outcomes. In low-and middle-income countries (LMICs), children are at increased risk of exposure to severe trau
Externí odkaz:
https://doaj.org/article/d419ba7f1e67415c95f163947c736979
Autor:
Roy Pattipeiluhu, Ye Zeng, Marco M.R.M. Hendrix, Ilja K. Voets, Alexander Kros, Thomas H. Sharp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly, as exemplified by the re
Externí odkaz:
https://doaj.org/article/0ef712d144ab4333b226a1ffb3de110e
Autor:
Haiyu Wang, Fleur S. van de Bovenkamp, Douwe J. Dijkstra, Leoni Abendstein, Nicole V. Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A. Gelderman, Timon Damelang, Gestur Vidarsson, Anna M. Blom, Elena Domínguez-Vega, Paul W. H. I. Parren, Thomas H. Sharp, Leendert A. Trouw
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, u
Externí odkaz:
https://doaj.org/article/66693f5931e04cbdb02cb3b635c4eb80
Autor:
Leoni Abendstein, Douwe J. Dijkstra, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Leendert A. Trouw, Paul J. Hensbergen, Thomas H. Sharp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented as an immunothe
Externí odkaz:
https://doaj.org/article/fcdc499f722c4bd9aa23f3e4ee0d4314
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cryogenic transmission electron microscopy (cryo-TEM) and super-resolution fluorescence microscopy are two popular and ever improving methods for high-resolution imaging of biological samples. In recent years, the combination of these two te
Externí odkaz:
https://doaj.org/article/d959289fcf2044e8bf67ea5c4e2472e9
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance. A numbe
Externí odkaz:
https://doaj.org/article/a62734877f434c9ab37f367a1cf3ab19