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Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals

Autor: E J, Mroszczak, D, Jung, J, Yee, L, Bynum, H, Sevelius, I, Massey

Publikováno v: Pharmacotherapy. 10(6 ( Pt 2))

In humans, ketorolac is completely bioavailable and its kinetics are linear. It is absorbed rapidly (half-life for absorption 3.8 min) after oral (fasting) and intramuscular administration; food delays but does not reduce its absorption. The drug is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b73cbcaa1051b91fbfbc0b7e3b7069b
https://pubmed.ncbi.nlm.nih.gov/2082311

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Antisecretory and serum gastrin lowering effect of enprostil in patients with duodenal ulcer disease

Autor: H. Sevelius, Keith Walker, V. Mahachai, Alan B. R. Thomson

Publikováno v: Gastroenterology. 89:555-561

This study was designed to compare the effects of enprostil, a synthetic dehydro-prostaglandin E2, on 24-h intragastric pH and serum gastrin profile in patients with duodenal ulcer disease. The dosing regimen included 3 enprostil groups: 35 microgram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cfa442c47765ee4cc0d2873957e3d1
https://doi.org/10.1016/0016-5085(85)90451-2

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Bioavailability of naproxen sodium and its relationship to clinical analgesic effects

Autor: R Runkel, SS Bloomfield, Eugene Segre, H Sevelius

1 In the first of a series of trials with naproxen sodium it was shown that patients achieved significantly earlier and higher plasma levels of naproxen when naproxen sodium was administered. 2 In a second study comparing naproxen with naproxen sodiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d5d829011f4c3084c5dafb2239fd7a
https://europepmc.org/articles/PMC1430062/

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Letter: Effects of antacids on naproxen absorption

Autor: E J, Segre, H, Sevelius, J, Varady

Publikováno v: The New England journal of medicine. 291(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f2e68db1e7a75f3d1c76c76be8067be
https://pubmed.ncbi.nlm.nih.gov/4852768

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Pharmacokinetics of ketorolac and p-hydroxyketorolac following oral and intramuscular administration of ketorolac tromethamine

Autor: D, Jung, E J, Mroszczak, A, Wu, T L, Ling, H, Sevelius, L, Bynum

Publikováno v: Pharmaceutical research. 6(1)

Ketorolac tromethamine (KT), a potent analgesic with cyclooxygenase inhibitory activity, was administered in an open, randomized, single-dose study of Latin-square design to 12 healthy male volunteers. Doses of 30 mg oral (po) and 30, 60, and 90 mg i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a2e94867d7c1b27789093521882fcdd
https://pubmed.ncbi.nlm.nih.gov/2717521

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Protection against aspirin-induced antral and duodenal damage with enprostil. A double-blind endoscopic study

Autor: M M, Cohen, D R, McCready, L, Clark, H, Sevelius

Publikováno v: Gastroenterology. 88(1 Pt 2)

Prostaglandins protect against aspirin-induced damage to the gastrointestinal tract. This study tested the ability of enprostil, a synthetic analog of prostaglandin E2, given concurrently to prevent gastroduodenal injury. Twenty-four healthy subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e33a8d3c8d082063b55d68b7e45ecfbf
https://pubmed.ncbi.nlm.nih.gov/3917264

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The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt

Autor: W H, Rooks, P J, Maloney, L D, Shott, M E, Schuler, H, Sevelius, A M, Strosberg, L, Tanenbaum, A J, Tomolonis, M B, Wallach, D, Waterbury

Publikováno v: Drugs under experimental and clinical research. 11(8)

Ketorolac tromethamine[(+/-)-5(benzoyl)-2,3-dihydro-1N-pyrrolizine-1-carboxylic acid tris hydroxymethylaminomethane salt] is a highly potent member of a new class of compounds having analgesic and anti-inflammatory activity. When given orally in test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::151d93be1b88c06aca6fb643c4576a98
https://pubmed.ncbi.nlm.nih.gov/3879752

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