Výsledky vyhledávání - "H, Schlechte"

TP53 gene mutations in prostate cancer progression

Autor: Thorsten H, Ecke, Horst H, Schlechte, Katrin, Schiemenz, Markus D, Sachs, Severin V, Lenk, Birgit D, Rudolph, Stefan A, Loening

Publikováno v: Anticancer research. 30(5)

We assessed the predictive value of TP53 mutations and prostate-specific antigen (PSA) for tumor progression in prostate cancer (PCa) patients.Ninety tumor tissue samples of patients with PCa from radical prostatectomy were used. Tumor progression wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2012e28bd3bdd7013f091cf08c0acd3
https://pubmed.ncbi.nlm.nih.gov/20592345

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TP53 gene mutations as an independent marker for urinary bladder cancer progression

Autor: Thorsten H, Ecke, Markus D, Sachs, Severin V, Lenk, Stefan A, Loening, Horst H, Schlechte

Publikováno v: International journal of molecular medicine. 21(5)

This study evaluates the influence of the TP53 genetic status on tumour recurrence and progression with a highly effective electrophoretic technique. DNA from tissue of 75 non-invasive urinary bladder cancers was PCR amplified in the TP53 exons 5-8 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7c2387c4b6939ef5390d982ef6f2b9e
https://pubmed.ncbi.nlm.nih.gov/18425359

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TP53 mutation in prostate needle biopsies--comparison with patients follow-up

Autor: Thorsten H, Ecke, Horst H, Schlechte, Anne, Hübsch, Severin V, Lenk, Katrin, Schiemenz, Birgit D, Rudolph, Kurt, Miller

Publikováno v: Anticancer research. 27(6B)

The predictive value of TP53 mutations and prostate-specific antigen (PSA) was assessed in prostate needle biopsies of samples without signs of malignancy for later affliction by prostate cancer (PCa). Comparison of mutation frequency and PSA level i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8674caeba9b1f5aeadaa1070c4e3900
https://pubmed.ncbi.nlm.nih.gov/18225585

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Body mass index (BMI) and mutations of tumor suppressor gene p53 (TP53) in patients with urinary bladder cancer

Autor: Sven Gunia, Severin V. Lenk, Thorsten H. Ecke, Stefan A. Loening, Horst H. Schlechte

Publikováno v: Urologic oncology. 26(5)

Objective Obesity is estimated to account for up to 20% of all cancer deaths. Mutations of TP53 are frequently correlated with tumor development and progression. We evaluated the effect of body mass index (BMI) and mutation status of tumor suppressor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a566cf81ac50c0a81c174046f0ce091
https://pubmed.ncbi.nlm.nih.gov/18367114

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Tissue polypeptide antigen (TPA) in comparison with mutations of tumour suppressor gene P53 (TP53) in patients with bladder cancer

Autor: Thorsten H, Ecke, Severin V, Lenk, Horst H, Schlechte, Stefan A, Loening

Publikováno v: Anticancer research. 23(2A)

Tissue polypeptide antigen (TPA) is a circulating complex of polypeptide fragments from cytokeratins 8, 18 and 19. It is a tumour-related protein. TPA is an indicator of higher cell proliferation. One function of TP53 is the suppression of apoptosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67c943a9639bd10511f495282873fefe
https://pubmed.ncbi.nlm.nih.gov/12820330

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[Detection of TP53-mutations in brush biopsies from oral leukoplakias]

Autor: C, Scheifele, H, Schlechte, G, Bethke, P A, Reichart

Publikováno v: Mund-, Kiefer- und Gesichtschirurgie : MKG. 6(6)

The aim of this study was to determine the prevalence of mutations of the tumour suppressor gene TP53 in oral leukoplakias.Brush biopsy specimens of 43 oral leukoplakias, 26 oral squamous cell carcinomas (OSCC) for reference, and the oral mucosa of 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::414bdaa5e9ad3034cf304d830851b59f
https://pubmed.ncbi.nlm.nih.gov/12447653

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Progression in transitional cell carcinoma of the urinary bladder--analysis of Tp53 gene mutations by temperature gradients and sequence in tumor tissues and in cellular urine sediments

Autor: H H, Schlechte, M D, Sachs, S V, Lenk, S, Brenner, B D, Rudolph, S A, Loening

Publikováno v: Cancer detection and prevention. 24(1)

The relationship between expression of p53 protein in bladder cancer and tumor progression is known. In this paper, we attempt to study this phenomenon by molecular-genetic techniques. One hundred thirty-seven bladder tumor tissues were obtained from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ffb7afe3f721b67d50045c8bd957b7fe
https://pubmed.ncbi.nlm.nih.gov/10757120

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[p53 mutations and HPV infections in squamous epithelial carcinomas of the head-neck region. Long-term follow-up]

Autor: S, Riethdorf, R E, Friedrich, J, Sühwold, C, Ostwald, M, Barten, P, Gogacz, K K, Gundlach, H, Schlechte, J, Becker, T, Bregenzer, L, Riethdorf, T, Löning

Publikováno v: Mund-, Kiefer- und Gesichtschirurgie : MKG. 2(1)

Mutations of the p53 gene are the most commonly observed genetic alterations in malignant tumors and are often associated with a loss of the tumor suppressor function of the p53 protein. We have analyzed specimens of head and neck squamous cell carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f4e92cca24c1704b3e521c53cd5a69b
https://pubmed.ncbi.nlm.nih.gov/9522570

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p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long-term follow-up study

Autor: M. Barten, T. Löning, Karsten K.H. Gundlach, L. Riethdorf, J. Becker, Reinhard E Friedrich, H. Schlechte, S. Riethdorf, T. Bregenzer, Christiane Ostwald, P. Gogacz

Publikováno v: Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 26(7)

We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d7bddd10ffda679dafca432dec0d81
https://pubmed.ncbi.nlm.nih.gov/9250931

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