Zobrazeno 1 - 10
of 342
pro vyhledávání: '"H, Reggio"'
Autor:
Asher L. Brandt, Sumanta Garai, Ayat Zagzoog, Dow P. Hurst, Lesley A. Stevenson, Roger G. Pertwee, Gregory H. Imler, Patricia H. Reggio, Ganesh A. Thakur, Robert B. Laprairie
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune disorders. To date, a few studies have evaluated the structure-activity relationship (SAR) for CB1R positive allo
Externí odkaz:
https://doaj.org/article/1b3a23ef982f4f8891ff2eb902358d26
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical CBRs CB1 and CB2 are highly implicated in these pathological events. However, selective targeting
Externí odkaz:
https://doaj.org/article/ac74d42050f64b19959deb4153459339
Autor:
Chanté Muller, Patricia H. Reggio
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Cannabinoids have been long studied for their therapeutic properties, particularly for their use in the treatment of pain. As new therapies are sought after to treat conditions of chronic pain, so is a better understanding of the ligands and their ta
Externí odkaz:
https://doaj.org/article/68282952314842c3a4a5d2eafc3a24a5
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The transient receptor potential subfamily vanilloid type 1 ion channel (TRPV1), located in the peripheral nervous system has been implicated in the perception of pain and possesses the ability to be modulated by various cannabinoid ligands. Because
Externí odkaz:
https://doaj.org/article/98eb59aeafc64eaca56fd1c630026aed
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2019)
Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of chemical and physical stimuli. These channels modulate ion entry, mediating a variety of neural signaling processes implicated
Externí odkaz:
https://doaj.org/article/9ae20e2588b146d89efc422cf8cb743b
Autor:
Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P. Hurst, Sommayah S. Sayed, Katsuya L. Colón, María Gómez-Cañas, Javier Fernández-Ruiz, Mitchell P. Croatt, Patricia H. Reggio, Mary E. Abood, Nadine Jagerovic
GPR55 is an orphan G-protein coupled receptor involved in various pathophysiological conditions. However, there are only a few noncannabinoid GPR55 ligands reported so far. The lack of potent and selective GPR55 ligands precludes a deep exploration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae463e4b82c805a8a62fc3966e760b0e
http://hdl.handle.net/10261/309060
http://hdl.handle.net/10261/309060
Autor:
Israa H. Isawi, Paula Morales, Noori Sotudeh, Dow P. Hurst, Diane L. Lynch, Patricia H. Reggio
Publikováno v:
Molecules, Vol 25, Iss 3, p 725 (2020)
GPR6 is an orphan G protein-coupled receptor that has been associated with the cannabinoid family because of its recognition of a sub-set of cannabinoid ligands. The high abundance of GPR6 in the central nervous system, along with high constitutive a
Externí odkaz:
https://doaj.org/article/b29654b473574beeb8a32aa15d7b44d4
Publikováno v:
Journal of Chemical Information and Modeling. 61:5742-5746
The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a746244f61434f5dc3e79b95cd06d16
https://doi.org/10.1021/acs.jcim.1c00893
https://doi.org/10.1021/acs.jcim.1c00893
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its ben
Externí odkaz:
https://doaj.org/article/a99fa04a986b4bacaeef95d0f24ddaeb
Autor:
Luciana M. Leo, Rufaida Al-Zoubi, Dow P. Hurst, Anna P. Stephan, Pingwei Zhao, Douglas G. Tilley, Elke Miess, Stefan Schulz, Mary E. Abood, Patricia H. Reggio
Publikováno v:
Cannabis and cannabinoid research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801b5c55b14222086b07ec6b63a1b618
https://pubmed.ncbi.nlm.nih.gov/35792570
https://pubmed.ncbi.nlm.nih.gov/35792570