Zobrazeno 1 - 10
of 158
pro vyhledávání: '"H, RADKE"'
Autor:
Judith Hüttemeister, Franziska Rudolph, Michael H Radke, Claudia Fink, Dhana Friedrich, Stephan Preibisch, Martin Falcke, Eva Wagner, Stephan E Lehnart, Michael Gotthardt
Publikováno v:
eLife, Vol 13 (2024)
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly have started to emerge with the poss
Externí odkaz:
https://doaj.org/article/ae88f7936ce54f1398b374a04ef05988
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Autor:
Markus Grosch, Laura Schraft, Adrian Chan, Leonie Küchenhoff, Kleopatra Rapti, Anne-Maud Ferreira, Julia Kornienko, Shengdi Li, Michael H. Radke, Chiara Krämer, Sandra Clauder-Münster, Emerald Perlas, Johannes Backs, Michael Gotthardt, Christoph Dieterich, Maarten M. G. van den Hoogenhof, Dirk Grimm, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to CRISPR-based gene therapy. However
Externí odkaz:
https://doaj.org/article/287d1894c5f548b689b58cdf403063c5
Autor:
Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
Externí odkaz:
https://doaj.org/article/8f93ea653e124b8e83b6b456aadd7c7e
Autor:
Kollar, M., Eckstein, M., Byczuk, K., Blümer, N., van Dongen, P., de Cuba, M. H. Radke, Metzner, W., Tanaskovic, D., Dobrosavljevic, V., Kotliar, G., Vollhardt, D.
Publikováno v:
Ann. Phys. (Leipzig) 14, 642 (2005)
We calculate the local Green function for a quantum-mechanical particle with hopping between nearest and next-nearest neighbors on the Bethe lattice, where the on-site energies may alternate on sublattices. For infinite connectivity the renormalized
Externí odkaz:
http://arxiv.org/abs/cond-mat/0504637
Autor:
Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198492 (2018)
Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in d
Externí odkaz:
https://doaj.org/article/441cee579c294cd1b25a4e8286c8ed79
Autor:
Victor Badillo-Lisakowski, Jacobo Lopez Carballo, Thiago Britto-Borges, Judith Hüttemeister, Michael H. Radke, Martin Liss, Pragati Parakkat, René Jüttner, Arne Hansen, Christoph Dieterich, Dieter A. Kubli, Michael Gotthardt, Adam E. Mullick
Publikováno v:
Science Translational Medicine. 13
Heart failure with preserved ejection fraction (HFpEF) is prevalent and deadly, but so far, there is no targeted therapy. A main contributor to the disease is impaired ventricular filling, which we improved with antisense oligonucleotides (ASOs) targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79038fdf1629c02157e2aac0371517d2
https://doi.org/10.1126/scitranslmed.abe8952
https://doi.org/10.1126/scitranslmed.abe8952
Autor:
Christopher Polack, Michael Gotthardt, Henk Granzier, Michael H. Radke, Claudia Fink, Mei Methawasin
Publikováno v:
Circulation. 139:1813-1827
Background: Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434bfb2d36cc396d5ddf99124d3dddbf
https://doi.org/10.1161/circulationaha.118.037588
https://doi.org/10.1161/circulationaha.118.037588
Autor:
M. Gesell-Salazar, Nora Bergmann, Charles T. Robbins, D. A. Mugahid, Wei Chen, Andreas Ofenbauer, Stefan Kempa, L. Nelson, Baris Tursun, Leif Steil, Yongbo Wang, Uwe Völker, András Balogh, T. G. Sengul, X. You, Michael Gotthardt, Michael H. Radke
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72d2acc37716b746c50dcce1a619d72
https://doi.org/10.1038/s41598-020-61340-4
https://doi.org/10.1038/s41598-020-61340-4
Autor:
Victor Badillo Lisakowski, Michael H. Radke, Thiago Britto-Borges, Dieter Kubli, René Jüttner, Pragati Parakkat, Jacobo López Carballo, Judith Hüttemeister, Martin Liss, Arne Hansen, Christoph Dieterich, Adam Mullick, Michael Gotthardt
Publikováno v:
Biophysical Journal. 121:396a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7faa0ea77785595560dc107953823f7c
https://doi.org/10.1016/j.bpj.2021.11.779
https://doi.org/10.1016/j.bpj.2021.11.779
Autor:
D. A. Mugahid, T. G. Sengul, X. You, Y. Wang, L. Steil, N. Bergmann, M. H. Radke, A. Ofenbauer, M. Gesell-Salazar, A. Balogh, S. Kempa, B. Tursun, C. T. Robbins, U. Völker, W. Chen, L. Nelson, M. Gotthardt
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Muscle atrophy is a physiological response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomenon. Unlike other mammals, they efficiently reabsorb amino acids from urine, periodically activate muscle contraction, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::71acc7826626e6f15772dcfcd27b62c6
http://europepmc.org/articles/PMC6934745
http://europepmc.org/articles/PMC6934745