Zobrazeno 1 - 10
of 87
pro vyhledávání: '"H, Pruul"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:3892-3904
Enterococcus faecium clinical isolates A902 and BM4538, which were resistant to relatively high levels of vancomycin (128 and 64 μg/ml, respectively) and to low levels of teicoplanin (4 μg/ml), and Enterococcus faecalis clinical isolates BM4539 and
Autor:
P J McDonald, H. Pruul
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:10-16
The interaction of azithromycin with normal human serum was examined in relation to serum protein binding, MIC, and kinetics of killing of bacteria. While the binding of azithromycin to serum proteins is low (8.5% at a concentration of 0.01 mM in 95%
Autor:
P. J. McDonald, H. Pruul
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 10:828-833
Azithromycin achieves high concentrations in phagocytic cells and in fibroblasts. The newer macrolides also have this property but the intracellular penetration of azithromycin in relation to extracellular concentration is particularly notable. As a
Publikováno v:
Journal of Medical Microbiology. 32:93-100
Summary Cell-surface hydrophobicity of Helicobacter (formerly Campylobacter) pylori was tested by aqueous two-phase partitioning and hydrophobic interaction chomato-graphy. The hydrophobicity of H. pylori greatly exceeded that of Campylobacter fetus
Autor:
H. Pruul, P. J. McDonald
Publikováno v:
Journal of Antimicrobial Chemotherapy. 25:91-101
The post-antibiotic effect (PAE) of lomefloxacin against Escherichia coli and Pseudomonas aeruginosa was determined and compared with various other antibiotics. All the quinolones tested, and chloramphenicol and gentamicin, possessed PAE activity. At
Autor:
Peter J. McDonald, H. Pruul
Publikováno v:
Current infectious disease reports. 3(4)
Autor:
H. Pruul, P J McDonald
Publikováno v:
Antimicrobial agents and chemotherapy. 40(8)
Studies of the uptake of beta-lactam antibiotics indicate that they do not accumulate in phagocytic cells. Uptake of beta-lactams is thought to occur through passive diffusion, and this is limited because of their acidic nature. Many studies of antib
Autor:
H. Pruul, Peter J. McDonald
Publikováno v:
The Journal of antimicrobial chemotherapy. 30(4)
In this study we investigated the influence of serum ultrafiltrate on the activities of azithromycin, other macrolides and unrelated antibiotics against Escherichia coli. In the presence of serum ultrafiltrate the MIC of azithromycin was decreased by
Autor:
P J, McDonald, H, Pruul
Publikováno v:
Scandinavian journal of infectious diseases. Supplementum. 83
Macrolides achieve much greater in vivo and clinical efficacy than might be expected from standard in vitro testing. There is accumulating evidence to suggest that macrolides act synergistically with the host immune system. In contrast to beta-lactam
Publikováno v:
European Journal of Clinical Microbiology. 5:405-410
After exposure to erythromycin, group A streptococci were tested for susceptibility to the antimicrobial activity of human peripheral blood neutrophils in the absence of the antibiotic. Bacterial susceptibility to phagocytic killing increased after p