Zobrazeno 1 - 10
of 315
pro vyhledávání: '"H, Piersma"'
Autor:
Judith Regina Homberg, Aldert H. Piersma, Cyrille A. M. Krul, Lisa Genzel, Anne Kienhuis, Ellen ter Gast, Monique Wolvekamp
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
There is a long-standing debate about experimental non-human animals and animal-free methods in scientific research. Among the various stakeholders involved in the debate are the scientists. During media broadcasts we, animal researchers and animal-f
Externí odkaz:
https://doaj.org/article/635ca6d6da474113aff1ecac72af5b08
Autor:
Marie P.F. Corradi, Alyanne M. de Haan, Bernard Staumont, Aldert H. Piersma, Liesbet Geris, Raymond H.H. Pieters, Cyrille A.M. Krul, Marc A.T. Teunis
Publikováno v:
Biomaterials and Biosystems, Vol 7, Iss , Pp 100061- (2022)
Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiating event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a st
Externí odkaz:
https://doaj.org/article/aa0f32b77c024ebd9017437a87e31bbf
Autor:
Aldert H. Piersma, Nancy C. Baker, George P. Daston, Burkhard Flick, Michio Fujiwara, Thomas B. Knudsen, Horst Spielmann, Noriyuki Suzuki, Katya Tsaioun, Hajime Kojima
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100074- (2022)
This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide diversity
Externí odkaz:
https://doaj.org/article/0e3fcdf035aa43749c37ad3ba069d7ff
Autor:
Michael A. Garland, Sumitra Sengupta, Lijoy K. Mathew, Lisa Truong, Esther de Jong, Aldert H. Piersma, Jane La Du, Robert L. Tanguay
Publikováno v:
Toxicology Reports, Vol 6, Iss , Pp 529-537 (2019)
We previously used a chemical genetics approach with the larval zebrafish to identify small molecule inhibitors of tissue regeneration. This led to the discovery that glucocorticoids (GC) block early stages of tissue regeneration by the inappropriate
Externí odkaz:
https://doaj.org/article/7c87a8bbf9e045cc8a3764e044060f98
Autor:
Laura M.M. Samrani, Jeroen L.A. Pennings, Nina Hallmark, Rémi Bars, Helen Tinwell, Marc Pallardy, Aldert H. Piersma
Publikováno v:
Reproductive Toxicology. 115:8-16
The zebrafish embryotoxicity test (ZET) is widely used in developmental toxicology. The analysis of gene expression regulation in ZET after chemical exposure provides mechanistic information about the effects of chemicals on morphogenesis in the test
Autor:
Styliani Fragki, Jochem Louisse, Bas Bokkers, Mirjam Luijten, Ad Peijnenburg, Deborah Rijkers, Aldert H. Piersma, Marco J. Zeilmaker
Publikováno v:
Food and Chemical Toxicology, 172
Food and Chemical Toxicology 172 (2023)
Food and Chemical Toxicology 172 (2023)
Per: and polyfluoroalkyl substances (PFASs) have been associated with increased blood lipids in humans. Perfluorooctanoic acid (PFOA) has been also linked with elevated alanine transferase (ALT) serum levels in humans, and in rodents the liver is a m
Autor:
Maarke J.E. Roelofs, A. Roberto Temming, Aldert H. Piersma, Martin van den Berg, Majorie B.M. van Duursen
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 271-283 (2014)
Conazole fungicides are widely used in agriculture despite their suspected endocrine disrupting properties. In this study, the potential (anti-)androgenic effects of ten conazoles were assessed and mutually compared with existing data. Effects of cyp
Externí odkaz:
https://doaj.org/article/cef77bcf879e4228a22242c1696d420f
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 1513-1520 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Organophosphates induced distinctive effects on neural crest cells within the ESTc. • Neural crest gene transcripts were of added value to the original ESTc read-out. • Mechanistic information adds value to
Highlights • Organophosphates induced distinctive effects on neural crest cells within the ESTc. • Neural crest gene transcripts were of added value to the original ESTc read-out. • Mechanistic information adds value to
Autor:
Harm J. Heusinkveld, Aldert H. Piersma, Yvonne C.M. Staal, George P. Daston, Nancy C. Baker, Thomas B. Knudsen
Publikováno v:
Reprod Toxicol
In recent years, the development and implementation of animal-free approaches to chemical and pharmaceutical hazard and risk assessment has taken off. Alternative approaches are being developed starting from the perspective of human biology and physi