Zobrazeno 1 - 10
of 334
pro vyhledávání: '"H, Pasternak"'
Autor:
Chloe A. Stewart, Derek G. V. Mitchell, Penny A. MacDonald, Stephen H. Pasternak, Paul F. Tremblay, Elizabeth C. Finger
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Guilt is a negative emotion elicited by realizing one has caused actual or perceived harm to another person. One of guilt’s primary functions is to signal that one is aware of the harm that was caused and regrets it, an indication that the
Externí odkaz:
https://doaj.org/article/f27f3b49f7e146d5ab10ba71bde3bfed
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31077- (2024)
The overproduction of the toxic peptide amyloid-beta (Aβ) generated from the cleavage of amyloid precursor protein (APP) is proposed to be a critical event in the development of Alzheimer's disease. Evidence suggests that the cleavage of APP occurs
Externí odkaz:
https://doaj.org/article/f45a7b44a2e048a0844864d2608eaa77
Autor:
A. D. Roseborough, S. J. Myers, R. Khazaee, Y. Zhu, L. Zhao, E. Iorio, F. M. Elahi, S. H. Pasternak, S. N. Whitehead
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Chronic microglia activation post-stroke is associated with worse neurological and cognitive outcomes. However, measurement of microglia activation in vivo is currently limited. Plasma derived extracellular vesicles (EVs) are cell-specific i
Externí odkaz:
https://doaj.org/article/c1ac8d920a2a4916bc0b64c7b1ea4de5
Publikováno v:
Results in Engineering, Vol 18, Iss , Pp 101042- (2023)
Fixed beam-to-column joints in steel portal frames with bolted connections typically present stiffeners to ensure proper load bearing resistance and stiffness to the joint. Executing the same stiffeners with a reduced height (e.g. partial height web
Externí odkaz:
https://doaj.org/article/de3b6d6d61dd478d87436677c4155fe8
Autor:
Allison A. Dilliott, Abdalla Abdelhady, Kelly M. Sunderland, Sali M. K. Farhan, Agessandro Abrahao, Malcolm A. Binns, Sandra E. Black, Michael Borrie, Leanne K. Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Sanjeev Kumar, Donna Kwan, Anthony E. Lang, Jennifer Mandzia, Mario Masellis, Adam D. McIntyre, Stephen H. Pasternak, Bruce G. Pollock, Tarek K. Rajji, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christine Sato, Dallas Seitz, Christen Shoesmith, Thomas D. L. Steeves, Richard H. Swartz, Brian Tan, David F. Tang-Wai, Maria C. Tartaglia, John Turnbull, Lorne Zinman, ONDRI Investigators, Robert A. Hegele
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Genetic factors contribute to neurodegenerative diseases, with high heritability estimates across diagnoses; however, a large portion of the genetic influence remains poorly understood. Many previous studies have attempted to fill the gaps b
Externí odkaz:
https://doaj.org/article/c14898e55b0f4ab5b45663002d305766
Autor:
Allison A. Dilliott, Kristina K. Zhang, Jian Wang, Agessandro Abrahao, Malcolm A. Binns, Sandra E. Black, Michael Borrie, Dar Dowlatshahi, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Sanjeev Kumar, Anthony E. Lang, Jennifer Mandzia, Mario Masellis, Stephen H. Pasternak, Bruce G. Pollock, Tarek K. Rajji, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christine Sato, Dallas Seitz, Christen Shoesmith, Thomas D. L. Steeves, Richard H. Swartz, Brian Tan, David F. Tang‐Wai, Maria C. Tartaglia, John Turnbull, Lorne Zinman, ONDRI Investigators, Robert A. Hegele
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Background Although genetic factors are known to contribute to neurodegenerative disease susceptibility, there remains a large amount of heritability unaccounted for across the diagnoses. Copy number variants (CNVs) contribute to these pheno
Externí odkaz:
https://doaj.org/article/649dad53d67b47c99ebb458bbdb9833e
Autor:
Rachel E. Lackie, Jose Marques-Lopes, Valeriy G. Ostapchenko, Sarah Good, Wing-Yiu Choy, Patricija van Oosten-Hawle, Stephen H. Pasternak, Vania F. Prado, Marco A. M. Prado
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Molecular chaperones and co-chaperones, which are part of the protein quality control machinery, have been shown to regulate distinct aspects of Alzheimer’s Disease (AD) pathology in multiple ways. Notably, the co-chaperone STI1, which pre
Externí odkaz:
https://doaj.org/article/9ee481f80095427e8c20de5968f11484
Autor:
C. R. A. Silveira, J. MacKinley, K. Coleman, Z. Li, E. Finger, R. Bartha, S. A. Morrow, J. Wells, M. Borrie, R. G. Tirona, C. A. Rupar, G. Zou, R. A. Hegele, D. Mahuran, P. MacDonald, M. E. Jenkins, M. Jog, S. H. Pasternak
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Currently there are no disease-modifying treatments for Parkinson’s disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the leading genetic risk f
Externí odkaz:
https://doaj.org/article/39756e13e96e452183057954edee2fa5
Autor:
Austyn D. Roseborough, Kristopher D. Langdon, Robert Hammond, Lauren E. Cipriano, Stephen H. Pasternak, Shawn N. Whitehead, Ali R. Khan
Publikováno v:
NeuroImage: Clinical, Vol 27, Iss , Pp 102340- (2020)
White matter hyperintensities (WMH) occur in normal aging and across diagnostic categories of neurodegeneration. Ultra-high field imaging (UHF) MRI machines offer the potential to improve our understanding of WMH. Post-mortem imaging using UHF magnet
Externí odkaz:
https://doaj.org/article/d1789dfb9d034aca8d2a4831f566c007
Publikováno v:
Pediatrics. 151
Ensuring the confidentiality and protection of health information is the standard of care for adolescents. In 2023 and beyond, the protection of personal health information is more critical than ever. The 21st Century Cures Act Office of the National
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0bddb37556d77c7812ceba43eb66f2
https://doi.org/10.1542/peds.2022-057267k
https://doi.org/10.1542/peds.2022-057267k