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Akademický článek

Using random forest machine learning on data from a large, representative cohort of the general population improves clinical spirometry references

Autor: Kris Kristensen, Pernille H. Olesen, Anna K. Roerbaek, Louise Nielsen, Helle K. Hansen, Simon L. Cichosz, Morten H. Jensen, Ole Hejlesen

Publikováno v: The Clinical Respiratory Journal, Vol 17, Iss 8, Pp 819-828 (2023)

Abstract Introduction Spirometry is associated with several diagnostic difficulties, and as a result, misdiagnosis of chronic obstructive pulmonary disease (COPD) occurs. This study aims to investigate how random forest (RF) can be used to improve th

Externí odkaz: https://doaj.org/article/73c3ef2508f64b418b925a41d357c9fb

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Akademický článek

ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese

Autor: Signe Justesen, Katrine Bilde, Rasmus H. Olesen, Lars H. Pedersen, Erik Ernst, Agnete Larsen

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Obesity has become a global health challenge also affecting reproductive health. In pregnant women, obesity increases the risk of complications such as preterm birth, macrosomia, gestational diabetes, and preeclampsia. Moreover, obesity is a

Externí odkaz: https://doaj.org/article/bb36f5ab6eb14649852be3215d4f5b34

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Akademický článek

Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

Autor: Kristoffer Hendel, Anders C. N. Hansen, Liora Bik, Charlotte Bagger, Martijn B. A. van Doorn, Christian Janfelt, Uffe H. Olesen, Merete Haedersdal, Catharina M. Lerche

Publikováno v: Drug Delivery, Vol 28, Iss 1, Pp 1141-1149 (2021)

Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding l

Externí odkaz: https://doaj.org/article/bcac1147ed034e49920098876ec7e342

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Akademický článek

Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

Autor: Kristoffer K. Hendel, Charlotte Bagger, Uffe H. Olesen, Christian Janfelt, Steen H. Hansen, Merete Haedersdal, Catharina M. Lerche

Publikováno v: Drug Delivery, Vol 26, Iss 1, Pp 244-251 (2019)

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of

Externí odkaz: https://doaj.org/article/07e6d4529e5c4f52b5e2657aaca578eb

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Akademický článek

Laser-assisted delivery enhances topical uptake of the anticancer agent cisplatin

Autor: Emily Wenande, Uffe H. Olesen, Malene R. Boesen, Daniel P. Persson, Catharina M. Lerche, Stefan Stürup, Bente Gammelgaard, Søren Husted, R. Rox Anderson, Merete Haedersdal

Publikováno v: Drug Delivery, Vol 25, Iss 1, Pp 1877-1885 (2018)

Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) expos

Externí odkaz: https://doaj.org/article/7620effbbe9246fb84a5630fe01ca4d4

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Akademický článek

Characterization of Carrier Phase-Based Positioning in Real-World Jamming Conditions

Autor: Søren Skaarup Larsen, Anna B. O. Jensen, Daniel H. Olesen

Publikováno v: Remote Sensing, Vol 13, Iss 14, p 2680 (2021)

GNSS signals arriving at receivers at the surface of the Earth are weak and easily susceptible to interference and jamming. In this paper, the impact of jamming on the reference station in carrier phase-based relative baseline solutions is examined.

Externí odkaz: https://doaj.org/article/619692ec38ad40deb45af8fd172bb97b

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Akademický článek

Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

Autor: Sanne H. Olesen, Donna J. Ingles, Jin-Yi Zhu, Mathew P. Martin, Stephane Betzi, Gunda I. Georg, Joseph S. Tash, Ernst Schönbrunn

Publikováno v: Molecules, Vol 20, Iss 1, Pp 1643-1660 (2015)

The molecular chaperone Hsp90 is regulated by co-chaperones such as p50Cdc37, which recruits a wide selection of client protein kinases. Targeted disruption of the Hsp90-p50Cdc37 complex by protein–protein interaction (PPI) inhibitors has emerged a

Externí odkaz: https://doaj.org/article/00296e6254394b5caf006653751a6a7c

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Functional characterization of water transport and cellular localization of three aquaporin paralogs in the salmonid intestine.

Autor: Steffen S Madsen, Jesper H Olesen, Konstanze eBedal, Morten Buch Engelund, Yohana V Santamarìa, Christian K Tipsmark

Publikováno v: Frontiers in Physiology, Vol 2 (2011)

Intestinal water absorption is greatly enhanced in salmonids upon acclimation from freshwater (FW) to seawater (SW); however, the molecular mechanism for water transport is unknown. We conducted a pharmacological characterization of water absorption

Externí odkaz: https://doaj.org/article/659ffe42790441c0b5f171dd58138921

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