Zobrazeno 1 - 10
of 1 372
pro vyhledávání: '"H, O'Connor"'
Autor:
Jun Wang, Meng Wang, Ala Moshiri, R. Alan Harris, Muthuswamy Raveendran, Tracy Nguyen, Soohyun Kim, Laura Young, Keqing Wang, Roger Wiseman, David H. O’Connor, Zach Johnson, Melween Martinez, Michael J. Montague, Ken Sayers, Martha Lyke, Eric Vallender, Tim Stout, Yumei Li, Sara M. Thomasy, Jeffrey Rogers, Rui Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequencing on 1845 individuals for 3
Externí odkaz:
https://doaj.org/article/3f3b441ea78049f683562adc440c2848
Autor:
Teressa M. Shaw, Samuel T. Dettle, Andres Mejia, Jennifer M. Hayes, Heather A. Simmons, Puja Basu, Jens H. Kuhn, Mitchell D. Ramuta, Cody J. Warren, Peter B. Jahrling, David H. O’Connor, Liupei Huang, Misbah Zaeem, Jiwon Seo, Igor I. Slukvin, Matthew E. Brown, Adam L. Bailey
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 4, Pp 721-731 (2024)
Genetically diverse simian arteriviruses (simarteriviruses) naturally infect geographically and phylogenetically diverse monkeys, and cross-species transmission and emergence are of considerable concern. Characterization of most simarteriviruses beyo
Externí odkaz:
https://doaj.org/article/1a1dc35e15b7408f96c81ee61028b57e
Publikováno v:
eLife, Vol 12 (2024)
Flexible responses to sensory stimuli based on changing rules are critical for adapting to a dynamic environment. However, it remains unclear how the brain encodes and uses rule information to guide behavior. Here, we made single-unit recordings whil
Externí odkaz:
https://doaj.org/article/fb9cd426e1e644cca5d570618d6ef5f9
Autor:
Eric A. Finkel, Yi-Ting Chang, Rajan Dasgupta, Emily E. Lubin, Duo Xu, Genki Minamisawa, Anna J. Chang, Jeremiah Y. Cohen, Daniel H. O’Connor
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113991- (2024)
Summary: The brain receives constant tactile input, but only a subset guides ongoing behavior. Actions associated with tactile stimuli thus endow them with behavioral relevance. It remains unclear how the relevance of tactile stimuli affects processi
Externí odkaz:
https://doaj.org/article/109320505ac24011be2597f2f048c0b6
Autor:
Nicholas R. Minor, Mitchell D. Ramuta, Miranda R. Stauss, Olivia E. Harwood, Savannah F. Brakefield, Alexandra Alberts, William C. Vuyk, Max J. Bobholz, Jenna R. Rosinski, Sydney Wolf, Madelyn Lund, Madison Mussa, Lucas J. Beversdorf, Matthew T. Aliota, Shelby L. O’Connor, David H. O’Connor
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Innovative methods for evaluating virus risk and spread, independent of test-seeking behavior, are needed to improve routine public health surveillance, outbreak response, and pandemic preparedness. Throughout the COVID-19 pandemic, environm
Externí odkaz:
https://doaj.org/article/166834db2a134e03b934fa3d24be52d2
Autor:
Tulika Singh, Itzayana G. Miller, Sravani Venkatayogi, Helen Webster, Holly J. Heimsath, Josh A. Eudailey, Dawn M. Dudley, Amit Kumar, Riley J. Mangan, Amelia Thein, Matthew T. Aliota, Christina M. Newman, Mariel S. Mohns, Meghan E. Breitbach, Madison Berry, Thomas C. Friedrich, Kevin Wiehe, David H. O'Connor, Sallie R. Permar
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Immunodominant and highly conserved flavivirus envelope proteins can trigger cross-reactive IgG antibodies against related flaviviruses, which shapes subsequent protection or disease severity. This study examined how prior dengue serotype 3
Externí odkaz:
https://doaj.org/article/496d519ecdd14e718fa10a683dc6b9bf
Autor:
Marine Megemont, Lucas S. Tortorelli, Jim McBurney-Lin, Jeremiah Y. Cohen, Daniel H. O’Connor, Hongdian Yang
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102785- (2024)
Summary: An extensive literature describes how pupil size reflects neuromodulatory activity, including the noradrenergic system. Here, we present a protocol for the simultaneous recording of optogenetically identified locus coeruleus (LC) units and p
Externí odkaz:
https://doaj.org/article/2e0cafb1cf014345b022448708cbdde3
Autor:
Michael W Grunst, Hwi Min Gil, Andres G Grandea, Brian J Snow, Raiees Andrabi, Rebecca Nedellec, Iszac Burton, Natasha M Clark, Sanath Kumar Janaka, Nida K Keles, Ryan V Moriarty, Andrea M Weiler, Saverio Capuano, Christine M Fennessey, Thomas C Friedrich, Shelby L O'Connor, David H O'Connor, Aimee T Broman, Brandon F Keele, Jeffrey D Lifson, Lars Hangartner, Dennis R Burton, David T Evans
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011819 (2024)
Fc-mediated antibody effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can contribute to the containment HIV-1 replication but whether such activities are sufficient for protection is unclear. We previously identified an an
Externí odkaz:
https://doaj.org/article/8f8b7d273bab487cb298ce773438920f
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Interactions between tumor cells and the tumor microenvironment are critical for tumor growth, progression, and response to therapy. Effective targeting of oncogenic signaling pathways in tumors requires an understanding of how these therapi
Externí odkaz:
https://doaj.org/article/2f997a933bb946c0bbfe6ea9a394fa92
Autor:
Olivia E Harwood, Lea M Matschke, Ryan V Moriarty, Alexis J Balgeman, Abigail J Weaver, Amy L Ellis-Connell, Andrea M Weiler, Lee C Winchester, Courtney V Fletcher, Thomas C Friedrich, Brandon F Keele, David H O'Connor, Jessica D Lang, Matthew R Reynolds, Shelby L O'Connor
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011676 (2023)
Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-haplomatched cohort of MHC-M3+ SIVmac239+ Mauritian cynomolgus ma
Externí odkaz:
https://doaj.org/article/4923447812844a0a8eb8bb1afde9858e