Zobrazeno 1 - 10
of 558
pro vyhledávání: '"H, Miner"'
Autor:
Kyle N. Goodman, Pongpratch Puapatanakul, Kevin T. Barton, Mai He, Jeffrey H. Miner, Joseph P. Gaut
Publikováno v:
Case Reports in Nephrology, Vol 2024 (2024)
Congenital nephrotic syndrome is an autosomal recessive inherited disorder that manifests as steroid-resistant massive proteinuria in the first three months of life. Defects in the glomerular filtration mechanism are the primary etiology. We present
Externí odkaz:
https://doaj.org/article/0e295dc4153c40d1bc7d22510c009953
Autor:
Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Haojia Wu, Kohei Omachi, Nicolas Ledru, Parker C. Wilson, Andrew J. King, N. Eric Olson, Marvin G. Gunawan, Jay J. Kuo, Jennifer H. Cox, Jeffrey H. Miner, Stephen L. Seliger, Owen M. Woodward, Paul A. Welling, Terry J. Watnick, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD a
Externí odkaz:
https://doaj.org/article/7703e88d9d3a4383b2b0dd9ea8ab76ec
Autor:
Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner, Hironobu Fujiwara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional
Externí odkaz:
https://doaj.org/article/cd420d1bdef94731b034f9f7e801a566
Autor:
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis. However, the ability of metformin to improve n
Externí odkaz:
https://doaj.org/article/d6c03b25c7634eeda9e0874c08df981e
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103891- (2022)
Summary: Alport syndrome, a disease of kidney, ear, and eye, is caused by pathogenic variants in the COL4A3, COL4A4, or COL4A5 genes encoding collagen α3α4α5(IV) of basement membranes. Collagen IV chains that are truncated due to nonsense variants
Externí odkaz:
https://doaj.org/article/a879f32f26914813b12c4caa57e43e93
Autor:
Grace H. Miner, PhD, Alan E. Renton, PhD, Ella Taubenfeld, BS, Rami O. Tadros, MD, Edoardo Marcora, PhD, Robert A. Lookstein, MD, Peter L. Faries, MD, Michael L. Marin, MD
Publikováno v:
JVS - Vascular Science, Vol 1, Iss , Pp 233-245 (2020)
Objective: The objective of this study was to better understand the pathophysiology and underlying genetic mechanisms behind two abdominal aortic aneurysm (AAA) subtypes using computed tomographic imaging in combination with whole genome sequencing.
Externí odkaz:
https://doaj.org/article/bdb6181ea76f43baafbd2483d29e5eb2
Autor:
Kohei Omachi, Jeffrey H Miner
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270008 (2022)
CRISPR/Cas9-mediated transcriptional activation (CRISPRa) is a powerful tool for investigating complex biological phenomena. Although CRISPRa approaches based on the VP64 transcriptional activator have been widely studied in both cultured cells and i
Externí odkaz:
https://doaj.org/article/401ae68c92e5485080ecbf92d0e8ad57
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Abstract Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4
Externí odkaz:
https://doaj.org/article/dfc7f6f76ecc4c2db8ed01da88b91819
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasa
Externí odkaz:
https://doaj.org/article/11d9a6a3fdaa4ada87b7b914d705dde8
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F505-F510
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88e303f38eb91c99386902d4ca045ab3
https://doi.org/10.1152/ajprenal.00045.2023
https://doi.org/10.1152/ajprenal.00045.2023