Zobrazeno 1 - 10
of 638
pro vyhledávání: '"H, McDermott"'
Autor:
Mark R. Saddler, Josh H. McDermott
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Neurons encode information in the timing of their spikes in addition to their firing rates. Spike timing is particularly precise in the auditory nerve, where action potentials phase lock to sound with sub-millisecond precision, but its behav
Externí odkaz:
https://doaj.org/article/72229ba804d64a7bbf6cd757ce606ddf
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
ObjectiveNational Institute for Clinical Excellence (NICE) guidance for the management of neonatal sepsis recommends a first-line antibiotic regimen containing an aminoglycoside (gentamicin). Aminoglycoside exposure causes sensorineural hearing loss
Externí odkaz:
https://doaj.org/article/097e9fc2f95340adbf29ecdf08e6fc78
Publikováno v:
Clocks & Sleep, Vol 6, Iss 1, Pp 11-23 (2023)
Background: Day-to-day variations in sleep timing have been associated with poorer glycemic control in type 2 diabetes mellitus, although the factors that influence this sleep timing variability are poorly understood. Methods: Daily routines of sleep
Externí odkaz:
https://doaj.org/article/98a4cf3ef1dc4f04866c43e2aa2c6278
Autor:
Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau, Amélie Bonaud, Maria Kalogeraki, Antoine Boutin, Julia P. Lemos, Valeria Bisio, Joyce Koenen, Lea Hanna Doumit Sakr, Amandine Picart, Amélie Coudert, Sylvain Provot, Nicolas Dulphy, Michel Aurrand-Lions, Stéphane J. C. Mancini, Gwendal Lazennec, David H. McDermott, Fabien Guidez, Claudine Blin-Wakkach, Philip M. Murphy, Martine Cohen-Solal, Marion Espéli, Matthieu Rouleau, Karl Balabanian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model. Imbalanced bone ti
Externí odkaz:
https://doaj.org/article/71e743108c284ff4a7d508b10f487735
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002366 (2023)
Models that predict brain responses to stimuli provide one measure of understanding of a sensory system and have many potential applications in science and engineering. Deep artificial neural networks have emerged as the leading such predictive model
Externí odkaz:
https://doaj.org/article/9e46bb4d8a6a4331910c92b7fee89f67
Autor:
David H. McDermott, Daniel Velez, Elena Cho, Edward W. Cowen, John J. DiGiovanna, Diana V. Pastrana, Christopher B. Buck, Katherine R. Calvo, Pamela J. Gardner, Sergio D. Rosenzweig, Pamela Stratton, Melissa A. Merideth, H. Jeffrey Kim, Carmen Brewer, James D. Katz, Douglas B. Kuhns, Harry L. Malech, Dean Follmann, Michael P. Fay, Philip M. Murphy
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
BACKGROUND Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function CXCR4 mutations. Myelokathexis is a kind of neutropenia caused by neutrophil retenti
Externí odkaz:
https://doaj.org/article/98358f563c30456d8a0d14cbd0e6b4b5
Publikováno v:
Clocks & Sleep, Vol 4, Iss 4, Pp 658-674 (2022)
Variability in the timing of daily sleep is increasingly recognized as an important factor in sleep and general physical health. One potential driver of such daily variations in sleep timing is different work and social obligations during the “work
Externí odkaz:
https://doaj.org/article/60c59020244d4874a6d88e39d230aac6
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
The neural and computational mechanisms underpinning pitch perception remain unclear. Here, the authors trained deep neural networks to estimate the fundamental frequency of sounds and found that human pitch perception depends on precise spike timing
Externí odkaz:
https://doaj.org/article/6c723662417143388a6822a7317d5491
Autor:
John H. McDermott, Stuart Wright, Videha Sharma, William G. Newman, Katherine Payne, Paul Wilson
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Several healthcare organizations have developed pre-emptive pharmacogenetic testing programs, where testing is undertaken prior to the prescription of a medicine. This review characterizes the barriers and facilitators which influenced the developmen
Externí odkaz:
https://doaj.org/article/3b1efa8fe9c74ad08f55d7f1691342b9
Autor:
Maria Batool, David Fennell, David Slattery, Eamon Leen, Liam Cormican, Seamus Sreenan, John H McDermott
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-4 (2021)
Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases/million/year. A majority of patients present with steroid hormone excess or abdominal mass effects, and in 15% of patients ACC is discovered incidentally. We pre
Externí odkaz:
https://doaj.org/article/1ba2270e307346fd82f68d823b2e1be9