Zobrazeno 1 - 10
of 95
pro vyhledávání: '"H, Lomeli"'
Autor:
Sixue Liu, Hannah M. Knochelmann, Shirley H. Lomeli, Aayoung Hong, Mary Richardson, Zhentao Yang, Raymond J. Lim, Yan Wang, Camelia Dumitras, Kostyantyn Krysan, Cynthia Timmers, Martin J. Romeo, Carsten Krieg, Elizabeth C. O’Quinn, Joshua D. Horton, Steve M. Dubinett, Chrystal M. Paulos, David M. Neskey, Roger S. Lo
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100411- (2021)
Summary: Neoadjuvant PD-1 blockade may be efficacious in some individuals with high-risk, resectable oral cavity head and neck cancer. To explore correlates of response patterns to neoadjuvant nivolumab treatment and post-surgical recurrences, we ana
Externí odkaz:
https://doaj.org/article/39a1c3a08dca431b9aeaf1eb80b12cdf
Autor:
Hannah M. Knochelmann, Joshua D. Horton, Sixue Liu, Kent Armeson, John M. Kaczmar, Megan M. Wyatt, Mary S. Richardson, Shirley H. Lomeli, Ying Xiong, Evan M. Graboyes, Eric J. Lentsch, Joshua D. Hornig, Judith Skoner, Seth Stalcup, Maria V. Spampinato, Elizabeth Garrett-Mayer, Elizabeth C. O’Quinn, Cynthia D. Timmers, Martin J. Romeo, John M. Wrangle, M. Rita I. Young, Mark P. Rubinstein, Terry A. Day, Roger S. Lo, Chrystal M. Paulos, David M. Neskey
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100426- (2021)
Summary: Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence and poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic head and neck cancer. Ho
Externí odkaz:
https://doaj.org/article/106d0eef51b345229c78936aef78ee40
Autor:
Prashanthi Dharanipragada, Xiao Zhang, Sixue Liu, Shirley H. Lomeli, Aayoung Hong, Yan Wang, Zhentao Yang, Kara Z. Lo, Agustin Vega-Crespo, Antoni Ribas, Stergios J. Moschos, Gatien Moriceau, Roger S. Lo
Publikováno v:
Cancer discovery, vol 13, iss 4
Blocking cancer genomic instability may prevent tumor diversification and escape from therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6995dba92270918b6dcc93f126d19941
https://doi.org/10.1158/2159-8290.cd-22-0787
https://doi.org/10.1158/2159-8290.cd-22-0787
Autor:
King L. Hung, Jens Luebeck, Siavash R. Dehkordi, Caterina I. Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H. Lomeli, Natasha E. Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E. Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G. Henssen, Julie A. Law, William J. Greenleaf, Roger S. Lo, Paul S. Mischel, Vineet Bafna, Howard Y. Chang
Publikováno v:
Nature genetics, vol 54, iss 11
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment and pulsed field gel electrophoresis of agarose-entrapped genomic DNA, previously devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1d24056e03472a95c8b1515921aefc
https://doi.org/10.1038/s41588-022-01190-0
https://doi.org/10.1038/s41588-022-01190-0
Autor:
Sixue Liu, Prashanthi Dharanipragada, Shirley H. Lomeli, Yan Wang, Xiao Zhang, Zhentao Yang, Raymond J. Lim, Camelia Dumitras, Philip O. Scumpia, Steve M. Dubinett, Gatien Moriceau, Douglas B. Johnson, Stergios J. Moschos, Roger S. Lo
Publikováno v:
Nature medicine, vol 29, iss 5
Metastasis and failure of present-day therapies represent the most common causes of mortality in patients with cutaneous melanoma. To identify the underlying genetic and transcriptomic landscapes, in this study we analyzed multi-organ metastases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5318bf99218234a1a5a9d8f3309df644
https://escholarship.org/uc/item/62m629hn
https://escholarship.org/uc/item/62m629hn
Autor:
Roger S. Lo, Marco Piva, James Wohlschlegel, Gatien Moriceau, Shirley H. Lomeli, Weixian Deng, Sixue Liu, Yan Wang, Zhentao Yang
MAPK inhibitor (MAPKi) therapy in melanoma leads to the accumulation of tumor-surface PD-L1/L2, which may evade antitumor immunity and accelerate acquired resistance. Here, we discover that the E3 ligase ITCH binds, ubiquitinates, and downregulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111ec1aacf50fa29991697c1a93f9af9
https://doi.org/10.1158/2159-8290.c.6549595.v1
https://doi.org/10.1158/2159-8290.c.6549595.v1
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding the structure and dynamics of FAs is critical for designing treatments that overcome plasticity-mediated resistance. We developed a melanoma model of dual MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005496410afa192ef817de39cbb29907
https://doi.org/10.1158/2159-8290.c.6549616.v1
https://doi.org/10.1158/2159-8290.c.6549616.v1
Autor:
Roger S. Lo, Gatien Moriceau, Stergios J. Moschos, Antoni Ribas, Agustin Vega-Crespo, Kara Z. Lo, Zhentao Yang, Yan Wang, Aayoung Hong, Shirley H. Lomeli, Sixue Liu, Xiao Zhang, Prashanthi Dharanipragada
Supplementary Figure S1. Associations of CGRs and ecDNAs with ploidy, expression, and enhancers. Supplementary Figure S2. Analysis of chromothripsis, ecDNAs, and CGRs in MAPKi-sensitive/-naïve versus -resistant melanoma. Supplementary Figure S3. Inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6821b8ab7c86a2aba19e8b8987f693c4
https://doi.org/10.1158/2159-8290.22553401
https://doi.org/10.1158/2159-8290.22553401
Autor:
Thomas G. Graeber, Roger S. Lo, Vineet Bafna, Daniel S. Peeper, Asha S. Multani, P. Nagesh Rao, Paul J. Hergenrother, Kim H. Paraiso, T. Niroshi Senaratne, Stephen E. Motika, Amelia Palermo, Johanna ten Hoeve, Kyle Sheu, Salwan Alhani, Nikolas G. Balanis, Rachana Jayaraman, Gabriel Karin, Eli Pazol, Jesus Salazar, William P. Crosson, Trevor Ridgley, Prashanthi Dharanipragada, Oscar Krijgsman, Gatien Moriceau, Mark H. Goodman, Jens Luebeck, Shirley H. Lomeli, Siavash R. Dehkordi, Arthur Huang, Jenna K. Minami, Kai Song
Supplementary Table from Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8c4bd05ca644172e944aa05c3ccc9
https://doi.org/10.1158/2159-8290.22541326
https://doi.org/10.1158/2159-8290.22541326
Autor:
Roger S. Lo, Marco Piva, James Wohlschlegel, Gatien Moriceau, Shirley H. Lomeli, Weixian Deng, Sixue Liu, Yan Wang, Zhentao Yang
Supplementary Figure from Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f145c6714612715eed62b6418e2b997
https://doi.org/10.1158/2159-8290.22541263.v1
https://doi.org/10.1158/2159-8290.22541263.v1