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Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial

Autor: Marius M Hoeper, Hikmet Al-Hiti, Raymond L Benza, Sung-A Chang, Paul A Corris, J Simon R Gibbs, Ekkehard Grünig, Pavel Jansa, James R Klinger, David Langleben, Vallerie V McLaughlin, Gisela M B Meyer, Jaquelina Ota-Arakaki, Andrew J Peacock, Tomás Pulido, Stephan Rosenkranz, Carmine Dario Vizza, Anton Vonk-Noordegraaf, R James White, Mikyung Chang, Frank Kleinjung, Christian Meier, Karen Paraschin, Hossein Ardeschir Ghofrani, Gérald Simonneau, H Olschewski, M Delcroix, M Andrade-Lima, R de Amorim Corrêac, F Figueiredo Campos, J Ota Arakaki, G Meyer, R De Souza, D Langleben, H Al-Hiti, P Jansa, S Mellemkjær, F Bauer, D Montani, G Simonneau, D Drömann, H-A Ghofrani, E Grünig, M Halank, M Held, MM Hoeper, H Klose, N Kneidinger, H Leuchte, C Opitz, S Rosenkranz, H Wilkens, H Wirtz, H Karvounis, G Pitsiou, S Orfanos, M D'Alto, S Ghio, CD Vizza, P Vitulo, T Nakayama, H Maki, S Tatebe, M de los Rios Ibarra, T Pulido, A Van Dijk, A Vonk-Noordegraaf, T Roleder, G Castro, MJ Loureiro, S Robalo-Martins, JA Barberá, M Lázaro, GM Perez-Penate, A Román, C-C Cheng, C-H Hsu, H-H Hsu, E Atahan, N Mogulkoc Bishop, NG Okumus, Z Onen, H-J Chang, S-A Chang, J-S Lee, H-K Kim, JG Coghlan, PA Corris, AC Church, R Condliffe, JSR Gibbs, AJ Peacock, S Wort, R Allen, S Allen, R Awdish, RL Benza, S DeSouza, J Feldman, S Johri, JR Klinger, D Layish, J McConnell, VV McLaughlin, C Migliore, F Rahaghi, F Rischard, I Robbins, L Satterwhite, T Shah, R Sulica, RJ White

Publikováno v: The Lancet Respiratory Medicine, 9(6), 573-584. Elsevier Limited
Hoeper, M M, Al-Hiti, H, Benza, R L, Chang, S-A, Corris, P A, Gibbs, J S R, Grünig, E, Jansa, P, Klinger, J R, Langleben, D, McLaughlin, V V, Meyer, G M B, Ota-Arakaki, J, Peacock, A J, Pulido, T, Rosenkranz, S, Vizza, C D, Vonk-Noordegraaf, A, White, R J, Chang, M, Kleinjung, F, Meier, C, Paraschin, K, Ghofrani, H A, Simonneau, G & The REPLACE investigators 2021, ' Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE) : a multicentre, open-label, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 6, pp. 573-584 . https://doi.org/10.1016/S2213-2600(20)30532-4
REPLACE investigators 2021, ' Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial ', The Lancet Respiratory Medicine, vol. 9, no. 6, pp. 573-584 . https://doi.org/10.1016/S2213-2600(20)30532-4

BACKGROUND: Riociguat and phosphodiesterase-5 inhibitors (PDE5i), approved for the treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different mechanisms. Riociguat might be an alternative option for patients with PAH wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56129be8d7d9bbfecf556d9b7ae7f504
https://research.vumc.nl/en/publications/422b5ce8-53f9-4f2f-8e03-8a80ae3dd2b8

[Current Aspects of Definition and Diagnosis of Pulmonary Hypertension]

Autor: T J, Lange, M, Borst, R, Ewert, M, Halank, H, Klose, H, Leuchte, F J, Meyer, H-J, Seyfarth, D, Skowasch, H, Wilkens, M, Held

Publikováno v: Pneumologie (Stuttgart, Germany). 74(12)

At the 6th World Symposium on Pulmonary Hypertension (WSPH), which took place from February 27 until March 1, 2018 in Nice, scientific progress over the past 5 years in the field of pulmonary hypertension (PH) was presented by 13 working groups. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ab4cb242cd30b901d90f046555475037
https://pubmed.ncbi.nlm.nih.gov/32707587

Prognostische Biomarker bei PAH

Autor: M. Halank, M. Kolditz, H. Leuchte

Publikováno v: Atemwegs- und Lungenkrankheiten. 41:554-560

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f23be3dbeac3c375a01b6385c7704ab
https://doi.org/10.5414/atx02084

[Targeted therapy of pulmonary arterial hypertension: Recommendations of the Cologne Consensus Conference 2016]

Autor: M M, Hoeper, C, Apitz, E, Grünig, M, Halank, R, Ewert, H, Kaemmerer, H-J, Kabitz, C, Kähler, H, Klose, H, Leuchte, S, Ulrich, K M, Olsson, O, Distler, S, Rosenkranz, H A, Ghofrani

Publikováno v: Deutsche medizinische Wochenschrift (1946). 141(S 01)

The 2015 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension are also valid for Germany. The guidelines contain detailed recommendations for the targeted treatment of pulmonary arterial hypertension (PAH). However, the practical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09dc57ccc1a9fb65e9090fb0f2ecb9b7
https://pubmed.ncbi.nlm.nih.gov/27760448