Zobrazeno 1 - 10
of 4 273
pro vyhledávání: '"H, Kaplan"'
Autor:
Nicole Ramos Solis, Anthony Cannon, Tinslee Dilday, Melissa Abt, Adrian L. Oblak, Adam C. Soloff, Mark H. Kaplan, Elizabeth S. Yeh
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). TNBC tumors are not sensitive to endocrine therapy, and standardized TNBC treatment
Externí odkaz:
https://doaj.org/article/3b9dc2bcc945418ea6c7b52e97286e08
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103024- (2024)
Summary: Umbilical cord blood (CB) is a donor source for hematopoietic cell therapies. Understanding what drives hematopoietic stem and progenitor cell function is critical to our understanding of the usage of CB in hematopoietic cell therapies. Here
Externí odkaz:
https://doaj.org/article/5cab2e396aa74324a0eada7b17057205
Autor:
Raisa Queiroz Catunda, Karen Ka-yan Ho, Srushti Patel, Christopher Bryant Roy, Maria Alexiou, Liran Levin, Benjamin J. Ulrich, Mark H. Kaplan, Maria Febbraio
Publikováno v:
International Dental Journal, Vol 73, Iss 6, Pp 862-872 (2023)
Objective: The aim of this research was to investigate the role of the cornified epithelium, the outermost layer of the oral mucosa, engineered to prevent water loss and microorganism invasion, in severe forms of periodontitis (stage III or IV, grade
Externí odkaz:
https://doaj.org/article/d7e2955a9c9f48c0b8f05e1695ff1dad
Autor:
Souren Paul, Mark H. Kaplan, Dinesh Khanna, Preston M. McCourt, Anjan K. Saha, Pei-Suen Tsou, Mahek Anand, Alexander Radecki, Mohamad Mourad, Amr H. Sawalha, David M. Markovitz, Rafael Contreras-Galindo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Fibrosis of the skin plays an important role in scleroderma. Here the authors demonstrate genetic and epigenetic abnormalities at the centromere that affect the replication of the chromosomes, resulting in activation of pathways involved in inflammat
Externí odkaz:
https://doaj.org/article/d5eaf6cdd6504e8d8ebc8070af2ffb48
Autor:
Yongyao Fu, Abigail Pajulas, Jocelyn Wang, Baohua Zhou, Anthony Cannon, Cherry Cheuk Lam Cheung, Jilu Zhang, Huaxin Zhou, Amanda Jo Fisher, David T. Omstead, Sabrina Khan, Lei Han, Jean-Christophe Renauld, Sophie Paczesny, Hongyu Gao, Yunlong Liu, Lei Yang, Robert M. Tighe, Paula Licona-Limón, Richard A. Flavell, Shogo Takatsuka, Daisuke Kitamura, Jie Sun, Basar Bilgicer, Catherine R. Sears, Kai Yang, Mark H. Kaplan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The role of IL-9 in the tumor microenvironment and its effects on macrophages remains unclear. Here, the authors show that IL-9 promotes the expansion of pulmonary macrophages and that targeting the IL-9R/arginase 1 axis restricts tumor growth, thus
Externí odkaz:
https://doaj.org/article/a1f3ef8fb84c42fd82f0039ff02e0d71
Publikováno v:
Hydrology and Earth System Sciences, Vol 26, Pp 2671-2696 (2022)
Intermittent streams represent a substantial part of the total stream network, and their occurrence is expected to increase due to climate change. Thus, it is of high relevance to provide detailed information on the temporal and spatial controls of s
Externí odkaz:
https://doaj.org/article/efb8a9f0ba90430ab23d624d06bf22a5
Autor:
Chiranjeevi Tikka, Lindsay Beasley, Chengxian Xu, Jing Yang, Scott Cooper, Joseph Lechner, Sarah Gutch, Mark H. Kaplan, Maegan Capitano, Kai Yang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Bone marrow Treg cells (BM Tregs) orchestrate stem cell niches crucial for hematopoiesis. Yet little is known about the molecular mechanisms governing BM Treg homeostasis and function. Here we report that the transcription factor BATF maintains homeo
Externí odkaz:
https://doaj.org/article/7fd38ae17eba4226b0de116f3e19bac0
Autor:
Michelle Chu, Huanling Gao, Patricia Esparza, Abigail Pajulas, Jocelyn Wang, Rakshin Kharwadkar, Hongyu Gao, Mark H. Kaplan, Robert S. Tepper
Publikováno v:
Physiological Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Populations that are born and raised at high altitude develop under conditions of chronic developmental hypoxia (CDH), which results in pulmonary adaptations of increased lung volume and diffusion capacity to increase gas exchange. It is not
Externí odkaz:
https://doaj.org/article/a2db0584fdb340c8a0d9dd0167af98ca
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-4 (2022)
Abstract Monitoring the progression of SARS-CoV-2 outbreaks requires accurate estimation of the unobservable fraction of the population infected over time in addition to the observed numbers of COVID-19 cases, as the latter present a distorted view o
Externí odkaz:
https://doaj.org/article/471f6f612629499db8804651274c2312
Autor:
Lei Wang, Bianca Graziano, Nicole Encalada, Jesus Fernandez-Abascal, Daryn H. Kaplan, Laura Bianchi
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105684- (2022)
Summary: Glia and accessory cells regulate the microenvironment around neurons and primary sensory cells. However, the impact of specific glial regulators of ions and solutes on functionally diverse primary cells is poorly understood. Here, we system
Externí odkaz:
https://doaj.org/article/88ce3b83208b402c936c1db4f6eec4a2