Zobrazeno 1 - 10
of 121
pro vyhledávání: '"H, Jhoti"'
Autor:
H. Jhoti
Publikováno v:
Small Molecule — Protein Interactions ISBN: 9783662053164
In the past two decades the promise of structure-based drug design has continued to attract significant interest from the pharmaceutical industry. The initial wave of enthusiasm in the late 1980s resulted in some notable successes, for example, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4d45a2eb519b3ac6e69b5524ad4eac
https://ora.ox.ac.uk/objects/uuid:532d5673-09ee-4da4-bc3e-fd8e1dfe5aef
https://ora.ox.ac.uk/objects/uuid:532d5673-09ee-4da4-bc3e-fd8e1dfe5aef
Autor:
M Bajaj, M. Neu, Richard W. Strange, P.F. Lindley, R Sarra, Robert W. Evans, Richard Charles Garratt, H. Jhoti, Adrial R. Walton, S. Samar Hasnain, Paula R. Kuser, K Patel
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 49:292-304
The molecular structure of an iron-containing 18 kDa fragment of duck ovotransferrin, obtained by proteolysis of the intact protein, has been elucidated by protein crystallographic techniques at 2.3 A resolution. This structure supports a mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c6379620a5811437c47a586eb3a2e9
https://doi.org/10.1107/s0907444992012101
https://doi.org/10.1107/s0907444992012101
Autor:
Richard Charles Garratt, H. Jhoti
Publikováno v:
FEBS Letters. 305:55-61
The primary structure of p97 (melanotransferrin) has been compared with other members of the transferrin superfamily. A molecular structure of p97 has been modelled based on the crystal structure of diferric rabbit serum transferrin. The most signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a08f7b10178e62694204e65082842f6
https://doi.org/10.1016/0014-5793(92)80654-y
https://doi.org/10.1016/0014-5793(92)80654-y
Autor:
H, Jhoti
Publikováno v:
Ernst Schering Foundation symposium proceedings. (3)
Fragment-based drug discovery (FBDD) is established as an alternative approach to high-throughput screening for generating novel small molecule drug candidates. In FBDD, relatively small libraries of low molecular weight compounds (or fragments) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f520078ccb2e97b6d5c102f089d9f8e9
https://pubmed.ncbi.nlm.nih.gov/18510103
https://pubmed.ncbi.nlm.nih.gov/18510103
Publikováno v:
Acta Crystallographica Section B Structural Science. 46:763-771
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba432d22fd8b2ed5e2a4774665baab7
https://doi.org/10.1107/s0108768190006450
https://doi.org/10.1107/s0108768190006450
Autor:
O'Brien, P.A. Williams, G. Chessari, M.G. Carr, S. Hiscock, P. Pathuri, Joseph E. Coyle, M. Vinkovic, T. Sambrook, C. Richardson, Anne Cleasby, J.R. Yon, M. Congreve, S. Saalau-Bethell, H. Jhoti, V. Lock, A.J. Woodhead, Christopher William Murray, B. Graham, V Berdini, Sharna J. Rich
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 71:s38-s38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12042e1cee002767ecb265983acc5045
https://doi.org/10.1107/s2053273315099398
https://doi.org/10.1107/s2053273315099398
Autor:
H, Jhoti
Publikováno v:
Ernst Schering Research Foundation workshop. (42)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba08b435d442a56dbe040ff1c8b877d7
https://pubmed.ncbi.nlm.nih.gov/12664535
https://pubmed.ncbi.nlm.nih.gov/12664535
Autor:
R, Dajani, A, Cleasby, M, Neu, A J, Wonacott, H, Jhoti, A M, Hood, S, Modi, A, Hersey, J, Taskinen, R M, Cooke, G R, Manchee, M W, Coughtrie
Publikováno v:
The Journal of biological chemistry. 274(53)
Humans are one of the few species that produce large amounts of catecholamine sulfates, and they have evolved a specific sulfotransferase, SULT1A3 (M-PST), to catalyze the formation of these conjugates. An orthologous protein has yet to be found in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db2be025503b610e297fbb87f2ec96d6
https://pubmed.ncbi.nlm.nih.gov/10608851
https://pubmed.ncbi.nlm.nih.gov/10608851
Publikováno v:
Biochemical Society transactions. 25(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54628d65eae76e7f9eec3bf7df972e8
https://pubmed.ncbi.nlm.nih.gov/9388587
https://pubmed.ncbi.nlm.nih.gov/9388587
Autor:
H. Jhoti, J.R. Yon, A.J. Woodhead, M.G. Carr, C. Richardson, Neil T. Thompson, P. Pathuri, R. McMenamin, Joseph E. Coyle, S. Saalau-Bethell, M. Verdonk, Sharna J. Rich, Christopher William Murray, C.C.F. Hamlett, David C. Rees, B. Graham, P.A. Williams, G. Chessari, S. Hiscock, M. Vinkovic, M. Frederickson, M. Reader, F.P. Holding
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 68:s27-s27
NS3/4a enzyme via structure-based drug design Puja Pathuri, Susanne M. Saalau-Bethell, Andrew J. Woodhead, Maria G. Carr, Gianni Chessari, Joseph Coyle, a Martyn Frederickson, Brent Graham, Chris Hamlett, Steven D. Hiscock, Finn P. Holding, Harren Jh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd7909058a44075d77af7fa1e52dd3f
https://doi.org/10.1107/s0108767312099473
https://doi.org/10.1107/s0108767312099473