Zobrazeno 1 - 10
of 114
pro vyhledávání: '"H, Jarosz"'
Autor:
Heledd H Jarosz-Griffiths, Lindsey Gillgrass, Laura R Caley, Giulia Spoletini, Ian J Clifton, Christine Etherington, Sinisa Savic, Michael F McDermott, Daniel Peckham
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0304555 (2024)
Inflammation is a key driver in the pathogenesis of cystic fibrosis (CF). We assessed the effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on downregulating systemic and immune cell-derived inflammatory cytokines. We also monitored the
Externí odkaz:
https://doaj.org/article/caa59c7e9d2246b8a30553c4cecf4594
Autor:
Mark L. Dallas, Moza M. Al-Owais, Nishani T. Hettiarachchi, Matthew Scott Vandiver, Heledd H. Jarosz-Griffiths, Jason L. Scragg, John P. Boyle, Derek Steele, Chris Peers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Hydrogen sulfide (H2S) is gaining interest as a mammalian signalling molecule with wide ranging effects. S-sulfhydration is one mechanism that is emerging as a key post translational modification through which H2S acts. Ion channels and neur
Externí odkaz:
https://doaj.org/article/13083c3f35814e67b0e44923d6daf923
Autor:
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Michael F. McDermott
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue. These diseases are characterised by a progressive neuronal loss in the brain or p
Externí odkaz:
https://doaj.org/article/2c93e60cfc644780a68c2a7a589e88bd
Autor:
Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato
Externí odkaz:
https://doaj.org/article/e72e404e8886401f9e9b651bbc12b5a4
Autor:
Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott
Publikováno v:
eLife, Vol 8 (2019)
Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium c
Externí odkaz:
https://doaj.org/article/4da6ca1aca8646a0aba1a7636105b237
Autor:
Samuel Lara-Reyna, Thomas Scambler, Jonathan Holbrook, Chi Wong, Heledd H. Jarosz-Griffiths, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F. McDermott
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cystic Fibrosis (CF) is a recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins a
Externí odkaz:
https://doaj.org/article/f225fc1ab25740098c9d3164db1b5f47
Autor:
H. Jarosz-Griffiths, L. Gillgrass, G. Spoletini, I. Clifton, C. Etherington, S. Savic, M.F. McDermott, D. Peckham
Publikováno v:
Journal of Cystic Fibrosis. 21:S69-S70
Autor:
Moza M. Al-Owais, John P. Boyle, Jason L. Scragg, Mark L. Dallas, Heledd H. Jarosz-Griffiths, Nishani T. Hettiarachchi, Chris Peers, Derek S. Steele, Matthew Scott Vandiver
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Hydrogen sulfide (H2S) is gaining interest as a mammalian signalling molecule with wide ranging effects. S-sulfhydration is one mechanism that is emerging as a key post translational modification through which H2S acts. Ion channels and neuronal rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabfa65c03c02b87e1aa15b5d088b1e2
https://centaur.reading.ac.uk/97442/1/s41598-021-87646-5.pdf
https://centaur.reading.ac.uk/97442/1/s41598-021-87646-5.pdf
Autor:
Michael F. McDermott, J. Holbrook, Samuel Lara-Reyna, Daniel Peckham, Heledd H. Jarosz-Griffiths
Publikováno v:
Cellular and Molecular Life Sciences
Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in Caucasians, caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF is a multi-organ disease that involves the lungs, pancre
Autor:
Daniel Peckham, Paul Whitaker, Anil Mehta, Sinisa Savic, Michael F. McDermott, T. Scambler, J. Holbrook, Christine Etherington, Ian Clifton, Heledd H. Jarosz-Griffiths, Samuel Lara-Reyna, Giulia Spoletini, C. Wong, Fabio Martinon
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556
Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56c3b19820b0ec649de1acb486b5ee6
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf