Zobrazeno 1 - 10
of 250
pro vyhledávání: '"H, Janssens"'
Autor:
Steven Henikoff, Jorja G. Henikoff, Kami Ahmad, Ronald M. Paranal, Derek H. Janssens, Zachary R. Russell, Frank Szulzewsky, Sita Kugel, Eric C. Holland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract For more than a century, formalin-fixed paraffin-embedded (FFPE) sample preparation has been the preferred method for long-term preservation of biological material. However, the use of FFPE samples for epigenomic studies has been difficult b
Externí odkaz:
https://doaj.org/article/b26b249b67ba49b091b4359f80998da8
Autor:
Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011101 (2023)
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR which uses the
Externí odkaz:
https://doaj.org/article/5cef2c8dd6f648b190d059c1fefe11f9
Autor:
Derek H. Janssens, Dominik J. Otto, Michael P. Meers, Manu Setty, Kami Ahmad, Steven Henikoff
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Cleavage Under Targets and Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and single cells. We describe a modified CUT&Tag protocol using a mixture of an antibod
Externí odkaz:
https://doaj.org/article/2363434c279348e18326a59aafb527f7
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Publikováno v:
eLife, Vol 11 (2022)
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that en
Externí odkaz:
https://doaj.org/article/04134ed54862435e8033d1ac577697c2
Autor:
Derek H. Janssens, Steven J. Wu, Jay F. Sarthy, Michael P. Meers, Carrie H. Myers, James M. Olson, Kami Ahmad, Steven Henikoff
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-14 (2018)
Abstract Background Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introdu
Externí odkaz:
https://doaj.org/article/c7b93f6a290149ae84ea89579b7bf8dc
Autor:
Noemi Rives-Quinto, Hideyuki Komori, Cyrina M Ostgaard, Derek H Janssens, Shu Kondo, Qi Dai, Adrian W Moore, Cheng-Yu Lee
Publikováno v:
eLife, Vol 9 (2020)
Stem cells that indirectly generate differentiated cells through intermediate progenitors drives vertebrate brain evolution. Due to a lack of lineage information, how stem cell functionality, including the competency to generate intermediate progenit
Externí odkaz:
https://doaj.org/article/11637e730c8b4f4db50a0f95566ac828
Publikováno v:
Nature Biotechnology. 41:708-716
Chromatin profiling at locus resolution uncovers gene regulatory features that define cell types and developmental trajectories, but it remains challenging to map and compare different chromatin-associated proteins in the same sample. Here we describ
Autor:
Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman, Patrick J Paddison, Christina M Lockwood, Nicholas A Vitanza, James M Olson, Kami Ahmad, Steven Henikoff
Publikováno v:
eLife, Vol 9 (2020)
Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown ho
Externí odkaz:
https://doaj.org/article/e7dfecb6026a4b9d88e0f6a2bde980c7
Autor:
Femmy C. Stempels, Muwei Jiang, Harry M. Warner, Magda-Lena Moser, Maaike H. Janssens, Sjors Maassen, Iris H. Nelen, Rinse de Boer, William F. Jiemy, David Knight, Julian Selley, Ronan O’Cualain, Maksim V. Baranov, Thomas C.Q. Burgers, Roberto Sansevrino, Dragomir Milovanovic, Peter Heeringa, Matthew C. Jones, Rifka Vlijm, Martin ter Beest, Geert van den Bogaart
Publikováno v:
Journal of Cell Biology, 222
Journal of Cell Biology, 222, 7
The journal of cell biology 222(7), e202205130 (2023). doi:10.1083/jcb.202205130
Journal of Cell Biology, 222, 7
The journal of cell biology 222(7), e202205130 (2023). doi:10.1083/jcb.202205130
Contains fulltext : 292891.pdf (Publisher’s version ) (Open Access) Endosomal Sorting Complex Required for Transport (ESCRT) proteins can be transiently recruited to the plasma membrane for membrane repair and formation of extracellular vesicles. H
Autor:
H. Tiddens, Q. Lv, E.-R. Andrinopoulou, M.W.H. Pijnenburg, H. Janssens, P. Ciet, W.V.D. Bosch
Publikováno v:
A69. AN IMAGE'S WORTH: STUDIES IN LUNG IMAGING.