Zobrazeno 1 - 10
of 405
pro vyhledávání: '"H, Hiemstra"'
Autor:
Ida H. Hiemstra, Kim Santegoets, Maarten Janmaat, Wessel Ten Hagen, Rosanna Sanchez, Lauren Brady, Sieto Bosgra, Marije Overdijk, Jenny Chen, Katrine Fladeland Iversen, Torben Plesner, Esther Breij
Publikováno v:
HemaSphere, Vol 7, p e008261b (2023)
Externí odkaz:
https://doaj.org/article/4f633667bf9e4dc6b0f47f3a8fb66a88
Autor:
Ida H. Hiemstra, Kim C.M. Santegoets, Maarten L. Janmaat, Bart E.C.G. De Goeij, Wessel Ten Hagen, Sanne van Dooremalen, Peter Boross, Jeroen van den Brakel, Sieto Bosgra, Grietje Andringa, Berris van Kessel-Welmers, Dennis Verzijl, Richard G. Hibbert, Kristine A. Frerichs, Tuna Mutis, Niels W.C.J. van de Donk, Tahamtan Ahmadi, David Satijn, A. Kate Sasser, Esther C.W. Breij
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104663- (2023)
Summary: Background: HexaBody®-CD38 (GEN3014) is a hexamerization-enhanced human IgG1 that binds CD38 with high affinity. The E430G mutation in its Fc domain facilitates the natural process of antibody hexamer formation upon binding to the cell surf
Externí odkaz:
https://doaj.org/article/f33bd39a5fdd41bc885381f56bdbe832
Autor:
Hilma J. van der Horst, A. Vera de Jonge, Ida H. Hiemstra, Anne T. Gelderloos, Daniella R. A. I. Berry, Nathalie J. Hijmering, Hendrik F. van Essen, Daphne de Jong, Martine E. D. Chamuleau, Sonja Zweegman, Esther C. W. Breij, Margaretha G. M. Roemer, Tuna Mutis
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 2, Pp 1-8 (2021)
Abstract Epcoritamab (DuoBody-CD3xCD20, GEN3013) is a novel bispecific IgG1 antibody redirecting T-cells toward CD20+ tumor cells. Here, we assessed the preclinical efficacy of epcoritamab against primary tumor cells present in the lymph node biopsie
Externí odkaz:
https://doaj.org/article/1763543d37b64f68b1819cf9d59358d5
Autor:
I. H. Hiemstra, K. Santegoets, M. L. Janmaat, W. Ten Hagen, S. Van Dooremalen, B. E. De Goeij, S. Bosgra, A. K. Sasser, E. C. Breij
Publikováno v:
HemaSphere, Vol 6, Pp 747-748 (2022)
Externí odkaz:
https://doaj.org/article/d69f2def5f724111a7c6ae84fe5a1720
Autor:
Cathelijn E.M. Aarts, Ida H. Hiemstra, Eelke P. Béguin, Arjan J. Hoogendijk, Souhailla Bouchmal, Michel van Houdt, Anton T.J. Tool, Erik Mul, Machiel H. Jansen, Hans Janssen, Floris P.J. van Alphen, Jan-Paul de Boer, Charlotte L. Zuur, Alexander B. Meijer, Timo K. van den Berg, Taco W. Kuijpers
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3562-3574 (2019)
Abstract: Myeloid-derived suppressor cells (MDSCs) have the capacity to suppress T-cell–mediated immune responses and impact the clinical outcome of cancer, infections, and transplantation settings. Although MDSCs were initially described as bone m
Externí odkaz:
https://doaj.org/article/b15945dc1e8e473fb56edb73bec00b22
Autor:
Cathelijn E. M. Aarts, Ida H. Hiemstra, Charita Furumaya, Robin van Bruggen, Taco W. Kuijpers
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Human neutrophils exert a well-known role as efficient effector cells to kill pathogenic micro-organisms. Apart from their role in innate immunity, neutrophils also have the capacity to suppress T cell-mediated immune responses as so-called granulocy
Externí odkaz:
https://doaj.org/article/8a4166b4ca5a4aa787d2380a723a16ca
Autor:
Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Background: DuoBody®-CD3xCD20 (GEN3013) is a full-length human IgG1 bispecific antibody (bsAb) recognizing CD3 and CD20, generated by controlled Fab-arm exchange. Its Fc domain was silenced by introduction of mutations L234F L235E D265A. Methods: T-
Externí odkaz:
https://doaj.org/article/8eed60dbcc62461eb9d7224a1bb469dc
Autor:
Luigi Grassi, Farzin Pourfarzad, Sebastian Ullrich, Angelika Merkel, Felipe Were, Enrique Carrillo-de-Santa-Pau, Guoqiang Yi, Ida H. Hiemstra, Anton T.J. Tool, Erik Mul, Juliane Perner, Eva Janssen-Megens, Kim Berentsen, Hinri Kerstens, Ehsan Habibi, Marta Gut, Marie Laure Yaspo, Matthias Linser, Ernesto Lowy, Avik Datta, Laura Clarke, Paul Flicek, Martin Vingron, Dirk Roos, Timo K. van den Berg, Simon Heath, Daniel Rico, Mattia Frontini, Myrto Kostadima, Ivo Gut, Alfonso Valencia, Willem H. Ouwehand, Hendrik G. Stunnenberg, Joost H.A. Martens, Taco W. Kuijpers
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2784-2794 (2018)
Summary: Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional f
Externí odkaz:
https://doaj.org/article/dc462ba47f53441fbc56441e3b97245e
Autor:
Tommy Li, Ida H. Hiemstra, Christopher Chiu, Roberto S. Oliveri, Brian Elliott, Dena DeMarco, Theodora Salcedo, Frederikke Lihme Egerod, Kate Sasser, Tahamtan Ahmadi, Manish Gupta
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:1108-1119
Epcoritamab is a CD3xCD20 bispecific antibody (bsAb) that induces T-cell-mediated cytotoxicity against CD20-positive B cells. Target engagement and crosslinking of CD3 and CD20 (trimer formation) leads to activation and expansion of T cells and killi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5151e781ab00ccc5120d8c6f950d1fa4
https://doi.org/10.1002/cpt.2729
https://doi.org/10.1002/cpt.2729
Autor:
Arie J. Hoogendijk, Farzin Pourfarzad, Cathelijn E.M. Aarts, Anton T.J. Tool, Ida H. Hiemstra, Luigi Grassi, Mattia Frontini, Alexander B. Meijer, Maartje van den Biggelaar, Taco W. Kuijpers
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2505-2519.e4 (2019)
Summary: Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bo
Externí odkaz:
https://doaj.org/article/468e8cb9603e435dbc1cebda5c7f95a3