Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Autor: Samira Salihovic, Niklas Nyström, Charlotte Bache-Wiig Mathisen, Robert Kruse, Christine Olbjørn, Svend Andersen, Alexandra J. Noble, Maria Dorn-Rasmussen, Igor Bazov, Gøri Perminow, Randi Opheim, Trond Espen Detlie, Gert Huppertz-Hauss, Charlotte R. H. Hedin, Marie Carlson, Lena Öhman, Maria K. Magnusson, Åsa V. Keita, Johan D. Söderholm, Mauro D’Amato, Matej Orešič, Vibeke Wewer, Jack Satsangi, Carl Mårten Lindqvist, Johan Burisch, Holm H. Uhlig, Dirk Repsilber, Tuulia Hyötyläinen, Marte Lie Høivik, Jonas Halfvarson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naï

Externí odkaz: https://doaj.org/article/8a477108fc6e4a34a2cccb17d607374e

DOP14 Identification and validation of a lipidomic signature as a novel diagnostic biomarker of paediatric Inflammatory Bowel Disease

Autor: S Salihovic, N Nyström, C Bache-Wiig Mathisen, S Andersen, C Olbjørn, G Perminow, R Opheim, T E Detlie, G Huppertz-Hauss, I Bazov, R Kruse, C M Lindqvist, C R H Hedin, M Carlson, L Öhman, M Magnusson, Å V Keita, J D Söderholm, M D’Amato, M Orešič, D Repsilber, T Hyötyläinen, M L Hoivik, J Halfvarson

Publikováno v: Journal of Crohn's and Colitis. 17:i76-i77

Background Improved diagnostic biomarkers are an unmet clinical need for paediatric inflammatory bowel disease (IBD). We therefore aimed to identify a diagnostic lipidomic signature of IBD in blood. Methods We performed a non-targeted liquid chromato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccf2ed0b39be818c0c52ba50150854fe
https://doi.org/10.1093/ecco-jcc/jjac190.0054

Ustekinumab treatment in ulcerative colitis: Real-world data from the Swedish inflammatory bowel disease quality register

Autor: Joel, Thunberg, Olle, Björkqvist, Charlotte R H, Hedin, Anders, Forss, Charlotte, Söderman, Daniel, Bergemalm, Ola, Olén, Henrik, Hjortswang, Hans, Strid, Jonas F, Ludvigsson, Carl, Eriksson, Jonas, Halfvarson

Publikováno v: United European gastroenterology journal. 10(7)

Background Real-world data on clinical outcomes of ustekinumab in ulcerative colitis are lacking. Objective To assess short- and long-term clinical outcomes of ustekinumab in ulcerative colitis. Methods Adult ulcerative colitis patients without previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d446211f4867d563ca524b0068aaeb70
https://pubmed.ncbi.nlm.nih.gov/35841129

Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

Autor: Lars E. Borm, Alejandro Mossi Albiach, Camiel C. A. Mannens, Jokubas Janusauskas, Ceren Özgün, David Fernández-García, Rebecca Hodge, Francisca Castillo, Charlotte R. H. Hedin, Eduardo J. Villablanca, Per Uhlén, Ed S. Lein, Simone Codeluppi, Sten Linnarsson

Publikováno v: Nature biotechnology.

Methods to spatially profile the transcriptome are dominated by a trade-off between resolution and throughput. Here we develop a method named Enhanced ELectric Fluorescence in situ Hybridization (EEL FISH) that can rapidly process large tissue sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe1f492a6b17dc33281ae02d1e125b0
https://pubmed.ncbi.nlm.nih.gov/36329278

Results of the Seventh Scientific Workshop of ECCO:Precision medicine in IBD- prediction and prevention of inflammatory bowel disease

Autor: Charlotte R H Hedin, Bram Verstockt, Marla Dubinsky, Tine Jess, Iago Rodríguez-Lago, Joana Torres, Claudio Fiocchi, Michael Scharl, Kenneth Croitoru, Jean-Frederic Colombel, Jonas Halfvarson

Publikováno v: Torres, J, Halfvarson, J, Rodríguez-Lago, I, Hedin, C R H, Jess, T, Dubinsky, M, Croitoru, K, Colombel, J-F & Scientific Workshop Steering Committee 2021, ' Results of the Seventh Scientific Workshop of ECCO : Precision medicine in IBD-prediction and prevention of inflammatory bowel disease ', Journal of Crohn's & colitis, vol. 15, no. 9, pp. 1443-1454 . https://doi.org/10.1093/ecco-jcc/jjab048

Inflammatory bowel disease [IBD] is a complex chronic disorder with no clear aetiology and no known cure. Despite recent advances in overall disease management and improved therapeutics, patients with IBD still experience a substantial burden. Furthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa48a6e40f17238fd468f30c2ed733e
https://vbn.aau.dk/da/publications/4524a69d-7a5d-42a8-8664-9b3fcd67a239